Antimicrobial activity of the synthetic peptide Lys-a1 against oral streptococci
► The MIC values ranged from 3.9 to 125μgmL−1, while the MBC values ranged from 3.9 to 500μgmL−1. ► The peptide Lys-a1 demonstrated the potential to inhibit biofilm formation in all bacterial species tested. ► Streptococcus parasanguinis showed the greatest susceptibility to the peptide, reducing th...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2013-04, Vol.42, p.78-83 |
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| creator | da Silva, Bruno Rocha de Freitas, Victor Aragão Abreu Carneiro, Victor Alves Arruda, Francisco Vassiliepe Sousa Lorenzón, Esteban Nicolás de Aguiar, Andréa Silvia Walter Cilli, Eduardo Maffud Cavada, Benildo Sousa Teixeira, Edson Holanda |
| description | ► The MIC values ranged from 3.9 to 125μgmL−1, while the MBC values ranged from 3.9 to 500μgmL−1. ► The peptide Lys-a1 demonstrated the potential to inhibit biofilm formation in all bacterial species tested. ► Streptococcus parasanguinis showed the greatest susceptibility to the peptide, reducing the number of viable cells at 1.9μgmL−1. ► The antimicrobial peptide Lys-a1 has shown remarkable antimicrobial and antibiofilm activity.
The peptide LYS-[TRP6]-Hy-A1 (Lys-a1) is a synthetic derivative of the peptide Hy-A1, initially isolated from the frog species Hypsiboas albopunctatus. According to previous research, it is a molecule with broad antimicrobial activity. The objective of this study was to evaluate the antimicrobial activity of the synthetic peptide Lys-a1 (KIFGAIWPLALGALKNLIK-NH2) on the planktonic and biofilm growth of oral bacteria. The methods used to evaluate antimicrobial activity include the following: determination of the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) in microtiter plates for growth in suspension and quantification of biomass by crystal violet staining and counting of colony forming units for biofilm growth. The microorganisms Streptococcus oralis, Streptococcus sanguinis, Streptococcus parasanguinis, Streptococcus salivarius, Streptococcus mutans and Streptococcus sobrinus were grown in Brain Heart Infusion broth at 37°C under atmospheric pressure with 10% CO2. The peptide was solubilized in 0.1% acetic acid (v/v) at various concentrations (500–1.9μgmL−1). Chlorhexidine gluconate 0.12% was used as the positive control, and BHI culture medium was used as the negative control. The tested peptide demonstrated a remarkable antimicrobial effect, inhibiting the planktonic and biofilm growth of all strains tested, even at low concentrations. Thus, the peptide Lys-a1 is an important source for potential antimicrobial agents, especially for the control and prevention of microbial biofilms, which is one of the most important factors in cariogenic processes. |
| doi_str_mv | 10.1016/j.peptides.2012.12.001 |
| format | Article |
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The peptide LYS-[TRP6]-Hy-A1 (Lys-a1) is a synthetic derivative of the peptide Hy-A1, initially isolated from the frog species Hypsiboas albopunctatus. According to previous research, it is a molecule with broad antimicrobial activity. The objective of this study was to evaluate the antimicrobial activity of the synthetic peptide Lys-a1 (KIFGAIWPLALGALKNLIK-NH2) on the planktonic and biofilm growth of oral bacteria. The methods used to evaluate antimicrobial activity include the following: determination of the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) in microtiter plates for growth in suspension and quantification of biomass by crystal violet staining and counting of colony forming units for biofilm growth. The microorganisms Streptococcus oralis, Streptococcus sanguinis, Streptococcus parasanguinis, Streptococcus salivarius, Streptococcus mutans and Streptococcus sobrinus were grown in Brain Heart Infusion broth at 37°C under atmospheric pressure with 10% CO2. The peptide was solubilized in 0.1% acetic acid (v/v) at various concentrations (500–1.9μgmL−1). Chlorhexidine gluconate 0.12% was used as the positive control, and BHI culture medium was used as the negative control. The tested peptide demonstrated a remarkable antimicrobial effect, inhibiting the planktonic and biofilm growth of all strains tested, even at low concentrations. Thus, the peptide Lys-a1 is an important source for potential antimicrobial agents, especially for the control and prevention of microbial biofilms, which is one of the most important factors in cariogenic processes.