Environmentally Relevant Concentrations of Atrazine and Ametrine Induce Micronuclei Formation and Nuclear Abnormalities in Erythrocytes of Fish
A rapid and sensitive method using liquid chromatography coupled with mass spectrometry triple quadrupole direct aqueous injection for analysis of atrazine and ametrine herbicides in surface waters was developed. According to the validation method, water samples from six different locations in the P...
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| Veröffentlicht in: | Archives of environmental contamination and toxicology 2015-11, Vol.69 (4), p.577-585 |
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| creator | Botelho, R. G. Monteiro, S. H. Christofoletti, C. A. Moura-Andrade, G. C. R. Tornisielo, V. L. |
| description | A rapid and sensitive method using liquid chromatography coupled with mass spectrometry triple quadrupole direct aqueous injection for analysis of atrazine and ametrine herbicides in surface waters was developed. According to the validation method, water samples from six different locations in the Piracicaba River were collected monthly from February 2011 to January 2012 and injected into a liquid chromatographer/dual mass spectrometer without the need for sample extraction. The method was validated and shown to be precise and accurate; limits of detection and quantification were 0.07 and 0.10 µg L
−1
for atrazine and 0.09 and 0.14 µg L
−1
for ametrine. During the sampling period, concentrations of atrazine ranged from 0.11 to 1.92 µg L
−1
and ametrine from 0.25 to 1.44 µg L
−1
. After analysis of the herbicides,
Danio rerio
were exposed a range of concentrations found in the river water to check the induction of micronuclei and nuclear abnormalities (NAs) in erythrocytes. Concentrations of atrazine and ametrine >1.0 and 1.5 µg L
−1
, respectively, induced MN formation in
D. rerio
. Ametrine was shown to be more genotoxic to
D. rerio
because a greater incidence of NAs was observed compared with atrazine. Therefore, environmentally relevant concentrations of atrazine and ametrine found in the Piracicaba River are dangerous to the aquatic biota. |
| doi_str_mv | 10.1007/s00244-015-0171-6 |
| format | Article |
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−1
for atrazine and 0.09 and 0.14 µg L
−1
for ametrine. During the sampling period, concentrations of atrazine ranged from 0.11 to 1.92 µg L
−1
and ametrine from 0.25 to 1.44 µg L
−1
. After analysis of the herbicides,
Danio rerio
were exposed a range of concentrations found in the river water to check the induction of micronuclei and nuclear abnormalities (NAs) in erythrocytes. Concentrations of atrazine and ametrine >1.0 and 1.5 µg L
−1
, respectively, induced MN formation in
D. rerio
. Ametrine was shown to be more genotoxic to
D. rerio
because a greater incidence of NAs was observed compared with atrazine. Therefore, environmentally relevant concentrations of atrazine and ametrine found in the Piracicaba River are dangerous to the aquatic biota.</description><identifier>ISSN: 0090-4341</identifier><identifier>EISSN: 1432-0703</identifier><identifier>DOI: 10.1007/s00244-015-0171-6</identifier><identifier>PMID: 26081367</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Abnormalities ; Analysis ; Animals ; Aquatic animals ; Atrazine ; Atrazine - analysis ; Atrazine - toxicity ; Biota ; Brazil ; Cellulose acetate ; Chemical contaminants ; Chromatography ; Chromosomes ; Danio rerio ; DNA Damage ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental Monitoring ; Erythrocytes ; Erythrocytes - drug effects ; Fish ; Formations ; Freshwater ; Herbicides ; Herbicides - analysis ; Herbicides - toxicity ; Liquid chromatography ; Mass spectrometry ; Micronuclei, Chromosome-Defective ; Minerals - analysis ; Minerals - toxicity ; Monitoring/Environmental Analysis ; Mutagens - toxicity ; Pollution ; Rivers ; Scientific imaging ; Soil Science & Conservation ; Studies ; Sugarcane ; Surface water ; Test methods ; Water analysis ; Water Pollutants, Chemical - analysis ; Water Pollutants, Chemical - toxicity ; Water pollution ; Water sampling ; Zebrafish</subject><ispartof>Archives of environmental contamination and toxicology, 2015-11, Vol.69 (4), p.577-585</ispartof><rights>Springer Science+Business Media New York 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c578t-6e6180f63dc23ce335e325698b1c07e3de402822e359520b38d565e877df4e1e3</citedby><cites>FETCH-LOGICAL-c578t-6e6180f63dc23ce335e325698b1c07e3de402822e359520b38d565e877df4e1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00244-015-0171-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00244-015-0171-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26081367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Botelho, R. G.