Circulating epithelial cell enumeration facilitates the identification and follow-up of a patient with early stage papillary thyroid microcarcinoma: A case report
This study examines whether the measurement of circulating epithelial cells (CECs) facilitates the identification and follow-up of a patient with thyroid cancer. A 29-y-old woman with no cancer history was enrolled as a healthy control in a CEC study. CECs were enriched from the peripheral blood by...
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| Veröffentlicht in: | Clinica chimica acta 2016-02, Vol.454, p.107-111 |
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| container_title | Clinica chimica acta |
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| creator | Hsieh, Chia-Hsun Lin, Hung-Chih Huang, Song-Bin Hsueh, Chuen Hsu, Hsung-Ling Wang, Hung-Ming Wu, Min-Hsien Tseng, Ching-Ping Lin, Jen-Der |
| description | This study examines whether the measurement of circulating epithelial cells (CECs) facilitates the identification and follow-up of a patient with thyroid cancer.
A 29-y-old woman with no cancer history was enrolled as a healthy control in a CEC study. CECs were enriched from the peripheral blood by the negative selection system PowerMag. Various medical examinations were performed on the patient to establish the diagnosis and to follow-up her disease status during treatment.
This patient had unexpectedly high CEC counts that were sustained for more than two weeks. Thyroid gland ultra-sonography revealed lesions in the left lobe that could not be confirmed as cancer by magnetic resonance imaging, 18F–fludeoxyglucose-positron emission tomography–computed tomography or cytopathological analysis, but were histologically confirmed after thyroidectomy as papillary thyroid microcarcinoma. Both the CEC count and serum thyroglobulin (Tg) concentration were significantly decreased after thyroidectomy, and they and the patient's disease status were correlated during remnant ablation therapy. The CEC count returned to normal when the patient was disease-free 10months after thyroidectomy.
CEC testing facilitates the identification of individuals at risk for cancer. Longitudinal follow-up of the CEC count may complement serum Tg testing for monitoring the status of patients with thyroid cancer.
•An individual with no sign of cancer had persistently high CEC counts.•Follow-up medical examinations revealed that the patient had early stage PTMC.•The CEC counts were correlated with serum Tg and the patient's disease status.•CEC testing facilitates the identification and management of patients with PTMC. |
| doi_str_mv | 10.1016/j.cca.2015.12.030 |
| format | Article |
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A 29-y-old woman with no cancer history was enrolled as a healthy control in a CEC study. CECs were enriched from the peripheral blood by the negative selection system PowerMag. Various medical examinations were performed on the patient to establish the diagnosis and to follow-up her disease status during treatment.
This patient had unexpectedly high CEC counts that were sustained for more than two weeks. Thyroid gland ultra-sonography revealed lesions in the left lobe that could not be confirmed as cancer by magnetic resonance imaging, 18F–fludeoxyglucose-positron emission tomography–computed tomography or cytopathological analysis, but were histologically confirmed after thyroidectomy as papillary thyroid microcarcinoma. Both the CEC count and serum thyroglobulin (Tg) concentration were significantly decreased after thyroidectomy, and they and the patient's disease status were correlated during remnant ablation therapy. The CEC count returned to normal when the patient was disease-free 10months after thyroidectomy.
CEC testing facilitates the identification of individuals at risk for cancer. Longitudinal follow-up of the CEC count may complement serum Tg testing for monitoring the status of patients with thyroid cancer.
•An individual with no sign of cancer had persistently high CEC counts.•Follow-up medical examinations revealed that the patient had early stage PTMC.•The CEC counts were correlated with serum Tg and the patient's disease status.•CEC testing facilitates the identification and management of patients with PTMC.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/j.cca.2015.12.030</identifier><identifier>PMID: 26751809</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Carcinoma, Papillary - blood ; Carcinoma, Papillary - diagnosis ; Carcinoma, Papillary - pathology ; Carcinoma, Papillary - surgery ; Cell Count ; Circulating epithelial cells ; Epithelial cell adhesion molecule ; Epithelial Cells - pathology ; Female ; Fluorodeoxyglucose F18 ; Humans ; Papillary thyroid microcarcinoma ; Positron-Emission Tomography ; Thyroglobulin ; Thyroglobulin - blood ; Thyroid Neoplasms - blood ; Thyroid Neoplasms - diagnosis ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - surgery ; Thyroidectomy ; Tomography, X-Ray Computed</subject><ispartof>Clinica chimica acta, 2016-02, Vol.454, p.107-111</ispartof><rights>2016 Elsevier B.V.</rights><rights>Copyright © 2016 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-1a312e98433b197ed918625a345e80a07f5c9d4663ed2f1d98b2ececb646ec4d3</citedby><cites>FETCH-LOGICAL-c353t-1a312e98433b197ed918625a345e80a07f5c9d4663ed2f1d98b2ececb646ec4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S000989811530098X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26751809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hsieh, Chia-Hsun</creatorcontrib><creatorcontrib>Lin, Hung-Chih</creatorcontrib><creatorcontrib>Huang, Song-Bin</creatorcontrib><creatorcontrib>Hsueh, Chuen</creatorcontrib><creatorcontrib>Hsu, Hsung-Ling</creatorcontrib><creatorcontrib>Wang, Hung-Ming</creatorcontrib><creatorcontrib>Wu, Min-Hsien</creatorcontrib><creatorcontrib>Tseng, Ching-Ping</creatorcontrib><creatorcontrib>Lin, Jen-Der</creatorcontrib><title>Circulating epithelial cell enumeration facilitates the identification and follow-up of a patient with early stage papillary thyroid microcarcinoma: A case report</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>This study examines whether the measurement of circulating epithelial cells (CECs) facilitates the identification and follow-up of a patient with thyroid cancer.
