Kupffer-cell-expressed transmembrane TNF-α is a major contributor to lipopolysaccharide and D-galactosamine-induced liver injury

Tumor necrosis factor (TNF)-α exists in two bioactive forms, a 26-kDa transmembrane form (tmTNF-α) and a 17-kDa soluble form (sTNF-α). sTNF-α has been recognized as a key regulator of hepatitis; however, serum sTNF-α disappears in mice during the development of severe liver injury, and high levels o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell and tissue research 2016-02, Vol.363 (2), p.371-383
Hauptverfasser:	Yang, Peng, Zhou, Wenjing, Li, Chenxi, Zhang, Meng, Jiang, Yaping, Jiang, Rui, Ba, Hongping, Li, Cheng, Wang, Jing, Yin, Bingjiao, Gong, Feili, Li, Zhuoya
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Apoptosis Biomedical and Life Sciences Biomedicine Cell Communication Cell Membrane - metabolism Cytokines - metabolism Fas Ligand Protein - metabolism Galactosamine Human Genetics Inflammation Mediators - metabolism Kupffer Cells - metabolism Kupffer Cells - pathology Lipopolysaccharides Liver - metabolism Liver - pathology Liver Diseases - blood Liver Diseases - metabolism Liver Diseases - pathology Male Mice, Inbred C57BL Molecular Medicine Proteomics Regular Article Transaminases - blood Tumor Necrosis Factor-alpha - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!