The impact of high fructose on cardiovascular system: Role of α-lipoic acid
The aim of this study was to evaluate the role of α-lipoic acid (α-LA) on oxidative damage and inflammation that occur in endothelium of aorta and heart while constant consumption of high-fructose corn syrup (HFCS). The rats were randomly divided into three groups with each group containing eight ra...
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| Veröffentlicht in: | Human & experimental toxicology 2016-02, Vol.35 (2), p.194-204 |
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| creator | Saygin, M Asci, H Cankara, FN Bayram, D Yesilot, S Candan, IA Alp, HH |
| description | The aim of this study was to evaluate the role of α-lipoic acid (α-LA) on oxidative damage and inflammation that occur in endothelium of aorta and heart while constant consumption of high-fructose corn syrup (HFCS). The rats were randomly divided into three groups with each group containing eight rats. The groups include HFCS, HFCS + α-LA treatment, and control. HFCS was given to the rats at a ratio of 30% of F30 corn syrup in drinking water for 10 weeks. α-LA treatment was given to the rats at a dose of 100 mg/kg/day orally for the last 6 weeks. At the end of the experiment, the rats were killed by cervical dislocation. The blood samples were collected for biochemical studies, and the aortic and cardiac tissues were collected for evaluation of oxidant–antioxidant system, tissue bath, and pathological examination. HFCS had increased the levels of malondialdehyde, creatine kinase MB, lactate dehydrogenase, and uric acid and showed significant structural changes in the heart of the rats by histopathology. Those changes were improved by α-LA treatment as it was found in this treatment group. Immunohistochemical expressions of tumor necrosis factor α and inducible nitric oxide synthase were increased in HFCS group, and these receptor levels were decreased by α-LA treatment. All the tissue bath studies supported these findings. Chronic consumption of HFCS caused several problems like cardiac and endothelial injury of aorta by hyperuricemia and induced oxidative stress and inflammation. α-LA treatment reduced uric acid levels, oxidative stress, and corrected vascular responses. α-LA can be added to cardiac drugs due to its cardiovascular protective effects against the cardiovascular diseases. |
| doi_str_mv | 10.1177/0960327115579431 |
| format | Article |
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The rats were randomly divided into three groups with each group containing eight rats. The groups include HFCS, HFCS + α-LA treatment, and control. HFCS was given to the rats at a ratio of 30% of F30 corn syrup in drinking water for 10 weeks. α-LA treatment was given to the rats at a dose of 100 mg/kg/day orally for the last 6 weeks. At the end of the experiment, the rats were killed by cervical dislocation. The blood samples were collected for biochemical studies, and the aortic and cardiac tissues were collected for evaluation of oxidant–antioxidant system, tissue bath, and pathological examination. HFCS had increased the levels of malondialdehyde, creatine kinase MB, lactate dehydrogenase, and uric acid and showed significant structural changes in the heart of the rats by histopathology. Those changes were improved by α-LA treatment as it was found in this treatment group. Immunohistochemical expressions of tumor necrosis factor α and inducible nitric oxide synthase were increased in HFCS group, and these receptor levels were decreased by α-LA treatment. All the tissue bath studies supported these findings. Chronic consumption of HFCS caused several problems like cardiac and endothelial injury of aorta by hyperuricemia and induced oxidative stress and inflammation. α-LA treatment reduced uric acid levels, oxidative stress, and corrected vascular responses. α-LA can be added to cardiac drugs due to its cardiovascular protective effects against the cardiovascular diseases.</description><identifier>ISSN: 0960-3271</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1177/0960327115579431</identifier><identifier>PMID: 25825413</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Antioxidants - metabolism ; Antioxidants - therapeutic use ; Aorta ; Aorta, Thoracic - pathology ; Biochemistry ; Cardiovascular diseases ; Cardiovascular system ; Cardiovascular System - drug effects ; Consumption ; Corn ; Coronary vessels ; Creatine ; Creatine kinase ; Damage assessment ; Dehydrogenase ; Dislocation ; Dislocations ; Drinking water ; Drugs ; Endothelium ; Endothelium, Vascular - pathology ; Female ; Fructose ; Heart ; Heart diseases ; High Fructose Corn Syrup - toxicity ; Histopathology ; Hyperuricemia ; Hyperuricemia - chemically induced ; Inflammation - chemically induced ; Inflammation - drug therapy ; Inflammation - pathology ; Injuries ; L-Lactate dehydrogenase ; Lactate dehydrogenase ; Lipoic acid ; Malondialdehyde ; Myocardium - pathology ; Nitric oxide ; Nitric-oxide synthase ; Oxidative stress ; Oxidative Stress - drug effects ; Rats ; Rats, Wistar ; Rodents ; Syrup ; Thioctic Acid - therapeutic use ; Tissues ; Tumor necrosis factor ; Uric acid ; Zea mays</subject><ispartof>Human & experimental toxicology, 2016-02, Vol.35 (2), p.194-204</ispartof><rights>The Author(s) 2015</rights><rights>The Author(s) 2015.