The anti-inflammatory and anti-apoptotic effects of nesfatin-1 in the traumatic rat brain

► Nesfatin-1 may inhibit nuclear factor kappa-B-dependent inflammatory responses after traumatic brain injury in rats. ► Nesfatin-1 may lessen caspase-3-mediated neuronal cell apoptosis after traumatic brain injury in rats. ► Nesfatin-1 may ameliorate the inflammation and furthermore reduce neuronal...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2012-07, Vol.36 (1), p.39-45
Hauptverfasser:	Tang, Chong-Hui, Fu, Xiao-Jun, Xu, Xin-Long, Wei, Xiao-Jie, Pan, Hong-Song
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Brain Brain Injuries - drug therapy Brain Injuries - metabolism Brain Injuries - pathology Calcium-Binding Proteins - administration & dosage Calcium-Binding Proteins - physiology Caspase 3 - metabolism caspase-3 cells Cytokines - metabolism DNA-Binding Proteins - administration & dosage DNA-Binding Proteins - physiology Gene Expression genes head hemorrhage Hemorrhages Inflammation Inflammation Mediators - administration & dosage Inflammation Mediators - physiology Injections, Intraperitoneal Injuries Injury prevention interleukin-1beta interleukin-6 interleukins Male Nerve Tissue Proteins - administration & dosage Nerve Tissue Proteins - physiology Nesfatin-1 Neuronal cell apoptosis neurons Neurons - physiology NF-kappa B - genetics NF-kappa B - metabolism Rats Rats, Wistar tissues Traumatic brain injury tumor necrosis factor-alpha Tumors
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