Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA interference

Specific mRNA degradation mediated by double-stranded RNA (dsRNA), which is termed RNA interference (RNAi), is a useful tool with which to study gene function in several systems. We report here that in mouse oocytes, RNAi provides a suitable and robust approach to study the function of dormant mater...

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Veröffentlicht in:	Development (Cambridge) 2000-10, Vol.127 (19), p.4147-4156
Hauptverfasser:	Svoboda, P, Stein, P, Hayashi, H, Schultz, R M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CDC2 Protein Kinase - metabolism Cyclin B - metabolism Mice Mitogen-Activated Protein Kinases - metabolism Mos gene Oocytes - metabolism Oogenesis Plat gene Protein Biosynthesis - drug effects Proto-Oncogene Proteins c-mos - genetics RNA, Double-Stranded - pharmacology RNA, Messenger, Stored - metabolism Tissue Plasminogen Activator - biosynthesis Tissue Plasminogen Activator - genetics
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