A histological and biomechanical study of bone stress and bone remodeling around immediately loaded implants
Immediate loading（IL） increases the risk of marginal bone loss. The present study investigated the biomechanical response of peri-implant bone in rabbits after IL,aiming at optimizing load management. Ninety-six implants were installed bilaterally into femurs of 48 rabbits. Test implants on the left...
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| Veröffentlicht in: | Science China. Life sciences 2014-06, Vol.57 (6), p.618-626 |
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| creator | Han, JingYun Hou, JianXia Zhou, Gang Wang, Chao Fan, YuBo |
| description | Immediate loading（IL） increases the risk of marginal bone loss. The present study investigated the biomechanical response of peri-implant bone in rabbits after IL,aiming at optimizing load management. Ninety-six implants were installed bilaterally into femurs of 48 rabbits. Test implants on the left side created the maximal initial stress of 6.9 and 13.4 MPa in peri-implant bone and unloaded implants on the contralateral side were controls. Bone morphology and bone-implant interface strength were measured with histological examination and push-out testing during a 12-week observation period. Additionally,the animal data were incorporated into finite element（FE） models to calculate the bone stress distribution at different levels of osseointegration. Results showed that the stress was concentrated in the bone margin and the bone stress gradually decreased as osseointegration proceeded. A stress of about 2.0 MPa in peri-implant bone had a positive effect on new bone formation,osseointegration and bone-implant interface strength. Bone loss was observed in some specimens with stress exceeding 4.0 MPa. Data indicate that IL significantly increases bone stress during the early postoperative period,but the load-bearing capacity of peri-implant bone increases rapidly with an increase of bone-implant contact. Favorable bone responses may be continually promoted when the stress in peri-implant bone is maintained at a definite level. Accordingly,the progressive loading mode is recommended for IL implants. |
| doi_str_mv | 10.1007/s11427-014-4657-7 |
| format | Article |
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The present study investigated the biomechanical response of peri-implant bone in rabbits after IL,aiming at optimizing load management. Ninety-six implants were installed bilaterally into femurs of 48 rabbits. Test implants on the left side created the maximal initial stress of 6.9 and 13.4 MPa in peri-implant bone and unloaded implants on the contralateral side were controls. Bone morphology and bone-implant interface strength were measured with histological examination and push-out testing during a 12-week observation period. Additionally,the animal data were incorporated into finite element（FE） models to calculate the bone stress distribution at different levels of osseointegration. Results showed that the stress was concentrated in the bone margin and the bone stress gradually decreased as osseointegration proceeded. A stress of about 2.0 MPa in peri-implant bone had a positive effect on new bone formation,osseointegration and bone-implant interface strength. Bone loss was observed in some specimens with stress exceeding 4.0 MPa. Data indicate that IL significantly increases bone stress during the early postoperative period,but the load-bearing capacity of peri-implant bone increases rapidly with an increase of bone-implant contact. Favorable bone responses may be continually promoted when the stress in peri-implant bone is maintained at a definite level. Accordingly,the progressive loading mode is recommended for IL implants.</description><identifier>ISSN: 1674-7305</identifier><identifier>EISSN: 1869-1889</identifier><identifier>DOI: 10.1007/s11427-014-4657-7</identifier><identifier>PMID: 24824585</identifier><language>eng</language><publisher>Beijing: Science China Press</publisher><subject>Animals ; Biomechanical Phenomena ; Biomechanics ; Biomedical and Life Sciences ; Bone Remodeling - physiology ; Bone-implant interfaces ; Bones ; Femur - pathology ; Femur - physiology ; Femur - surgery ; Finite Element Analysis ; Finite element method ; Implants ; Implants, Experimental ; Life Sciences ; Male ; Models, Biological ; Osseointegration - physiology ; Postoperative Period ; Rabbits ; Research Paper ; Stress concentration ; Stress, Mechanical ; Stresses ; Time Factors ; Weight-Bearing - physiology ; 加载模式 ; 应力和 ; 生物力学 ; 界面结合强度 ; 白细胞介素 ; 种植体 ; 组织学检查 ; 骨重建</subject><ispartof>Science China. Life sciences, 2014-06, Vol.57 (6), p.618-626</ispartof><rights>The Author(s) 2014</rights><rights>Science in China Press and Springer-Verlag GmbH 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-cfe8787fa882b9bd60ffed35c5b3faeccd6ea4d4bcb32d7387e512d193fa61a23</citedby><cites>FETCH-LOGICAL-c507t-cfe8787fa882b9bd60ffed35c5b3faeccd6ea4d4bcb32d7387e512d193fa61a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/60112X/60112X.jpg</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11427-014-4657-7$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11427-014-4657-7$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24824585$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, JingYun</creatorcontrib><creatorcontrib>Hou, JianXia</creatorcontrib><creatorcontrib>Zhou, Gang</creatorcontrib><creatorcontrib>Wang, Chao</creatorcontrib><creatorcontrib>Fan, YuBo</creatorcontrib><title>A histological and biomechanical study of bone stress and bone remodeling around immediately loaded implants</title><title>Science China. Life sciences</title><addtitle>Sci. China Life Sci</addtitle><addtitle>Sci China Life Sci</addtitle><description>Immediate loading（IL） increases the risk of marginal bone loss. The present study investigated the biomechanical response of peri-implant bone in rabbits after IL,aiming at optimizing load management. Ninety-six implants were installed bilaterally into femurs of 48 rabbits. Test implants on the left side created the maximal initial stress of 6.9 and 13.4 MPa in peri-implant bone and unloaded implants on the contralateral side were controls. Bone morphology and bone-implant interface strength were measured with histological examination and push-out testing during a 12-week observation period. Additionally,the animal data were incorporated into finite element（FE） models to calculate the bone stress distribution at different levels of osseointegration. Results showed that the stress was concentrated in the bone margin and the bone stress gradually decreased as osseointegration proceeded. A stress of about 2.0 MPa in peri-implant bone had a positive effect on new bone formation,osseointegration and bone-implant interface strength. Bone loss was observed in some specimens with stress exceeding 4.0 MPa. Data indicate that IL significantly increases bone stress during the early postoperative period,but the load-bearing capacity of peri-implant bone increases rapidly with an increase of bone-implant contact. Favorable bone responses may be continually promoted when the stress in peri-implant bone is maintained at a definite level. Accordingly,the progressive loading mode is recommended for IL implants.</description><subject>Animals</subject><subject>Biomechanical Phenomena</subject><subject>Biomechanics</subject><subject>Biomedical and Life Sciences</subject><subject>Bone Remodeling - physiology</subject><subject>Bone-implant interfaces</subject><subject>Bones</subject><subject>Femur - pathology</subject><subject>Femur - physiology</subject><subject>Femur - surgery</subject><subject>Finite Element Analysis</subject><subject>Finite element method</subject><subject>Implants</subject><subject>Implants, Experimental</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Models, Biological</subject><subject>Osseointegration - physiology</subject><subject>Postoperative Period</subject><subject>Rabbits</subject><subject>Research Paper</subject><subject>Stress concentration</subject><subject>Stress, Mechanical</subject><subject>Stresses</subject><subject>Time Factors</subject><subject>Weight-Bearing - physiology</subject><subject>加载模式</subject><subject>应力和</subject><subject>生物力学</subject><subject>界面结合强度</subject><subject>白细胞介素</subject><subject>种植体</subject><subject>组织学检查</subject><subject>骨重建</subject><issn>1674-7305</issn><issn>1869-1889</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU1v1DAQhi0EolXpD-CCgrhwCfX4O8eq4kuqxKU9R4492U3lxFs7Oey_xyHbCnFA9cWemWdej_0S8h7oF6BUX2UAwXRNQdRCSV3rV-QcjGpqMKZ5Xc5Ki1pzKs_IZc4PtCzOKdP6LTljwjAhjTwn4braD3mOIe4GZ0NlJ191QxzR7e30J5PnxR-r2FddnLBECXPesDVOOEaPYZh2lU1xKelhHNEPdsZwrEK0HtfUIdhpzu_Im96GjJen_YLcf_t6d_Ojvv31_efN9W3tJNVz7Xo02ujeGsO6pvOK9j16Lp3seG_ROa_QCi8613HmNTcaJTAPTakqsIxfkM-b7iHFxwXz3I5DdhjKEBiX3IJWDATn8AJUCkFBSt28AOWsEVQBLeinf9CHuKSpvHmlwDRUC1Uo2CiXYs4J-_aQhtGmYwu0XT1uN4_b4nG7etzq0vPhpLx05Z-fO54cLQDbgFxK0w7TX1f_R_XjaZJ9nHaPpe9ZWDTGcA2K_wbyS705</recordid><startdate>20140601</startdate><enddate>20140601</enddate><creator>Han, JingYun</creator><creator>Hou, JianXia</creator><creator>Zhou, Gang</creator><creator>Wang, Chao</creator><creator>Fan, YuBo</creator><general>Science China Press</general><general>Springer Nature