The importance of pelvic nerve fibers in endometriosis
Several lines of recent evidence suggest that pelvic innervation is altered in endometriosis-affected women, and there is a strong presumption that nerve fibers demonstrated in eutopic endometrium (of women with endometriosis) and in endometriotic lesions play roles in the generation of chronic pelv...
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| Veröffentlicht in: | Women's Health 2015-09, Vol.11 (5), p.611-618 |
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| creator | Miller, Emily J Fraser, Ian S |
| description | Several lines of recent evidence suggest that pelvic innervation is altered in endometriosis-affected women, and there is a strong presumption that nerve fibers demonstrated in eutopic endometrium (of women with endometriosis) and in endometriotic lesions play roles in the generation of chronic pelvic pain. The recent observation of sensory C, sensory A-delta, sympathetic and parasympathetic nerve fibers in the functional layer of endometrium of most women affected by endometriosis, but not demonstrated in most women who do not have endometriosis, was a surprise. Nerve fiber densities were also greatly increased in myometrium of women with endometriosis and in endometriotic lesions compared with normal peritoneum. Chronic pelvic pain is complex, and endometriosis is only one condition which contributes to this pain. The relationship between the presence of certain nerve fibers and the potential for local pain generation requires much future research. This paper reviews current knowledge concerning nerve fibers in endometrium, myometrium and endometriotic lesions, and discusses avenues of research that may improve our knowledge and lead to enriched understanding and management of endometriotic pain symptoms. |
| doi_str_mv | 10.2217/whe.15.47 |
| format | Article |
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The recent observation of sensory C, sensory A-delta, sympathetic and parasympathetic nerve fibers in the functional layer of endometrium of most women affected by endometriosis, but not demonstrated in most women who do not have endometriosis, was a surprise. Nerve fiber densities were also greatly increased in myometrium of women with endometriosis and in endometriotic lesions compared with normal peritoneum. Chronic pelvic pain is complex, and endometriosis is only one condition which contributes to this pain. The relationship between the presence of certain nerve fibers and the potential for local pain generation requires much future research. 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The recent observation of sensory C, sensory A-delta, sympathetic and parasympathetic nerve fibers in the functional layer of endometrium of most women affected by endometriosis, but not demonstrated in most women who do not have endometriosis, was a surprise. Nerve fiber densities were also greatly increased in myometrium of women with endometriosis and in endometriotic lesions compared with normal peritoneum. Chronic pelvic pain is complex, and endometriosis is only one condition which contributes to this pain. The relationship between the presence of certain nerve fibers and the potential for local pain generation requires much future research. This paper reviews current knowledge concerning nerve fibers in endometrium, myometrium and endometriotic lesions, and discusses avenues of research that may improve our knowledge and lead to enriched understanding and management of endometriotic pain symptoms.</description><subject>Adult</subject><subject>C-fibers</subject><subject>Chronic pain</subject><subject>Endometriosis</subject><subject>Endometriosis - pathology</subject><subject>Endometrium</subject><subject>Endometrium - innervation</subject><subject>Endometrium - pathology</subject><subject>Female</subject><subject>Fibers</subject><subject>Gynecology</subject><subject>Humans</subject><subject>Innervation</subject><subject>Lesions</subject><subject>Myometrium</subject><subject>Myometrium - innervation</subject><subject>Myometrium - pathology</subject><subject>nerve fibers</subject><subject>Nerve Fibers - metabolism</subject><subject>Neurogenesis</subject><subject>Neurons</subject><subject>Pain</subject><subject>Pain management</subject><subject>Parasympathetic nervous system</subject><subject>pelvic pain</subject><subject>Pelvic Pain - etiology</subject><subject>Pelvic