RNAIII of the Staphylococcus aureus agr system activates global regulator MgrA by stabilizing mRNA

RNAIII, the effector of the agr quorum-sensing system, plays a key role in virulence gene regulation in Staphylococcus aureus, but how RNAIII transcriptionally regulates its downstream genes is not completely understood. Here, we show that RNAIII stabilizes mgrA mRNA, thereby increasing the producti...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-11, Vol.112 (45), p.14036-14041
Hauptverfasser:	Gupta, Ravi Kr, Luong, Thanh T, Lee, Chia Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Pairing Base Sequence Biological effects Biological Sciences Blotting, Western Electrophoretic Mobility Shift Assay Gene Components Gene Expression Regulation, Bacterial - genetics Genes Molecular Sequence Data Promoter Regions, Genetic - genetics Quorum Sensing - genetics Real-Time Polymerase Chain Reaction Regulatory Elements, Transcriptional - genetics Ribonucleic acid RNA RNA, Bacterial - metabolism Staphylococcus aureus Staphylococcus aureus - enzymology Staphylococcus infections
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