B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7TB</scope><scope>8FD</scope><scope>FR3</scope></search><sort><creationdate>20140601</creationdate><title>A histological and biomechanical study of bone stress and bone remodeling around immediately loaded implants</title><author>Han, JingYun ; Hou, JianXia ; Zhou, Gang ; Wang, Chao ; Fan, YuBo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-cfe8787fa882b9bd60ffed35c5b3faeccd6ea4d4bcb32d7387e512d193fa61a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Biomechanical Phenomena</topic><topic>Biomechanics</topic><topic>Biomedical and Life Sciences</topic><topic>Bone Remodeling - physiology</topic><topic>Bone-implant interfaces</topic><topic>Bones</topic><topic>Femur - pathology</topic><topic>Femur - physiology</topic><topic>Femur - surgery</topic><topic>Finite Element Analysis</topic><topic>Finite element method</topic><topic>Implants</topic><topic>Implants, Experimental</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Models, Biological</topic><topic>Osseointegration - physiology</topic><topic>Postoperative Period</topic><topic>Rabbits</topic><topic>Research Paper</topic><topic>Stress concentration</topic><topic>Stress, Mechanical</topic><topic>Stresses</topic><topic>Time Factors</topic><topic>Weight-Bearing - physiology</topic><topic>加载模式</topic><topic>应力和</topic><topic>生物力学</topic><topic>界面结合强度</topic><topic>白细胞介素</topic><topic>种植体</topic><topic>组织学检查</topic><topic>骨重建</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, JingYun</creatorcontrib><creatorcontrib>Hou, JianXia</creatorcontrib><creatorcontrib>Zhou, Gang</creatorcontrib><creatorcontrib>Wang, Chao</creatorcontrib><creatorcontrib>Fan, YuBo</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><jtitle>Science China. Life sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, JingYun</au><au>Hou, JianXia</au><au>Zhou, Gang</au><au>Wang, Chao</au><au>Fan, YuBo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A histological and biomechanical study of bone stress and bone remodeling around immediately loaded implants</atitle><jtitle>Science China. Life sciences</jtitle><stitle>Sci. China Life Sci</stitle><addtitle>Sci China Life Sci</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>57</volume><issue>6</issue><spage>618</spage><epage>626</epage><pages>618-626</pages><issn>1674-7305</issn><eissn>1869-1889</eissn><abstract>Immediate loading（IL） increases the risk of marginal bone loss. The present study investigated the biomechanical response of peri-implant bone in rabbits after IL,aiming at optimizing load management. Ninety-six implants were installed bilaterally into femurs of 48 rabbits. Test implants on the left side created the maximal initial stress of 6.9 and 13.4 MPa in peri-implant bone and unloaded implants on the contralateral side were controls. Bone morphology and bone-implant interface strength were measured with histological examination and push-out testing during a 12-week observation period. Additionally,the animal data were incorporated into finite element（FE） models to calculate the bone stress distribution at different levels of osseointegration. Results showed that the stress was concentrated in the bone margin and the bone stress gradually decreased as osseointegration proceeded. A stress of about 2.0 MPa in peri-implant bone had a positive effect on new bone formation,osseointegration and bone-implant interface strength. Bone loss was observed in some specimens with stress exceeding 4.0 MPa. Data indicate that IL significantly increases bone stress during the early postoperative period,but the load-bearing capacity of peri-implant bone increases rapidly with an increase of bone-implant contact. Favorable bone responses may be continually promoted when the stress in peri-implant bone is maintained at a definite level. Accordingly,the progressive loading mode is recommended for IL implants.</abstract><cop>Beijing</cop><pub>Science China Press</pub><pmid>24824585</pmid><doi>10.1007/s11427-014-4657-7</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biomechanical Phenomena Biomechanics Biomedical and Life Sciences Bone Remodeling - physiology Bone-implant interfaces Bones Femur - pathology Femur - physiology Femur - surgery Finite Element Analysis Finite element method Implants Implants, Experimental Life Sciences Male Models, Biological Osseointegration - physiology Postoperative Period Rabbits Research Paper Stress concentration Stress, Mechanical Stresses Time Factors Weight-Bearing - physiology 加载模式 应力和 生物力学 界面结合强度 白细胞介素 种植体 组织学检查 骨重建 |
| title | A histological and biomechanical study of bone stress and bone remodeling around immediately loaded implants |
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