The relation of leptin and soluble leptin receptor levels with metabolic and clinical parameters in obese and healthy children
•In obese children sLR is lower; leptin and FLI are higher than healthy children.•Insulin resistance is associated with higher serum leptin level and FLI.•FLI is positively correlated with BMI, WC, TC, fasting insulin, and HOMA-IR.•Increased FLI is a compensatory mechanism for increasing peripheral...
Gespeichert in:
| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2014-06, Vol.56, p.72-76 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 76 |
|---|---|
| container_issue | |
| container_start_page | 72 |
| container_title | Peptides (New York, N.Y. : 1980) |
| container_volume | 56 |
| creator | Catli, Gonul Anik, Ahmet Tuhan, Hale Ünver Kume, Tuncay Bober, Ece Abaci, Ayhan |
| description | •In obese children sLR is lower; leptin and FLI are higher than healthy children.•Insulin resistance is associated with higher serum leptin level and FLI.•FLI is positively correlated with BMI, WC, TC, fasting insulin, and HOMA-IR.•Increased FLI is a compensatory mechanism for increasing peripheral leptin effect.•Increased FLI may contribute toward the development of hyperinsulinemia and insulin resistance.
We investigated the relation of serum leptin, soluble leptin receptor (sLR) and free leptin index (FLI) with metabolic and anthropometric parameters in obese and healthy children. Height, weight, waist circumference (WC), fasting serum glucose, insulin, lipid profile, leptin and sLR levels of 35 obese children and 36 healthy children were measured and FLI was calculated as the ratio of leptin to sLR. In obese children, serum leptin and FLI were found significantly higher, while sLR level was significantly lower than the healthy children. Comparison of obese children regarding the insulin resistance showed significantly higher serum leptin and FLI in the insulin resistant group; however sLR level was not different between the insulin resistant and non-resistant obese children. In obese children, sLR was not correlated with any of the metabolic parameters except total cholesterol, while FLI was significantly and positively correlated with BMI, WC, TC, fasting insulin, and HOMA-IR. However, regression analysis confirmed that the HOMA-IR was the only independent variable significantly correlated with FLI in obese children. Findings of this study suggest that in obese children and adolescents (i) serum leptin and FLI were found significantly higher, while sLR level was significantly lower than the healthy children, (ii) increased FLI might be a compensatory mechanism for increasing leptin effect in peripheral tissue, (iii) FLI is a more accurate marker to evaluate leptin resistance than leptin or sLR alone, and (iv) increased FLI may contribute toward the development of hyperinsulinemia and insulin resistance. |
| doi_str_mv | 10.1016/j.peptides.2014.03.015 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1762143759</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0196978114001004</els_id><sourcerecordid>1530951179</sourcerecordid><originalsourceid>FETCH-LOGICAL-c434t-7a3c0c2903e4991a7eb5701b95cb03605ad2242df6eda77b4a643799e09ad1083</originalsourceid><addsrcrecordid>eNqNkc1uGyEUhVHVqnHSvkLEspuZXoY_s2sV9U-K1E26Rgxca7Dw4MI4VTZ99uI47jZZAZfvnLv4CLlm0DNg6uO23-N-iQFrPwATPfAemHxFVmyteSeZMq_JCphRndFrdkEua90CgBBm_ZZcDEIDN0quyN-7CWnB5JaYZ5o3NB1rZ-rmQGtOhzHheVTQt0su7X2PqdI_cZnoDhc35hT9Y8KnOEfvEt274toXlkpbMo9Y8RGY0KVleqB-iikUnN-RNxuXKr5_Oq_Ir69f7m6-d7c_v_24-XzbecHF0mnHPfjBAEdhDHMaR6mBjUb6EbgC6cIwiCFsFAan9SicElwbg2BcYLDmV-TDqXdf8u8D1sXuYvWYkpsxH6plWg2sRaR5HpWSgR6Y0i9AORjJmD62qhPqS6614MbuS9y58mAZ2KNRu7Vno_Zo1AK3zWgLXj_tOIw7DP9jZ4UN-HQCmhO8j1hs9RFnjyE2Y4sNOT634x8rGrZI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1530951179</pqid></control><display><type>article</type><title>The relation of leptin and soluble leptin receptor levels with metabolic and clinical parameters in obese and healthy children</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Catli, Gonul ; Anik, Ahmet ; Tuhan, Hale Ünver ; Kume, Tuncay ; Bober, Ece ; Abaci, Ayhan</creator><creatorcontrib>Catli, Gonul ; Anik, Ahmet ; Tuhan, Hale Ünver ; Kume, Tuncay ; Bober, Ece ; Abaci, Ayhan</creatorcontrib><description>•In obese children sLR is lower; leptin and FLI are higher than healthy children.•Insulin resistance is associated with higher serum leptin level and FLI.•FLI is positively correlated with BMI, WC, TC, fasting insulin, and HOMA-IR.•Increased FLI is a compensatory mechanism for increasing peripheral leptin effect.•Increased FLI may contribute toward the development of hyperinsulinemia and insulin resistance.