Pain - pathology</subject><subject>Peritoneum</subject><subject>Pudendal nerve</subject><subject>unmyelinated</subject><subject>Women's Health</subject><subject>Womens health</subject><issn>1745-5057</issn><issn>1745-5065</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0cFK5TAUBuAgyuioC19gKAiDLu41J8lJ2qWIzgiCG12HJD3VyG17J2mVefupVGUQEVc5gS__IfyMHQBfCgHm5OmeloBLZTbYDhiFC-QaN99mNNvse84PnCtdKfjGtoWWoDTADtM391TEdt2nwXWBir4p1rR6jKHoKD1S0URPKRexK6ir-5aGFPsc8x7batwq0_7LuctuL85vzn4vrq5_XZ6dXi0CohgWFdQKXa0qD8LV3vuykjyUyF0FZKBCT7KsBXkZkAeJDhX5kkJotBIktdxlR3PuOvV_RsqDbWMOtFq5jvoxWzBaSNSoyy9QUWpdgoKJHr6jD_2YuukjFkpdaamU_FwZKaQQ0vBJHc8qpD7nRI1dp9i69NcCt8_t2KkdC2iVmeyPl8TRt1S_ydc6JvBzBtnd0X_rPkjCGTbjMCbKIdLUnp1vU3QMsaMP3v0DV6GnDQ</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Miller, Emily J</creator><creator>Fraser, Ian S</creator><general>Future Medicine Ltd</general><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20150901</creationdate><title>The importance of pelvic nerve fibers in endometriosis</title><author>Miller, Emily J ; Fraser, Ian S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c552t-91d45ad49b12adbbb8930c850a91e7195be38d2eb3c50c35a54eb8eccf642e363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>C-fibers</topic><topic>Chronic pain</topic><topic>Endometriosis</topic><topic>Endometriosis - pathology</topic><topic>Endometrium</topic><topic>Endometrium - innervation</topic><topic>Endometrium - pathology</topic><topic>Female</topic><topic>Fibers</topic><topic>Gynecology</topic><topic>Humans</topic><topic>Innervation</topic><topic>Lesions</topic><topic>Myometrium</topic><topic>Myometrium - innervation</topic><topic>Myometrium - pathology</topic><topic>nerve fibers</topic><topic>Nerve Fibers - metabolism</topic><topic>Neurogenesis</topic><topic>Neurons</topic><topic>Pain</topic><topic>Pain management</topic><topic>Parasympathetic nervous system</topic><topic>pelvic pain</topic><topic>Pelvic Pain - etiology</topic><topic>Pelvic Pain - pathology</topic><topic>Peritoneum</topic><topic>Pudendal nerve</topic><topic>unmyelinated</topic><topic>Women's Health</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller, Emily J</creatorcontrib><creatorcontrib>Fraser, Ian S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Women's Health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Miller, Emily J</au><au>Fraser, Ian S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The importance of pelvic nerve fibers in endometriosis</atitle><jtitle>Women's Health</jtitle><addtitle>Womens Health (Lond)</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>11</volume><issue>5</issue><spage>611</spage><epage>618</epage><pages>611-618</pages><issn>1745-5057</issn><eissn>1745-5065</eissn><abstract>Several lines of recent evidence suggest that pelvic innervation is altered in endometriosis-affected women, and there is a strong presumption that nerve fibers demonstrated in eutopic endometrium (of women with endometriosis) and in endometriotic lesions play roles in the generation of chronic pelvic pain. The recent observation of sensory C, sensory A-delta, sympathetic and parasympathetic nerve fibers in the functional layer of endometrium of most women affected by endometriosis, but not demonstrated in most women who do not have endometriosis, was a surprise. Nerve fiber densities were also greatly increased in myometrium of women with endometriosis and in endometriotic lesions compared with normal peritoneum. Chronic pelvic pain is complex, and endometriosis is only one condition which contributes to this pain. The relationship between the presence of certain nerve fibers and the potential for local pain generation requires much future research. 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| source | Sage Journals GOLD Open Access 2024 |
| subjects | Adult C-fibers Chronic pain Endometriosis Endometriosis - pathology Endometrium Endometrium - innervation Endometrium - pathology Female Fibers Gynecology Humans Innervation Lesions Myometrium Myometrium - innervation Myometrium - pathology nerve fibers Nerve Fibers - metabolism Neurogenesis Neurons Pain Pain management Parasympathetic nervous system pelvic pain Pelvic Pain - etiology Pelvic Pain - pathology Peritoneum Pudendal nerve unmyelinated Women's Health Womens health |
| title | The importance of pelvic nerve fibers in endometriosis |
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