miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways: e0131823

Linker for Activation of T cells (LAT) is an adapter protein that is essential for T cell function. Knock-in mice with a LAT mutation impairing calcium flux develop a fatal CD4+ lymphoproliferative disease. miR-155 is a microRNA that is correlated with hyperproliferation in a number of cancers inclu...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6)
Hauptverfasser:	Rouquette-Jazdanian, Alexandre K, Kortum, Robert L, Li, Wenmei, Merrill, Robert K, Nguyen, Phan H, Samelson, Lawrence E, Sommers, Connie L
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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