We investigated the relation of serum leptin, soluble leptin receptor (sLR) and free leptin index (FLI) with metabolic and anthropometric parameters in obese and healthy children. Height, weight, waist circumference (WC), fasting serum glucose, insulin, lipid profile, leptin and sLR levels of 35 obese children and 36 healthy children were measured and FLI was calculated as the ratio of leptin to sLR. In obese children, serum leptin and FLI were found significantly higher, while sLR level was significantly lower than the healthy children. Comparison of obese children regarding the insulin resistance showed significantly higher serum leptin and FLI in the insulin resistant group; however sLR level was not different between the insulin resistant and non-resistant obese children. In obese children, sLR was not correlated with any of the metabolic parameters except total cholesterol, while FLI was significantly and positively correlated with BMI, WC, TC, fasting insulin, and HOMA-IR. However, regression analysis confirmed that the HOMA-IR was the only independent variable significantly correlated with FLI in obese children. Findings of this study suggest that in obese children and adolescents (i) serum leptin and FLI were found significantly higher, while sLR level was significantly lower than the healthy children, (ii) increased FLI might be a compensatory mechanism for increasing leptin effect in peripheral tissue, (iii) FLI is a more accurate marker to evaluate leptin resistance than leptin or sLR alone, and (iv) increased FLI may contribute toward the development of hyperinsulinemia and insulin resistance.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/j.peptides.2014.03.015</identifier><identifier>PMID: 24703965</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adolescents ; Body Mass Index ; Child ; Childhood ; Children ; Correlation ; Fasting ; Female ; Humans ; Hyperinsulinism - blood ; Insulin ; Insulin - blood ; Insulin resistance ; Insulin Resistance - physiology ; Leptin ; Leptin - blood ; Male ; Obesity ; Obesity - blood ; Peptides ; Receptors ; Receptors, Leptin - blood ; Serums ; Soluble leptin receptor ; Waist Circumference - physiology</subject><ispartof>Peptides (New York, N.Y. : 1980), 2014-06, Vol.56, p.72-76</ispartof><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-7a3c0c2903e4991a7eb5701b95cb03605ad2242df6eda77b4a643799e09ad1083</citedby><cites>FETCH-LOGICAL-c434t-7a3c0c2903e4991a7eb5701b95cb03605ad2242df6eda77b4a643799e09ad1083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.peptides.2014.03.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24703965$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Catli, Gonul</creatorcontrib><creatorcontrib>Anik, Ahmet</creatorcontrib><creatorcontrib>Tuhan, Hale Ünver</creatorcontrib><creatorcontrib>Kume, Tuncay</creatorcontrib><creatorcontrib>Bober, Ece</creatorcontrib><creatorcontrib>Abaci, Ayhan</creatorcontrib><title>The relation of leptin and soluble leptin receptor levels with metabolic and clinical parameters in obese and healthy children</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>•In obese children sLR is lower; leptin and FLI are higher than healthy children.•Insulin resistance is associated with higher serum leptin level and FLI.•FLI is positively correlated with BMI, WC, TC, fasting insulin, and HOMA-IR.•Increased FLI is a compensatory mechanism for increasing peripheral leptin effect.•Increased FLI may contribute toward the development of hyperinsulinemia and insulin resistance.
