$Thrombin induced by the extrinsic pathway and PAR-1 regulated inflammation at the site of fracture repair$

Thrombin induced by the extrinsic pathway and PAR-1 regulated inflammation at the site of fracture repair

Abstract Thrombin (coagulation factor IIa) is a serine protease encoded by the F2 gene. Pro-thrombin (coagulation factor II) is cut to generate thrombin in the coagulation cascade that results in a reduction of blood loss. Procoagulant states that lead to activation of thrombin are common in bone fr...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2016-02, Vol.83, p.23-34
Hauptverfasser:	Sato, Nobutaka, Ichikawa, Jiro, Wako, Masanori, Ohba, Tetsuro, Saito, Masanori, Sato, Hironao, Koyama, Kensuke, Hagino, Tetsuo, Schoenecker, Jonathan G, Ando, Takashi, Haro, Hirotaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Movement Chemokine CCL2 - metabolism Disease Models, Animal Fracture Healing Fracture model Humans Inflammation - metabolism Inflammation - pathology Interleukin-6 - metabolism Male MAP Kinase Signaling System MCP-1 Mice Mice, Inbred C57BL Migration Models, Biological Orthopedics Osteoblasts - metabolism Osteoblasts - pathology PAR-1 Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism RAW 264.7 Cells Receptor, PAR-1 - metabolism Thrombin Thrombin - metabolism Thrombin - pharmacology Thromboplastin - metabolism
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