Adiponectin inhibits leptin-induced oncogenic signalling in oesophageal cancer cells by activation of PTP1B

•Leptin stimulated oncogenic behaviour in oesophageal adenocarcinoma cells.•Adiponectin inhibited leptin-induced signal transduction and oncogenic behaviour.•Adiponectin independently increased PTP1B activity and PTP1B protein expression.•Inhibition of leptin-signal transduction by adiponectin was P...

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Veröffentlicht in:	Molecular and cellular endocrinology 2014-01, Vol.382 (1), p.150-158
Hauptverfasser:	Beales, Ian L.P., Garcia-Morales, Carla, Ogunwobi, Olorunseun O., Mutungi, Gabriel
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Activation Adiponectin Adiponectin - pharmacology Apoptosis - drug effects Barrett’s oesophagus Cancer Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Enzyme Activation - drug effects Esophageal Neoplasms - enzymology Esophageal Neoplasms - pathology Humans Inhibitors Janus Kinase 2 - metabolism Leptin Leptin - pharmacology Matrix Metalloproteinases - secretion Migration Models, Biological Neoplasm Invasiveness Obesity Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism PTP1N Secretions Signal Transduction - drug effects Signalling STAT3 STAT3 Transcription Factor - metabolism
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