We investigated the relation of serum leptin, soluble leptin receptor (sLR) and free leptin index (FLI) with metabolic and anthropometric parameters in obese and healthy children. Height, weight, waist circumference (WC), fasting serum glucose, insulin, lipid profile, leptin and sLR levels of 35 obese children and 36 healthy children were measured and FLI was calculated as the ratio of leptin to sLR. In obese children, serum leptin and FLI were found significantly higher, while sLR level was significantly lower than the healthy children. Comparison of obese children regarding the insulin resistance showed significantly higher serum leptin and FLI in the insulin resistant group; however sLR level was not different between the insulin resistant and non-resistant obese children. In obese children, sLR was not correlated with any of the metabolic parameters except total cholesterol, while FLI was significantly and positively correlated with BMI, WC, TC, fasting insulin, and HOMA-IR. However, regression analysis confirmed that the HOMA-IR was the only independent variable significantly correlated with FLI in obese children. Findings of this study suggest that in obese children and adolescents (i) serum leptin and FLI were found significantly higher, while sLR level was significantly lower than the healthy children, (ii) increased FLI might be a compensatory mechanism for increasing leptin effect in peripheral tissue, (iii) FLI is a more accurate marker to evaluate leptin resistance than leptin or sLR alone, and (iv) increased FLI may contribute toward the development of hyperinsulinemia and insulin resistance.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>Body Mass Index</subject><subject>Child</subject><subject>Childhood</subject><subject>Children</subject><subject>Correlation</subject><subject>Fasting</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperinsulinism - blood</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Peptides</subject><subject>Receptors</subject><subject>Receptors, Leptin - blood</subject><subject>Serums</subject><subject>Soluble leptin receptor</subject><subject>Waist Circumference - physiology</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1uGyEUhVHVqnHSvkLEspuZXoY_s2sV9U-K1E26Rgxca7Dw4MI4VTZ99uI47jZZAZfvnLv4CLlm0DNg6uO23-N-iQFrPwATPfAemHxFVmyteSeZMq_JCphRndFrdkEua90CgBBm_ZZcDEIDN0quyN-7CWnB5JaYZ5o3NB1rZ-rmQGtOhzHheVTQt0su7X2PqdI_cZnoDhc35hT9Y8KnOEfvEt274toXlkpbMo9Y8RGY0KVleqB-iikUnN-RNxuXKr5_Oq_Ir69f7m6-d7c_v_24-XzbecHF0mnHPfjBAEdhDHMaR6mBjUb6EbgC6cIwiCFsFAan9SicElwbg2BcYLDmV-TDqXdf8u8D1sXuYvWYkpsxH6plWg2sRaR5HpWSgR6Y0i9AORjJmD62qhPqS6614MbuS9y58mAZ2KNRu7Vno_Zo1AK3zWgLXj_tOIw7DP9jZ4UN-HQCmhO8j1hs9RFnjyE2Y4sNOT634x8rGrZI</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Catli, Gonul</creator><creator>Anik, Ahmet</creator><creator>Tuhan, Hale Ünver</creator><creator>Kume, Tuncay</creator><creator>Bober, Ece</creator><creator>Abaci, Ayhan</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>20140601</creationdate><title>The relation of leptin and soluble leptin receptor levels with metabolic and clinical parameters in obese and healthy children</title><author>Catli, Gonul ; Anik, Ahmet ; Tuhan, Hale Ünver ; Kume, Tuncay ; Bober, Ece ; Abaci, Ayhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-7a3c0c2903e4991a7eb5701b95cb03605ad2242df6eda77b4a643799e09ad1083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>Body Mass Index</topic><topic>Child</topic><topic>Childhood</topic><topic>Children</topic><topic>Correlation</topic><topic>Fasting</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperinsulinism - blood</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Leptin</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Peptides</topic><topic>Receptors</topic><topic>Receptors, Leptin - blood</topic><topic>Serums</topic><topic>Soluble leptin receptor</topic><topic>Waist Circumference - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Catli, Gonul</creatorcontrib><creatorcontrib>Anik, Ahmet</creatorcontrib><creatorcontrib>Tuhan, Hale