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/j.peptides.2012.12.001</identifier><identifier>PMID: 23340019</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>acetic acid ; Amino Acid Sequence ; Amphibian Proteins - chemistry ; Anti-Infective Agents - chemistry ; Anti-Infective Agents - pharmacology ; anti-infective properties ; Antiinfectives and antibacterials ; Antimicrobial peptide ; antimicrobials ; Anura ; atmospheric pressure ; Bacteria ; biofilm ; Biofilms ; Biofilms - drug effects ; Biomass ; carbon dioxide ; chlorhexidine ; Colony Count, Microbial ; culture media ; Dental caries ; Derivatives ; frogs ; gentian violet ; gluconates ; Hypsiboas ; Microbial Sensitivity Tests ; Microorganisms ; minimum inhibitory concentration ; Molecular Sequence Data ; Mouth - microbiology ; Peptides ; Peptides - chemistry ; Peptides - pharmacology ; solubilization ; Streptococcus ; Streptococcus - drug effects ; Streptococcus mutans ; Streptococcus mutans - drug effects ; Streptococcus oralis ; Streptococcus parasanguinis ; Streptococcus salivarius ; Streptococcus sanguinis ; Streptococcus sanguis - drug effects ; Streptococcus sobrinus ; Streptococcus sobrinus - drug effects ; synthetic peptides</subject><ispartof>Peptides (New York, N.Y. : 1980), 2013-04, Vol.42, p.78-83</ispartof><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-597515c3ce87efc1ff19bc5eaf2325027f118c2892ecb2401f17748fc86303083</citedby><cites>FETCH-LOGICAL-c458t-597515c3ce87efc1ff19bc5eaf2325027f118c2892ecb2401f17748fc86303083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.peptides.2012.12.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23340019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>da Silva, Bruno Rocha</creatorcontrib><creatorcontrib>de Freitas, Victor Aragão Abreu</creatorcontrib><creatorcontrib>Carneiro, Victor Alves</creatorcontrib><creatorcontrib>Arruda, Francisco Vassiliepe Sousa</creatorcontrib><creatorcontrib>Lorenzón, Esteban Nicolás</creatorcontrib><creatorcontrib>de Aguiar, Andréa Silvia Walter</creatorcontrib><creatorcontrib>Cilli, Eduardo Maffud</creatorcontrib><creatorcontrib>Cavada, Benildo Sousa</creatorcontrib><creatorcontrib>Teixeira, Edson Holanda</creatorcontrib><title>Antimicrobial activity of the synthetic peptide Lys-a1 against oral streptococci</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>► The MIC values ranged from 3.9 to 125μgmL−1, while the MBC values ranged from 3.9 to 500μgmL−1. ► The peptide Lys-a1 demonstrated the potential to inhibit biofilm formation in all bacterial species tested. ► Streptococcus parasanguinis showed the greatest susceptibility to the peptide, reducing the number of viable cells at 1.9μgmL−1. ► The antimicrobial peptide Lys-a1 has shown remarkable antimicrobial and antibiofilm activity.
The peptide LYS-[TRP6]-Hy-A1 (Lys-a1) is a synthetic derivative of the peptide Hy-A1, initially isolated from the frog species Hypsiboas albopunctatus. According to previous research, it is a molecule with broad antimicrobial activity. The objective of this study was to evaluate the antimicrobial activity of the synthetic peptide Lys-a1 (KIFGAIWPLALGALKNLIK-NH2) on the planktonic and biofilm growth of oral bacteria. The methods used to evaluate antimicrobial activity include the following: determination of the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) in microtiter plates for growth in suspension and quantification of biomass by crystal violet staining and counting of colony forming units for biofilm growth. The microorganisms Streptococcus oralis, Streptococcus sanguinis, Streptococcus parasanguinis, Streptococcus salivarius, Streptococcus mutans and Streptococcus sobrinus were grown in Brain Heart Infusion broth at 37°C under atmospheric pressure with 10% CO2. The peptide was solubilized in 0.1% acetic acid (v/v) at various concentrations (500–1.9μgmL−1). Chlorhexidine gluconate 0.12% was used as the positive control, and BHI culture medium was used as the negative control. The tested peptide demonstrated a remarkable antimicrobial effect, inhibiting the planktonic and biofilm growth of all strains tested, even at low concentrations. Thus, the peptide Lys-a1 is an important source for potential antimicrobial agents, especially for the control and prevention of microbial biofilms, which is one of the most important factors in cariogenic processes.