Urinary IP-10, MCP-1, NGAL, Cystatin-C, and KIM-1 Levels in Prenatally Diagnosed Unilateral Hydronephrosis: The Search for an Ideal Biomarker
Objective To investigate the urinary interferon gamma-induced protein 10 (IP-10), monocyte chemotactic protein 1 (MCP-1), neutrophil gelatinase-associated lipocalin (NGAL), cystatin-C, and kidney injury molecule-1 (KIM-1) levels in the management of children with prenatally diagnosed unilateral hydr...
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| Veröffentlicht in: | Urology (Ridgewood, N.J.) N.J.), 2016-01, Vol.87, p.185-192 |
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| creator | Karakus, Serkan Oktar, Tayfun Kucukgergin, Canan Kalelioglu, Ibrahim Seckin, Sule Atar, Arda Ander, Haluk Ziylan, Orhan |
| description | Objective To investigate the urinary interferon gamma-induced protein 10 (IP-10), monocyte chemotactic protein 1 (MCP-1), neutrophil gelatinase-associated lipocalin (NGAL), cystatin-C, and kidney injury molecule-1 (KIM-1) levels in the management of children with prenatally diagnosed unilateral hydronephrosis. Materials and Methods Twenty-seven children with antenatally diagnosed hydronephrosis were enrolled into the study. The controls consisted of 9 healthy children (6 boys, 3 girls; mean age: 41.77 ± 5.30 months). Thirteen children (9 boys, 4 girls; mean age: 48.46 ± 21.11 months) underwent pyeloplasty on follow-up; the remaining 14 (13 boys, 1 girl; mean age: 36.57 ± 14.02 months) were followed up after being diagnosed as having nonobstructive dilatation (NOD). The urinary marker levels were measured in the pyeloplasty, the NOD, and the control groups. Results The preoperative concentrations of IP-10, MCP-1, NGAL, and KIM-1 were significantly higher in the pyeloplasty group than in the control group ( P = .024, P = .002, P = .032, P = .001, respectively). The urinary IP-10 and MCP-1 levels were also significantly higher in the pyeloplasty group than in the NOD group ( P = .038, P = .037, respectively). There was no significant difference between the pyeloplasty group and the NOD group regarding urinary NGAL and KIM-1. In the pyeloplasty group, urinary marker levels except cystatin-C were significantly decreased in the postoperative period. Conclusion A decrease in levels of IP-10, MCP-1, NGAL, and KIM-1 after pyeloplasty may be used as a predictor of surgical outcome. Additionally, IP-10 and MCP-1 were superior to NGAL and KIM-1 in predicting who required surgery. |
| doi_str_mv | 10.1016/j.urology.2015.09.007 |
| format | Article |
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Materials and Methods Twenty-seven children with antenatally diagnosed hydronephrosis were enrolled into the study. The controls consisted of 9 healthy children (6 boys, 3 girls; mean age: 41.77 ± 5.30 months). Thirteen children (9 boys, 4 girls; mean age: 48.46 ± 21.11 months) underwent pyeloplasty on follow-up; the remaining 14 (13 boys, 1 girl; mean age: 36.57 ± 14.02 months) were followed up after being diagnosed as having nonobstructive dilatation (NOD). The urinary marker levels were measured in the pyeloplasty, the NOD, and the control groups. Results The preoperative concentrations of IP-10, MCP-1, NGAL, and KIM-1 were significantly higher in the pyeloplasty group than in the control group ( P = .024, P = .002, P = .032, P = .001, respectively). The urinary IP-10 and MCP-1 levels were also significantly higher in the pyeloplasty group than in the NOD group ( P = .038, P = .037, respectively). There was no significant difference between the pyeloplasty group and the NOD group regarding urinary NGAL and KIM-1. In the pyeloplasty group, urinary marker levels except cystatin-C were significantly decreased in the postoperative period. Conclusion A decrease in levels of IP-10, MCP-1, NGAL, and KIM-1 after pyeloplasty may be used as a predictor of surgical outcome. Additionally, IP-10 and MCP-1 were superior to NGAL and KIM-1 in predicting who required surgery.