Ünver</creatorcontrib><creatorcontrib>Kume, Tuncay</creatorcontrib><creatorcontrib>Bober, Ece</creatorcontrib><creatorcontrib>Abaci, Ayhan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Catli, Gonul</au><au>Anik, Ahmet</au><au>Tuhan, Hale Ünver</au><au>Kume, Tuncay</au><au>Bober, Ece</au><au>Abaci, Ayhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relation of leptin and soluble leptin receptor levels with metabolic and clinical parameters in obese and healthy children</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>56</volume><spage>72</spage><epage>76</epage><pages>72-76</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><abstract>•In obese children sLR is lower; leptin and FLI are higher than healthy children.•Insulin resistance is associated with higher serum leptin level and FLI.•FLI is positively correlated with BMI, WC, TC, fasting insulin, and HOMA-IR.•Increased FLI is a compensatory mechanism for increasing peripheral leptin effect.•Increased FLI may contribute toward the development of hyperinsulinemia and insulin resistance.
We investigated the relation of serum leptin, soluble leptin receptor (sLR) and free leptin index (FLI) with metabolic and anthropometric parameters in obese and healthy children. Height, weight, waist circumference (WC), fasting serum glucose, insulin, lipid profile, leptin and sLR levels of 35 obese children and 36 healthy children were measured and FLI was calculated as the ratio of leptin to sLR. In obese children, serum leptin and FLI were found significantly higher, while sLR level was significantly lower than the healthy children. Comparison of obese children regarding the insulin resistance showed significantly higher serum leptin and FLI in the insulin resistant group; however sLR level was not different between the insulin resistant and non-resistant obese children. In obese children, sLR was not correlated with any of the metabolic parameters except total cholesterol, while FLI was significantly and positively correlated with BMI, WC, TC, fasting insulin, and HOMA-IR. However, regression analysis confirmed that the HOMA-IR was the only independent variable significantly correlated with FLI in obese children. Findings of this study suggest that in obese children and adolescents (i) serum leptin and FLI were found significantly higher, while sLR level was significantly lower than the healthy children, (ii) increased FLI might be a compensatory mechanism for increasing leptin effect in peripheral tissue, (iii) FLI is a more accurate marker to evaluate leptin resistance than leptin or sLR alone, and (iv) increased FLI may contribute toward the development of hyperinsulinemia and insulin resistance.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24703965</pmid><doi>10.1016/j.peptides.2014.03.015</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 2014-06, Vol.56, p.72-76 |
| issn | 0196-9781 1873-5169 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1762143759 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Adolescents Body Mass Index Child Childhood Children Correlation Fasting Female Humans Hyperinsulinism - blood Insulin Insulin - blood Insulin resistance Insulin Resistance - physiology Leptin Leptin - blood Male Obesity Obesity - blood Peptides Receptors Receptors, Leptin - blood Serums Soluble leptin receptor Waist Circumference - physiology |
| title | The relation of leptin and soluble leptin receptor levels with metabolic and clinical parameters in obese and healthy children |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T14%3A26%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20relation%20of%20leptin%20and%20soluble%20leptin%20receptor%20levels%20with%20metabolic%20and%20clinical%20parameters%20in%20obese%20and%20healthy%20children&rft.jtitle=Peptides%20(New%20York,%20N.Y.%20:%201980)&rft.au=Catli,%20Gonul&rft.date=2014-06-01&rft.volume=56&rft.spage=72&rft.epage=76&rft.pages=72-76&rft.issn=0196-9781&rft.eissn=1873-5169&rft_id=info:doi/10.1016/j.peptides.2014.03.015&rft_dat=%3Cproquest_cross%3E1530951179%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1530951179&rft_id=info:pmid/24703965&rft_els_id=S0196978114001004&rfr_iscdi=true |