Resolution of Stepwise Cooperativities of Copper Binding by the Homotetrameric Copper-Sensitive Operon Repressor (CsoR): Impact on Structure and Stability

The cooperativity of ligand binding is central to biological regulation and new approaches are needed to quantify these allosteric relationships. Herein, we exploit a suite of mass spectrometry (MS) experiments to provide novel insights into homotropic Cu‐binding cooperativity, gas‐phase stabilities...

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Veröffentlicht in:	Angewandte Chemie 2015-10, Vol.127 (43), p.12986-12990
Hauptverfasser:	Jacobs, Alexander D., Chang, Feng-Ming James, Morrison, Lindsay, Dilger, Jonathan M., Wysocki, Vicki H., Clemmer, David E., Giedroc, David P.
Format:	Artikel
Sprache:	eng ; ger
Schlagworte:	Allosterie Binding Biological Chemistry Control Copper Formations Kupfer Ligands Mass spectrometry Metalloproteine Metalloregulation Oberflächeninduzierte Dissoziation Stability
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