</description><identifier>ISSN: 0090-4295</identifier><identifier>EISSN: 1527-9995</identifier><identifier>DOI: 10.1016/j.urology.2015.09.007</identifier><identifier>PMID: 26505835</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acute-Phase Proteins - urine ; Biomarkers - urine ; Chemokine CCL2 - urine ; Chemokine CXCL10 - urine ; Child, Preschool ; Cystatin C - urine ; Enzyme-Linked Immunosorbent Assay ; Female ; Follow-Up Studies ; Hepatitis A Virus Cellular Receptor 1 ; Humans ; Hydronephrosis - diagnosis ; Hydronephrosis - surgery ; Hydronephrosis - urine ; Infant ; Lipocalin-2 ; Lipocalins - urine ; Male ; Membrane Glycoproteins - urine ; Prenatal Diagnosis - methods ; Preoperative Period ; Prospective Studies ; Proto-Oncogene Proteins - urine ; Receptors, Virus ; Reconstructive Surgical Procedures ; Urinalysis ; Urologic Surgical Procedures - methods ; Urology</subject><ispartof>Urology (Ridgewood, N.J.), 2016-01, Vol.87, p.185-192</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-9a166081355d806f85cad4fff31974adb73614bbbf18badfe88c13a658529feb3</citedby><cites>FETCH-LOGICAL-c486t-9a166081355d806f85cad4fff31974adb73614bbbf18badfe88c13a658529feb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.urology.2015.09.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26505835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karakus, Serkan</creatorcontrib><creatorcontrib>Oktar, Tayfun</creatorcontrib><creatorcontrib>Kucukgergin, Canan</creatorcontrib><creatorcontrib>Kalelioglu, Ibrahim</creatorcontrib><creatorcontrib>Seckin, Sule</creatorcontrib><creatorcontrib>Atar, Arda</creatorcontrib><creatorcontrib>Ander, Haluk</creatorcontrib><creatorcontrib>Ziylan, Orhan</creatorcontrib><title>Urinary IP-10, MCP-1, NGAL, Cystatin-C, and KIM-1 Levels in Prenatally Diagnosed Unilateral Hydronephrosis: The Search for an Ideal Biomarker</title><title>Urology (Ridgewood, N.J.)</title><addtitle>Urology</addtitle><description>Objective To investigate the urinary interferon gamma-induced protein 10 (IP-10), monocyte chemotactic protein 1 (MCP-1), neutrophil gelatinase-associated lipocalin (NGAL), cystatin-C, and kidney injury molecule-1 (KIM-1) levels in the management of children with prenatally diagnosed unilateral hydronephrosis. Materials and Methods Twenty-seven children with antenatally diagnosed hydronephrosis were enrolled into the study. The controls consisted of 9 healthy children (6 boys, 3 girls; mean age: 41.77 ± 5.30 months). Thirteen children (9 boys, 4 girls; mean age: 48.46 ± 21.11 months) underwent pyeloplasty on follow-up; the remaining 14 (13 boys, 1 girl; mean age: 36.57 ± 14.02 months) were followed up after being diagnosed as having nonobstructive dilatation (NOD). The urinary marker levels were measured in the pyeloplasty, the NOD, and the control groups. Results The preoperative concentrations of IP-10, MCP-1, NGAL, and KIM-1 were significantly higher in the pyeloplasty group than in the control group ( P = .024, P = .002, P = .032, P = .001, respectively). The urinary IP-10 and MCP-1 levels were also significantly higher in the pyeloplasty group than in the NOD group ( P = .038, P = .037, respectively). There was no significant difference between the pyeloplasty group and the NOD group regarding urinary NGAL and KIM-1. In the pyeloplasty group, urinary marker levels except cystatin-C were significantly decreased in the postoperative period. Conclusion A decrease in levels of IP-10, MCP-1, NGAL, and KIM-1 after pyeloplasty may be used as a predictor of surgical outcome. Additionally, IP-10 and MCP-1 were superior to NGAL and KIM-1 in predicting who required surgery.