Liver X receptor-α and miR-130a-3p regulate expression of sphingosine 1-phosphate receptor 2 in human umbilical vein endothelial cells

Recent studies have shown that activation of liver X receptors (LXRs) attenuates the development of atherosclerosis, not only by regulating lipid metabolism but also by suppressing inflammatory signaling. Sphingosine 1-phosphate receptor 2 (S1PR2), an important inflammatory gene product, plays a rol...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2016-02, Vol.310 (3), p.C216-C226
Hauptverfasser:	Fan, Aihui, Wang, Qian, Yuan, Yongjun, Cheng, Jilun, Chen, Lixian, Guo, Xiaohua, Li, Qiang, Chen, Bo, Huang, Xuliang, Huang, Qiaobing
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzoates - pharmacology Benzylamines - pharmacology Cells, Cultured Down-Regulation Electric Impedance Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Liver X Receptors Lysophospholipids - pharmacology MicroRNAs - genetics MicroRNAs - metabolism Orphan Nuclear Receptors - agonists Orphan Nuclear Receptors - genetics Orphan Nuclear Receptors - metabolism Permeability Receptors, Lysosphingolipid - agonists Receptors, Lysosphingolipid - genetics Receptors, Lysosphingolipid - metabolism RNA Interference Signal Transduction Sphingosine - analogs & derivatives Sphingosine - pharmacology Tight Junctions - drug effects Tight Junctions - metabolism Time Factors Transfection Tumor Necrosis Factor-alpha - pharmacology Up-Regulation Zonula Occludens-1 Protein - metabolism
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