</description><subject>acetic acid</subject><subject>Amino Acid Sequence</subject><subject>Amphibian Proteins - chemistry</subject><subject>Anti-Infective Agents - chemistry</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>anti-infective properties</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial peptide</subject><subject>antimicrobials</subject><subject>Anura</subject><subject>atmospheric pressure</subject><subject>Bacteria</subject><subject>biofilm</subject><subject>Biofilms</subject><subject>Biofilms - drug effects</subject><subject>Biomass</subject><subject>carbon dioxide</subject><subject>chlorhexidine</subject><subject>Colony Count, Microbial</subject><subject>culture media</subject><subject>Dental caries</subject><subject>Derivatives</subject><subject>frogs</subject><subject>gentian violet</subject><subject>gluconates</subject><subject>Hypsiboas</subject><subject>Microbial Sensitivity Tests</subject><subject>Microorganisms</subject><subject>minimum inhibitory concentration</subject><subject>Molecular Sequence Data</subject><subject>Mouth - microbiology</subject><subject>Peptides</subject><subject>Peptides - chemistry</subject><subject>Peptides - pharmacology</subject><subject>solubilization</subject><subject>Streptococcus</subject><subject>Streptococcus - drug effects</subject><subject>Streptococcus mutans</subject><subject>Streptococcus mutans - drug effects</subject><subject>Streptococcus oralis</subject><subject>Streptococcus parasanguinis</subject><subject>Streptococcus salivarius</subject><subject>Streptococcus sanguinis</subject><subject>Streptococcus sanguis - drug effects</subject><subject>Streptococcus sobrinus</subject><subject>Streptococcus sobrinus - drug effects</subject><subject>synthetic peptides</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1uUzEQhS0EomnhFcpdsrnB43_vqKoClSKBBF1bjjMujpLrYDuV8vY4Ssq2SCPNYr4zMzqHkGugc6CgPq3nO9y1tMI6ZxTYvBel8IrMwGg-SlD2NZlRsGq02sAFuax1TSkVwpq35IJxLjpuZ-THzdTSNoWSl8lvBh9aekrtMOQ4tN841MPUW0thOJ8bFoc6ehj8o09TbUMuXVVb6dMccgjpHXkT_abi-3O_Ig9f7n7dfhsX37_e394sxiCkaaO0WoIMPKDRGAPECHYZJPrIOJOU6QhgAjOWYVgyQSGC1sLEYBSnnBp-RT6e9u5K_rPH2tw21YCbjZ8w76sDrRgIofR_oJJRbqyS7GWUS2qssIJ2VJ3Q7l2tBaPblbT15eCAumNGbu2eM3LHjFyvbnoXXp9v7JdbXP2TPYfSgQ8nIPrs_GNJ1T387BtUD5AZbo_E5xOB3eGnhMXVkHAKuEoFQ3OrnF764i8L-q4H</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>da Silva, Bruno Rocha</creator><creator>de Freitas, Victor Aragão Abreu</creator><creator>Carneiro, Victor Alves</creator><creator>Arruda, Francisco Vassiliepe Sousa</creator><creator>Lorenzón, Esteban Nicolás</creator><creator>de Aguiar, Andréa Silvia Walter</creator><creator>Cilli, Eduardo Maffud</creator><creator>Cavada, Benildo Sousa</creator><creator>Teixeira, Edson Holanda</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7U5</scope><scope>L7M</scope></search><sort><creationdate>20130401</creationdate><title>Antimicrobial activity of the synthetic peptide Lys-a1 against oral streptococci</title><author>da Silva, Bruno Rocha ; de Freitas, Victor Aragão Abreu ; Carneiro, Victor Alves ; Arruda, Francisco Vassiliepe Sousa ; Lorenzón, Esteban Nicolás ; de Aguiar, Andréa Silvia Walter ; Cilli, Eduardo Maffud ; Cavada, Benildo Sousa ; Teixeira, Edson Holanda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-597515c3ce87efc1ff19bc5eaf2325027f118c2892ecb2401f17748fc86303083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>acetic acid</topic><topic>Amino Acid Sequence</topic><topic>Amphibian Proteins - chemistry</topic><topic>Anti-Infective Agents - chemistry</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>anti-infective properties</topic><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial peptide</topic><topic>antimicrobials</topic><topic>Anura</topic><topic>atmospheric pressure</topic><topic>Bacteria</topic><topic>biofilm</topic><topic>Biofilms</topic><topic>Biofilms - drug effects</topic><topic>Biomass</topic><topic>carbon dioxide</topic><topic>chlorhexidine</topic><topic>Colony Count, Microbial</topic><topic>culture media</topic><topic>Dental caries</topic><topic>Derivatives</topic><topic>frogs</topic><topic>gentian violet</topic><topic>gluconates</topic><topic>Hypsiboas</topic><topic>Microbial Sensitivity Tests</topic><topic>Microorganisms</topic><topic>minimum inhibitory concentration</topic><topic>Molecular Sequence Data</topic><topic>Mouth - microbiology</topic><topic>Peptides</topic><topic>Peptides - chemistry</topic><topic>Peptides - pharmacology</topic><topic>solubilization</topic><topic>Streptococcus</topic><topic>Streptococcus - drug effects</topic><topic>Streptococcus mutans</topic><topic>Streptococcus mutans - drug effects</topic><topic>Streptococcus oralis</topic><topic>Streptococcus parasanguinis</topic><topic>Streptococcus salivarius</topic><topic>Streptococcus sanguinis</topic><topic>Streptococcus sanguis - drug effects</topic><topic>Streptococcus sobrinus</topic><topic>Streptococcus sobrinus - drug effects</topic><topic>synthetic peptides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>da