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c351t-2b7cf841607e44b2eb2c7183c2fbe28c9198d4bc24d4729507a0efeb8df2597a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0960327115579431$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0960327115579431$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21966,27853,27924,27925,44945,45333</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/0960327115579431?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25825413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saygin, M</creatorcontrib><creatorcontrib>Asci, H</creatorcontrib><creatorcontrib>Cankara, FN</creatorcontrib><creatorcontrib>Bayram, D</creatorcontrib><creatorcontrib>Yesilot, S</creatorcontrib><creatorcontrib>Candan, IA</creatorcontrib><creatorcontrib>Alp, HH</creatorcontrib><title>The impact of high fructose on cardiovascular system: Role of α-lipoic acid</title><title>Human & experimental toxicology</title><addtitle>Hum Exp Toxicol</addtitle><description>The aim of this study was to evaluate the role of α-lipoic acid (α-LA) on oxidative damage and inflammation that occur in endothelium of aorta and heart while constant consumption of high-fructose corn syrup (HFCS). The rats were randomly divided into three groups with each group containing eight rats. The groups include HFCS, HFCS + α-LA treatment, and control. HFCS was given to the rats at a ratio of 30% of F30 corn syrup in drinking water for 10 weeks. α-LA treatment was given to the rats at a dose of 100 mg/kg/day orally for the last 6 weeks. At the end of the experiment, the rats were killed by cervical dislocation. The blood samples were collected for biochemical studies, and the aortic and cardiac tissues were collected for evaluation of oxidant–antioxidant system, tissue bath, and pathological examination. HFCS had increased the levels of malondialdehyde, creatine kinase MB, lactate dehydrogenase, and uric acid and showed significant structural changes in the heart of the rats by histopathology. Those changes were improved by α-LA treatment as it was found in this treatment group. Immunohistochemical expressions of tumor necrosis factor α and inducible nitric oxide synthase were increased in HFCS group, and these receptor levels were decreased by α-LA treatment. All the tissue bath studies supported these findings. Chronic consumption of HFCS caused several problems like cardiac and endothelial injury of aorta by hyperuricemia and induced oxidative stress and inflammation. α-LA treatment reduced uric acid levels, oxidative stress, and corrected vascular responses. α-LA can be added to cardiac drugs due to its cardiovascular protective effects against the cardiovascular diseases.</description><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - therapeutic use</subject><subject>Aorta</subject><subject>Aorta, Thoracic - pathology</subject><subject>Biochemistry</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular system</subject><subject>Cardiovascular System - drug effects</subject><subject>Consumption</subject><subject>Corn</subject><subject>Coronary vessels</subject><subject>Creatine</subject><subject>Creatine kinase</subject><subject>Damage assessment</subject><subject>Dehydrogenase</subject><subject>Dislocation</subject><subject>Dislocations</subject><subject>Drinking water</subject><subject>Drugs</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - pathology</subject><subject>Female</subject><subject>Fructose</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>High Fructose Corn Syrup - toxicity</subject><subject>Histopathology</subject><subject>Hyperuricemia</subject><subject>Hyperuricemia - chemically induced</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - pathology</subject><subject>Injuries</subject><subject>L-Lactate dehydrogenase</subject><subject>Lactate dehydrogenase</subject><subject>Lipoic acid</subject><subject>Malondialdehyde</subject><subject>Myocardium - pathology</subject><subject>Nitric oxide</subject><subject>Nitric-oxide synthase</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Syrup</subject><subject>Thioctic Acid - therapeutic use</subject><subject>Tissues</subject><subject>Tumor necrosis factor</subject><subject>Uric acid</subject><subject>Zea mays</subject><issn>0960-3271</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM9LwzAcxYMork7vnqTgxUs13_xokqMMf8HAyzyXNE22jnaZSSvsv7dlU2Tg6Xt4n_fel4fQNeB7ACEesMoxJQKAc6EYhROUABMiwwrTU5SMcjbqE3QR4xpjnCsO52hCuCScAU0QW6xsWrdbbbrUu3RVL1epC73pfLSp36RGh6r2XzqavtEhjbvY2fYSnTndRHt1uFP08fy0mL1m8_eXt9njPDOUQ5eRUhgnGeRYWMZKYktiBEhqiCstkUaBkhUrDWEVE0RxLDS2zpaycoQroekU3e1zt8F_9jZ2RVtHY5tGb6zvYwEiJzRnucQDenuErn0fNsN3BSgghBLJRwrvKRN8jMG6YhvqVoddAbgYFy2OFx0sN4fgvmxt9Wv4mXAAsj0Q9dL-af0v8Bt7Kntr</recordid><startdate>201602</startdate><enddate>201602</enddate><creator>Saygin, M</creator><creator>Asci, H</creator><creator>Cankara, FN</creator><creator>Bayram, D</creator><creator>Yesilot, S</creator><creator>Candan, IA</creator><creator>Alp, HH</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>SOI</scope></search><sort><creationdate>201602</creationdate><title>The impact of high fructose on cardiovascular system</title><author>Saygin, M ; Asci, H ; Cankara, FN ; Bayram, D ; Yesilot, S ; Candan, IA ; Alp, HH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-2b7cf841607e44b2eb2c7183c2fbe28c9198d4bc24d4729507a0efeb8df2597a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Antioxidants - metabolism</topic><topic>Antioxidants - therapeutic use</topic><topic>Aorta</topic><topic>Aorta, Thoracic - pathology</topic><topic>Biochemistry</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular system</topic><topic>Cardiovascular System - drug effects</topic><topic>Consumption</topic><topic>Corn</topic><topic>Coronary vessels</topic><topic>Creatine</topic><topic>Creatine kinase</topic><topic>Damage assessment</topic><topic>Dehydrogenase</topic><topic>Dislocation</topic><topic>Dislocations</topic><topic>Drinking water</topic><topic>Drugs</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - pathology</topic><topic>Female</topic><topic>Fructose</topic><topic>Heart</topic><topic>Heart diseases</topic><topic>High Fructose Corn Syrup - toxicity</topic><topic>Histopathology</topic><topic>Hyperuricemia</topic><topic>Hyperuricemia - chemically induced</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - pathology</topic><topic>Injuries</topic><topic>L-Lactate dehydrogenase</topic><topic>Lactate dehydrogenase</topic><topic>Lipoic acid</topic><topic>Malondialdehyde</topic><topic>Myocardium - pathology</topic><topic>Nitric oxide</topic><topic>Nitric-oxide synthase</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Syrup</topic><topic>Thioctic Acid - therapeutic use</topic><topic>Tissues</topic><topic>Tumor necrosis factor</topic><topic>Uric acid</topic><topic>Zea mays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saygin, M</creatorcontrib><creatorcontrib>Asci, H</creatorcontrib><creatorcontrib>Cankara, FN</creatorcontrib><creatorcontrib>Bayram, D</creatorcontrib><creatorcontrib>Yesilot, S</creatorcontrib><creatorcontrib>Candan, IA</creatorcontrib><creatorcontrib>Alp, HH</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Environment Abstracts</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Saygin, M</au><au>Asci, H</au><au>Cankara, FN</au><au>Bayram, D</au><au>Yesilot, S</au><au>Candan, IA</au><au>Alp, HH</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of high fructose on cardiovascular system: Role of α-lipoic acid</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>2016-02</date><risdate>2016</risdate><volume>35</volume><issue>2</issue><spage>194</spage><epage>204</epage><pages>194-204</pages><issn>0960-3271</issn><eissn>1477-0903</eissn><abstract>The aim of this study was to evaluate the role of α-lipoic acid (α-LA) on oxidative damage and inflammation that occur in endothelium of aorta and heart while constant consumption of high-fructose corn syrup (HFCS). The rats were randomly divided into three groups with each group containing eight rats. The groups include HFCS, HFCS + α-LA treatment, and control. HFCS was given to the rats at a ratio of 30% of F30 corn syrup in drinking water for 10 weeks. α-LA treatment was given to the rats at a dose of 100 mg/kg/day orally for the last 6 weeks. At the end of the experiment, the rats were killed by cervical dislocation. The blood samples were collected for biochemical studies, and the aortic and cardiac tissues were collected for evaluation of oxidant–antioxidant system, tissue bath, and pathological examination. HFCS had increased the levels of malondialdehyde, creatine kinase MB, lactate dehydrogenase, and uric acid and showed significant structural changes in the heart of the rats by histopathology. Those changes were improved by α-LA treatment as it was found in this treatment group. Immunohistochemical expressions of tumor necrosis factor α and inducible nitric oxide synthase were increased in HFCS group, and these receptor levels were decreased by α-LA treatment. All the tissue bath studies supported these findings. Chronic consumption of HFCS caused several problems like cardiac and endothelial injury of aorta by hyperuricemia and induced oxidative stress and inflammation. α-LA treatment reduced uric acid levels, oxidative stress, and corrected vascular responses. α-LA can be added to cardiac drugs due to its cardiovascular protective effects against the cardiovascular diseases.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>25825413</pmid><doi>10.1177/0960327115579431</doi><tpages>11</tpages></addata></record> |
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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Animals Antioxidants - metabolism Antioxidants - therapeutic use Aorta Aorta, Thoracic - pathology Biochemistry Cardiovascular diseases Cardiovascular system Cardiovascular System - drug effects Consumption Corn Coronary vessels Creatine Creatine kinase Damage assessment Dehydrogenase Dislocation Dislocations Drinking water Drugs Endothelium Endothelium, Vascular - pathology Female Fructose Heart Heart diseases High Fructose Corn Syrup - toxicity Histopathology Hyperuricemia Hyperuricemia - chemically induced Inflammation - chemically induced Inflammation - drug therapy Inflammation - pathology Injuries L-Lactate dehydrogenase Lactate dehydrogenase Lipoic acid Malondialdehyde Myocardium - pathology Nitric oxide Nitric-oxide synthase Oxidative stress Oxidative Stress - drug effects Rats Rats, Wistar Rodents Syrup Thioctic Acid - therapeutic use Tissues Tumor necrosis factor Uric acid Zea mays |
| title | The impact of high fructose on cardiovascular system: Role of α-lipoic acid |
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