A 29-y-old woman with no cancer history was enrolled as a healthy control in a CEC study. CECs were enriched from the peripheral blood by the negative selection system PowerMag. Various medical examinations were performed on the patient to establish the diagnosis and to follow-up her disease status during treatment.
This patient had unexpectedly high CEC counts that were sustained for more than two weeks. Thyroid gland ultra-sonography revealed lesions in the left lobe that could not be confirmed as cancer by magnetic resonance imaging, 18F–fludeoxyglucose-positron emission tomography–computed tomography or cytopathological analysis, but were histologically confirmed after thyroidectomy as papillary thyroid microcarcinoma. Both the CEC count and serum thyroglobulin (Tg) concentration were significantly decreased after thyroidectomy, and they and the patient's disease status were correlated during remnant ablation therapy. The CEC count returned to normal when the patient was disease-free 10months after thyroidectomy.
CEC testing facilitates the identification of individuals at risk for cancer. Longitudinal follow-up of the CEC count may complement serum Tg testing for monitoring the status of patients with thyroid cancer.
•An individual with no sign of cancer had persistently high CEC counts.•Follow-up medical examinations revealed that the patient had early stage PTMC.•The CEC counts were correlated with serum Tg and the patient's disease status.•CEC testing facilitates the identification and management of patients with PTMC.</description><subject>Adult</subject><subject>Carcinoma, Papillary - blood</subject><subject>Carcinoma, Papillary - diagnosis</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Carcinoma, Papillary - surgery</subject><subject>Cell Count</subject><subject>Circulating epithelial cells</subject><subject>Epithelial cell adhesion molecule</subject><subject>Epithelial Cells - pathology</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Papillary thyroid microcarcinoma</subject><subject>Positron-Emission Tomography</subject><subject>Thyroglobulin</subject><subject>Thyroglobulin - blood</subject><subject>Thyroid Neoplasms - blood</subject><subject>Thyroid Neoplasms - diagnosis</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroidectomy</subject><subject>Tomography, X-Ray Computed</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUha2Kqh0GHoAN8pJNgn8SJ4FVNQJaqRKbsrbu2DfFIycOtkM1r8OT1qMpLFlZV-e7R77nEPKOs5ozrj4eamOgFoy3NRc1k-yCbHjfyUo2g3hFNoyxoeqHnl-T1ykdytgwxa_ItVBdy3s2bMifnYtm9ZDd_EhxcfknegeeGvSe4rxOGIsWZjqCcd5lyJhogaizOGc3OnOWYbZ0DN6Hp2pdaBgp0KUohaFPxZQiRH-kKcMjFmFx3kM8FqNjDM7SyZkYDETj5jDBJ3pDDSSkEZcQ8xtyOYJP-Pbl3ZIfX7887G6r--_f7nY395WRrcwVB8kFDn0j5Z4PHdqB90q0IJsWewasG1sz2EYpiVaM3A79XqBBs1eNQtNYuSUfzr5LDL9WTFlPLp1ygBnDmjTvlJCNYCXgLeFntHw7pYijXqKbykWaM32qRh90qUafqtFc6FJN2Xn_Yr_uJ7T_Nv52UYDPZwDLkb8dRp1MCdCgdRFN1ja4_9g_Azh3oqY</recordid><startdate>20160215</startdate><enddate>20160215</enddate><creator>Hsieh, Chia-Hsun</creator><creator>Lin, Hung-Chih</creator><creator>Huang, Song-Bin</creator><creator>Hsueh, Chuen</creator><creator>Hsu, Hsung-Ling</creator><creator>Wang, Hung-Ming</creator><creator>Wu, Min-Hsien</creator><creator>Tseng, Ching-Ping</creator><creator>Lin, Jen-Der</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160215</creationdate><title>Circulating epithelial cell enumeration facilitates the identification and follow-up of a patient with early stage papillary thyroid microcarcinoma: A case report</title><author>Hsieh, Chia-Hsun ; Lin, Hung-Chih ; Huang, Song-Bin ; Hsueh, Chuen ; Hsu, Hsung-Ling ; Wang, Hung-Ming ; Wu, Min-Hsien ; Tseng, Ching-Ping ; Lin, Jen-Der</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-1a312e98433b197ed918625a345e80a07f5c9d4663ed2f1d98b2ececb646ec4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Carcinoma, Papillary - blood</topic><topic>Carcinoma, Papillary - diagnosis</topic><topic>Carcinoma, Papillary - pathology</topic><topic>Carcinoma, Papillary - surgery</topic><topic>Cell Count</topic><topic>Circulating epithelial cells</topic><topic>Epithelial cell adhesion molecule</topic><topic>Epithelial Cells - pathology</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Papillary