</description><subject>Acute-Phase Proteins - urine</subject><subject>Biomarkers - urine</subject><subject>Chemokine CCL2 - urine</subject><subject>Chemokine CXCL10 - urine</subject><subject>Child, Preschool</subject><subject>Cystatin C - urine</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hepatitis A Virus Cellular Receptor 1</subject><subject>Humans</subject><subject>Hydronephrosis - diagnosis</subject><subject>Hydronephrosis - surgery</subject><subject>Hydronephrosis - urine</subject><subject>Infant</subject><subject>Lipocalin-2</subject><subject>Lipocalins - urine</subject><subject>Male</subject><subject>Membrane Glycoproteins - urine</subject><subject>Prenatal Diagnosis - methods</subject><subject>Preoperative Period</subject><subject>Prospective Studies</subject><subject>Proto-Oncogene Proteins - urine</subject><subject>Receptors, Virus</subject><subject>Reconstructive Surgical Procedures</subject><subject>Urinalysis</subject><subject>Urologic Surgical Procedures - methods</subject><subject>Urology</subject><issn>0090-4295</issn><issn>1527-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksFuEzEQhlcIRNPCI4B85JAN9u7a6-VAVVJoI1Ko1EbiZnnt2capYwd7t9I-BO-MowQOXDjN5Zt_Zv5_suwNwTOCCXu_mQ3BW_8wzgpM6Aw3M4zrZ9mE0KLOm6ahz7MJxg3Oq6KhJ9lpjBuMMWOsfpmdFIxiyks6yX6tgnEyjGhxmxM8RTfzVKfo29XFcormY-xlb1w-nyLpNPq6uMkJWsIT2IiMQ7cBnOyltSO6NPLB-QgarZyxsocgLboedfAOduvgo4kf0P0a0B3IoNao8yFJooWGxH0yfivDI4RX2YtO2givj_UsW335fD-_zpffrxbzi2WuKs76vJGEMcxJSanmmHWcKqmrrutK0tSV1G1dMlK1bdsR3krdAeeKlJJRToumg7Y8y94ddHfB_xwg9mJrogJrpQM_REFqVpQVp7RMKD2gKh0RA3RiF0zadhQEi30SYiOOSYh9EgI3IiWR-t4eRwztFvTfrj_WJ-D8ACQz4clAEFEZcAq0CaB6ob3574iP_ygoa5xR0j7CCHHjh-CSi4KIWAgs7vbvsP8GQjHmNf9R_gZIcbBN</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Karakus, Serkan</creator><creator>Oktar, Tayfun</creator><creator>Kucukgergin, Canan</creator><creator>Kalelioglu, Ibrahim</creator><creator>Seckin, Sule</creator><creator>Atar, Arda</creator><creator>Ander, Haluk</creator><creator>Ziylan, Orhan</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160101</creationdate><title>Urinary IP-10, MCP-1, NGAL, Cystatin-C, and KIM-1 Levels in Prenatally Diagnosed Unilateral Hydronephrosis: The Search for an Ideal Biomarker</title><author>Karakus, Serkan ; Oktar, Tayfun ; Kucukgergin, Canan ; Kalelioglu, Ibrahim ; Seckin, Sule ; Atar, Arda ; Ander, Haluk ; Ziylan, Orhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-9a166081355d806f85cad4fff31974adb73614bbbf18badfe88c13a658529feb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acute-Phase Proteins - urine</topic><topic>Biomarkers - urine</topic><topic>Chemokine CCL2 - urine</topic><topic>Chemokine CXCL10 - urine</topic><topic>Child, Preschool</topic><topic>Cystatin C - urine</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hepatitis A Virus Cellular Receptor 1</topic><topic>Humans</topic><topic>Hydronephrosis - diagnosis</topic><topic>Hydronephrosis - surgery</topic><topic>Hydronephrosis - urine</topic><topic>Infant</topic><topic>Lipocalin-2</topic><topic>Lipocalins - urine</topic><topic>Male</topic><topic>Membrane Glycoproteins - urine</topic><topic>Prenatal Diagnosis - methods</topic><topic>Preoperative Period</topic><topic>Prospective Studies</topic><topic>Proto-Oncogene Proteins - urine</topic><topic>Receptors, Virus</topic><topic>Reconstructive Surgical Procedures</topic><topic>Urinalysis</topic><topic>Urologic Surgical Procedures - methods</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karakus, Serkan</creatorcontrib><creatorcontrib>Oktar, Tayfun</creatorcontrib><creatorcontrib>Kucukgergin, Canan</creatorcontrib><creatorcontrib>Kalelioglu, Ibrahim</creatorcontrib><creatorcontrib>Seckin, Sule</creatorcontrib><creatorcontrib>Atar, Arda</creatorcontrib><creatorcontrib>Ander, Haluk</creatorcontrib><creatorcontrib>Ziylan, Orhan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Urology (Ridgewood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karakus, Serkan</au><au>Oktar, Tayfun</au><au>Kucukgergin, Canan</au><au>Kalelioglu, Ibrahim</au><au>Seckin, Sule</au><au>Atar, Arda</au><au>Ander, Haluk</au><au>Ziylan, Orhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary IP-10, MCP-1, NGAL, Cystatin-C, and KIM-1 Levels in Prenatally Diagnosed Unilateral Hydronephrosis: The Search for an Ideal Biomarker</atitle><jtitle>Urology (Ridgewood, N.J.)</jtitle><addtitle>Urology</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>87</volume><spage>185</spage><epage>192</epage><pages>185-192</pages><issn>0090-4295</issn><eissn>1527-9995</eissn><abstract>Objective To investigate the urinary interferon gamma-induced protein 10 (IP-10), monocyte chemotactic protein 1 (MCP-1), neutrophil gelatinase-associated lipocalin (NGAL), cystatin-C, and kidney injury molecule-1 (KIM-1) levels in the management of children with prenatally diagnosed unilateral hydronephrosis. Materials and Methods Twenty-seven children with antenatally diagnosed hydronephrosis were enrolled into the study. The controls consisted of 9 healthy children (6 boys, 3 girls; mean age: 41.77 ± 5.30 months). Thirteen children (9 boys, 4 girls; mean age: 48.46 ± 21.11 months) underwent pyeloplasty on follow-up; the remaining 14 (13 boys, 1 girl; mean age: 36.57 ± 14.02 months) were followed up after being diagnosed as having nonobstructive dilatation (NOD). The urinary marker levels were measured in the pyeloplasty, the NOD, and the control groups. Results The preoperative concentrations of IP-10, MCP-1, NGAL, and KIM-1 were significantly higher in the pyeloplasty group than in the control group ( P = .024, P = .002, P = .032, P = .001, respectively). The urinary IP-10 and MCP-1 levels were also significantly higher in the pyeloplasty group than in the NOD group ( P = .038, P = .037, respectively). There was no significant difference between the pyeloplasty group and the NOD group regarding urinary NGAL and KIM-1. In the pyeloplasty group, urinary marker levels except cystatin-C were significantly decreased in the postoperative period. Conclusion A decrease in levels of IP-10, MCP-1, NGAL, and KIM-1 after pyeloplasty may be used as a predictor of surgical outcome. Additionally, IP-10 and MCP-1 were superior to NGAL and KIM-1 in predicting who required surgery.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26505835</pmid><doi>10.1016/j.urology.2015.09.007</doi><tpages>8</tpages></addata></record> |
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| subjects | Acute-Phase Proteins - urine Biomarkers - urine Chemokine CCL2 - urine Chemokine CXCL10 - urine Child, Preschool Cystatin C - urine Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Hepatitis A Virus Cellular Receptor 1 Humans Hydronephrosis - diagnosis Hydronephrosis - surgery Hydronephrosis - urine Infant Lipocalin-2 Lipocalins - urine Male Membrane Glycoproteins - urine Prenatal Diagnosis - methods Preoperative Period Prospective Studies Proto-Oncogene Proteins - urine Receptors, Virus Reconstructive Surgical Procedures Urinalysis Urologic Surgical Procedures - methods Urology |
| title | Urinary IP-10, MCP-1, NGAL, Cystatin-C, and KIM-1 Levels in Prenatally Diagnosed Unilateral Hydronephrosis: The Search for an Ideal Biomarker |
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