Developmental toxicity of hexachloronaphthalene in Wistar rats. A role of CYP1A1 expression

•The developmental toxicity of HxCN in Wistar rats was determined.•HxCN generated fetotoxic and embryotoxic effects.•LOAEL of HxCN for dams=0.3mg/kg b.w.•HxCN increases mRNA and protein expression of CYP1A1 in the livers and placentas.•Expression of CYP1A1 mRNA in the placenta appears to be marker o...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2015-12, Vol.58, p.93-103
Hauptverfasser:	Kilanowicz, Anna, Czekaj, Piotr, Sapota, Andrzej, Skrzypinska-Gawrysiak, Malgorzata, Bruchajzer, Elzbieta, Darago, Adam, Czech, Ewa, Plewka, Danuta, Wiaderkiewicz, Anna, Sitarek, Krystyna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CYP1A1 Cytochrome P-450 CYP1A1 - biosynthesis Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 Enzyme Inducers - toxicity Developmental toxicity Dose-Response Relationship, Drug Embryotoxicity Enzyme Induction Female Fetus - drug effects Fetus - enzymology Fetus - pathology Gestational Age Liver - drug effects Liver - embryology Liver - enzymology Male Naphthalenes - toxicity Organogenesis - drug effects Placenta Placenta - drug effects Placenta - enzymology Polychlorinated naphthalenes Pregnancy Rat Rats, Wistar Risk Assessment RNA, Messenger - biosynthesis RNA, Messenger - genetics
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