Complestatin Exerts Antibacterial Activity by the Inhibition of Fatty Acid Synthesis

Bacterial enoyl-acyl carrier protein (ACP) reductase has been confirmed as a novel target for antibacterial drug development. In the screening of inhibitors of Staphylococcus aureus enoyl-ACP reductase (FabI), complestatin was isolated as a potent inhibitor of S. aureus FabI together with neuroprote...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2015/05/01, Vol.38(5), pp.715-721
Hauptverfasser:	Kwon, Yun-Ju, Kim, Hyun-Ju, Kim, Won-Gon
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use antibacterial Chlorophenols - pharmacology Chlorophenols - therapeutic use complestatin Drug Resistance - drug effects Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) - antagonists & inhibitors enoyl-acyl carrier protein reductase Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use fatty acid synthesis Fatty Acids - biosynthesis Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - growth & development Methicillin-Resistant Staphylococcus aureus - metabolism Microbial Sensitivity Tests Oligopeptides - pharmacology Oligopeptides - therapeutic use Peptides, Cyclic - pharmacology Peptides, Cyclic - therapeutic use Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - growth & development Staphylococcus aureus - metabolism Streptomyces Streptomyces - metabolism
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