The effect of hydrophobicity upon the direct mutagenicity of N-acyloxy-N-alkoxyamides—Bilinear dependence upon LogP

[Display omitted] •Highly hydrophobic, direct-acting N-acyloxy-N-alkoxyamides in S. typhimurium TA100 have been tested.•A bilinear relationship has been established for 55 congeners giving an optimum LogP of 6.4.•Deviations of certain mutagens from this relationship have been explained in terms of g...

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Veröffentlicht in:	Mutation research. Genetic toxicology and environmental mutagenesis 2016-01, Vol.795, p.41-50
Hauptverfasser:	Glover, Stephen A., Schumacher, Rhiannon R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ames test Amides - chemistry Amides - toxicity Bilinear QSAR Bioassays Deoxyribonucleic acid Direct-acting electrophilic amides DNA DNA binding DNA, Bacterial - metabolism Fatty Acids - chemistry Fatty Acids - toxicity Gram-negative bacteria Hydrophobic and Hydrophilic Interactions Hydrophobic effects Mutagenesis Mutagenicity Mutagenicity Tests Mutagens - chemistry Mutagens - toxicity Salmonella typhimurium Salmonella typhimurium - drug effects Structure-Activity Relationship
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