Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins

GPCRs are involved in numerous physiologic functions and are important drug targets. Although the epithelial barrier is important for protection from invading pathogens, the correlation between GPCRs and epithelial barrier function remains unknown. Leukotriene B4 (LTB4) receptor type 2 (BLT2), mainl...

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Veröffentlicht in:	The FASEB journal 2016-02, Vol.30 (2), p.933-947
Hauptverfasser:	Ishii, Yumiko, Saeki, Kazuko, Liu, Min, Sasaki, Fumiyuki, Koga, Tomoaki, Kitajima, Keiko, Meno, Chikara, Okuno, Toshiaki, Yokomizo, Takehiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Claudin-4 - biosynthesis Claudin-4 - genetics claudin‐4 Dogs Fatty Acids, Unsaturated - pharmacology G protein Gene Expression Regulation - drug effects Gene Expression Regulation - physiology GPCR Humans Madin Darby Canine Kidney Cells MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Mice Mice, Knockout p38 MAPK p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Receptors, Leukotriene B4 - genetics Receptors, Leukotriene B4 - metabolism Skin - cytology Skin - metabolism Tight Junctions - genetics Tight Junctions - metabolism
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