Reductions in eosinophil biomarkers by benralizumab in patients with asthma

Abstract Background Eosinophilic inflammation is frequently associated with increased asthma severity. Benralizumab is a humanized, afucosylated, anti–interleukin-5Rα monoclonal antibody that selectively depletes eosinophils and basophils through enhanced antibody-dependent cell-mediated cytotoxicit...

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Veröffentlicht in:	Respiratory medicine 2016-02, Vol.111, p.21-29
Hauptverfasser:	Pham, Tuyet-Hang, Damera, Gautam, Newbold, Paul, Ranade, Koustubh
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibodies, Monoclonal, Humanized - therapeutic use Antibody-Dependent Cell Cytotoxicity Asthma Asthma - blood Asthma - drug therapy Asthma - immunology Benralizumab Biomarker Biomarkers Biomarkers - blood Chemokines Clinical trials Cytokines Cytotoxicity Double-Blind Method Eosinophil Eosinophil Cationic Protein - blood Eosinophil-Derived Neurotoxin - blood Eosinophils - drug effects Eosinophils - immunology Eosinophils - pathology Family medical history Female Gangrene Humans IL-5 Inflammation Interleukin-5 - blood Interleukin-5 - immunology Male Middle Aged Proteins Pulmonary/Respiratory Studies Tumor necrosis factor-TNF Young Adult
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