thyroid microcarcinoma</topic><topic>Positron-Emission Tomography</topic><topic>Thyroglobulin</topic><topic>Thyroglobulin - blood</topic><topic>Thyroid Neoplasms - blood</topic><topic>Thyroid Neoplasms - diagnosis</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroidectomy</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsieh, Chia-Hsun</creatorcontrib><creatorcontrib>Lin, Hung-Chih</creatorcontrib><creatorcontrib>Huang, Song-Bin</creatorcontrib><creatorcontrib>Hsueh, Chuen</creatorcontrib><creatorcontrib>Hsu, Hsung-Ling</creatorcontrib><creatorcontrib>Wang, Hung-Ming</creatorcontrib><creatorcontrib>Wu, Min-Hsien</creatorcontrib><creatorcontrib>Tseng, Ching-Ping</creatorcontrib><creatorcontrib>Lin, Jen-Der</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsieh, Chia-Hsun</au><au>Lin, Hung-Chih</au><au>Huang, Song-Bin</au><au>Hsueh, Chuen</au><au>Hsu, Hsung-Ling</au><au>Wang, Hung-Ming</au><au>Wu, Min-Hsien</au><au>Tseng, Ching-Ping</au><au>Lin, Jen-Der</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating epithelial cell enumeration facilitates the identification and follow-up of a patient with early stage papillary thyroid microcarcinoma: A case report</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>2016-02-15</date><risdate>2016</risdate><volume>454</volume><spage>107</spage><epage>111</epage><pages>107-111</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>This study examines whether the measurement of circulating epithelial cells (CECs) facilitates the identification and follow-up of a patient with thyroid cancer.
A 29-y-old woman with no cancer history was enrolled as a healthy control in a CEC study. CECs were enriched from the peripheral blood by the negative selection system PowerMag. Various medical examinations were performed on the patient to establish the diagnosis and to follow-up her disease status during treatment.
This patient had unexpectedly high CEC counts that were sustained for more than two weeks. Thyroid gland ultra-sonography revealed lesions in the left lobe that could not be confirmed as cancer by magnetic resonance imaging, 18F–fludeoxyglucose-positron emission tomography–computed tomography or cytopathological analysis, but were histologically confirmed after thyroidectomy as papillary thyroid microcarcinoma. Both the CEC count and serum thyroglobulin (Tg) concentration were significantly decreased after thyroidectomy, and they and the patient's disease status were correlated during remnant ablation therapy. The CEC count returned to normal when the patient was disease-free 10months after thyroidectomy.
CEC testing facilitates the identification of individuals at risk for cancer. Longitudinal follow-up of the CEC count may complement serum Tg testing for monitoring the status of patients with thyroid cancer.
•An individual with no sign of cancer had persistently high CEC counts.•Follow-up medical examinations revealed that the patient had early stage PTMC.•The CEC counts were correlated with serum Tg and the patient's disease status.•CEC testing facilitates the identification and management of patients with PTMC.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26751809</pmid><doi>10.1016/j.cca.2015.12.030</doi><tpages>5</tpages></addata></record> |
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| ispartof | Clinica chimica acta, 2016-02, Vol.454, p.107-111 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Carcinoma, Papillary - blood Carcinoma, Papillary - diagnosis Carcinoma, Papillary - pathology Carcinoma, Papillary - surgery Cell Count Circulating epithelial cells Epithelial cell adhesion molecule Epithelial Cells - pathology Female Fluorodeoxyglucose F18 Humans Papillary thyroid microcarcinoma Positron-Emission Tomography Thyroglobulin Thyroglobulin - blood Thyroid Neoplasms - blood Thyroid Neoplasms - diagnosis Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery Thyroidectomy Tomography, X-Ray Computed |
| title | Circulating epithelial cell enumeration facilitates the identification and follow-up of a patient with early stage papillary thyroid microcarcinoma: A case report |
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