GSK3 Deficiencies in Hematopoietic Stem Cells Initiate Pre-neoplastic State that Is Predictive of Clinical Outcomes of Human Acute Leukemia

Initial pathway alternations required for pathogenesis of human acute myeloid leukemia (AML) are poorly understood. Here we reveal that removal of glycogen synthase kinase-3α (GSK-3α) and GSK-3β dependency leads to aggressive AML. Although GSK-3α deletion alone has no effect, GSK-3β deletion in hema...

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Veröffentlicht in:	Cancer cell 2016-01, Vol.29 (1), p.61-74
Hauptverfasser:	Guezguez, Borhane, Almakadi, Mohammed, Benoit, Yannick D., Shapovalova, Zoya, Rahmig, Susann, Fiebig-Comyn, Aline, Casado, Fanny L., Tanasijevic, Borko, Bresolin, Silvia, Masetti, Riccardo, Doble, Bradley W., Bhatia, Mickie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Glycogen Synthase Kinase 3 - deficiency Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Hematopoietic Stem Cells - enzymology Humans Leukemia, Myeloid, Acute - enzymology Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - therapy Mice, Transgenic Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - physiology
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