Silva, Bruno Rocha</creatorcontrib><creatorcontrib>de Freitas, Victor Aragão Abreu</creatorcontrib><creatorcontrib>Carneiro, Victor Alves</creatorcontrib><creatorcontrib>Arruda, Francisco Vassiliepe Sousa</creatorcontrib><creatorcontrib>Lorenzón, Esteban Nicolás</creatorcontrib><creatorcontrib>de Aguiar, Andréa Silvia Walter</creatorcontrib><creatorcontrib>Cilli, Eduardo Maffud</creatorcontrib><creatorcontrib>Cavada, Benildo Sousa</creatorcontrib><creatorcontrib>Teixeira, Edson Holanda</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>da Silva, Bruno Rocha</au><au>de Freitas, Victor Aragão Abreu</au><au>Carneiro, Victor Alves</au><au>Arruda, Francisco Vassiliepe Sousa</au><au>Lorenzón, Esteban Nicolás</au><au>de Aguiar, Andréa Silvia Walter</au><au>Cilli, Eduardo Maffud</au><au>Cavada, Benildo Sousa</au><au>Teixeira, Edson Holanda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimicrobial activity of the synthetic peptide Lys-a1 against oral streptococci</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>42</volume><spage>78</spage><epage>83</epage><pages>78-83</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><abstract>► The MIC values ranged from 3.9 to 125μgmL−1, while the MBC values ranged from 3.9 to 500μgmL−1. ► The peptide Lys-a1 demonstrated the potential to inhibit biofilm formation in all bacterial species tested. ► Streptococcus parasanguinis showed the greatest susceptibility to the peptide, reducing the number of viable cells at 1.9μgmL−1. ► The antimicrobial peptide Lys-a1 has shown remarkable antimicrobial and antibiofilm activity.
The peptide LYS-[TRP6]-Hy-A1 (Lys-a1) is a synthetic derivative of the peptide Hy-A1, initially isolated from the frog species Hypsiboas albopunctatus. According to previous research, it is a molecule with broad antimicrobial activity. The objective of this study was to evaluate the antimicrobial activity of the synthetic peptide Lys-a1 (KIFGAIWPLALGALKNLIK-NH2) on the planktonic and biofilm growth of oral bacteria. The methods used to evaluate antimicrobial activity include the following: determination of the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) in microtiter plates for growth in suspension and quantification of biomass by crystal violet staining and counting of colony forming units for biofilm growth. The microorganisms Streptococcus oralis, Streptococcus sanguinis, Streptococcus parasanguinis, Streptococcus salivarius, Streptococcus mutans and Streptococcus sobrinus were grown in Brain Heart Infusion broth at 37°C under atmospheric pressure with 10% CO2. The peptide was solubilized in 0.1% acetic acid (v/v) at various concentrations (500–1.9μgmL−1). Chlorhexidine gluconate 0.12% was used as the positive control, and BHI culture medium was used as the negative control. The tested peptide demonstrated a remarkable antimicrobial effect, inhibiting the planktonic and biofilm growth of all strains tested, even at low concentrations. Thus, the peptide Lys-a1 is an important source for potential antimicrobial agents, especially for the control and prevention of microbial biofilms, which is one of the most important factors in cariogenic processes.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23340019</pmid><doi>10.1016/j.peptides.2012.12.001</doi><tpages>6</tpages></addata></record> |
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| ispartof | Peptides (New York, N.Y. : 1980), 2013-04, Vol.42, p.78-83 |
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| subjects | acetic acid Amino Acid Sequence Amphibian Proteins - chemistry Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology anti-infective properties Antiinfectives and antibacterials Antimicrobial peptide antimicrobials Anura atmospheric pressure Bacteria biofilm Biofilms Biofilms - drug effects Biomass carbon dioxide chlorhexidine Colony Count, Microbial culture media Dental caries Derivatives frogs gentian violet gluconates Hypsiboas Microbial Sensitivity Tests Microorganisms minimum inhibitory concentration Molecular Sequence Data Mouth - microbiology Peptides Peptides - chemistry Peptides - pharmacology solubilization Streptococcus Streptococcus - drug effects Streptococcus mutans Streptococcus mutans - drug effects Streptococcus oralis Streptococcus parasanguinis Streptococcus salivarius Streptococcus sanguinis Streptococcus sanguis - drug effects Streptococcus sobrinus Streptococcus sobrinus - drug effects synthetic peptides |
| title | Antimicrobial activity of the synthetic peptide Lys-a1 against oral streptococci |
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