</creatorcontrib><creatorcontrib>Monteiro, S. H.</creatorcontrib><creatorcontrib>Christofoletti, C. A.</creatorcontrib><creatorcontrib>Moura-Andrade, G. C. R.</creatorcontrib><creatorcontrib>Tornisielo, V. L.</creatorcontrib><title>Environmentally Relevant Concentrations of Atrazine and Ametrine Induce Micronuclei Formation and Nuclear Abnormalities in Erythrocytes of Fish</title><title>Archives of environmental contamination and toxicology</title><addtitle>Arch Environ Contam Toxicol</addtitle><addtitle>Arch Environ Contam Toxicol</addtitle><description>A rapid and sensitive method using liquid chromatography coupled with mass spectrometry triple quadrupole direct aqueous injection for analysis of atrazine and ametrine herbicides in surface waters was developed. According to the validation method, water samples from six different locations in the Piracicaba River were collected monthly from February 2011 to January 2012 and injected into a liquid chromatographer/dual mass spectrometer without the need for sample extraction. The method was validated and shown to be precise and accurate; limits of detection and quantification were 0.07 and 0.10 µg L
−1
for atrazine and 0.09 and 0.14 µg L
−1
for ametrine. During the sampling period, concentrations of atrazine ranged from 0.11 to 1.92 µg L
−1
and ametrine from 0.25 to 1.44 µg L
−1
. After analysis of the herbicides,
Danio rerio
were exposed a range of concentrations found in the river water to check the induction of micronuclei and nuclear abnormalities (NAs) in erythrocytes. Concentrations of atrazine and ametrine >1.0 and 1.5 µg L
−1
, respectively, induced MN formation in
D. rerio
. Ametrine was shown to be more genotoxic to
D. rerio
because a greater incidence of NAs was observed compared with atrazine. Therefore, environmentally relevant concentrations of atrazine and ametrine found in the Piracicaba River are dangerous to the aquatic biota.</description><subject>Abnormalities</subject><subject>Analysis</subject><subject>Animals</subject><subject>Aquatic animals</subject><subject>Atrazine</subject><subject>Atrazine - analysis</subject><subject>Atrazine - toxicity</subject><subject>Biota</subject><subject>Brazil</subject><subject>Cellulose acetate</subject><subject>Chemical contaminants</subject><subject>Chromatography</subject><subject>Chromosomes</subject><subject>Danio rerio</subject><subject>DNA Damage</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental Monitoring</subject><subject>Erythrocytes</subject><subject>Erythrocytes - drug effects</subject><subject>Fish</subject><subject>Formations</subject><subject>Freshwater</subject><subject>Herbicides</subject><subject>Herbicides - analysis</subject><subject>Herbicides - toxicity</subject><subject>Liquid chromatography</subject><subject>Mass spectrometry</subject><subject>Micronuclei, Chromosome-Defective</subject><subject>Minerals - analysis</subject><subject>Minerals - toxicity</subject><subject>Monitoring/Environmental Analysis</subject><subject>Mutagens - toxicity</subject><subject>Pollution</subject><subject>Rivers</subject><subject>Scientific imaging</subject><subject>Soil Science & Conservation</subject><subject>Studies</subject><subject>Sugarcane</subject><subject>Surface water</subject><subject>Test methods</subject><subject>Water analysis</subject><subject>Water Pollutants, Chemical - analysis</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>Water pollution</subject><subject>Water sampling</subject><subject>Zebrafish</subject><issn>0090-4341</issn><issn>1432-0703</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkdFqFDEUhoNY7Lb6AN5IwBtvxp6TzCTZy2XZtYVaQfQ6zGbO2JSZTE1mCutL-MpmdquIUPAihPPnO_9J8jP2GuE9AuiLBCDKsgCs8tJYqGdsgaUUBWiQz9kCYAlFKUs8ZWcp3QGgMKZ8wU6FAoNS6QX7uQkPPg6hpzDWXbfnn6mjhzqMfD0El8VYj34IiQ8tX-Xihw_E69DwVU9jnIur0EyO-Efvss3kOvJ8O8T-0HYgb2axjny1C7Pe-dFT4j7wTdyPt3Fw-5EO_lufbl-yk7buEr163M_Z1-3my_qyuP704Wq9ui5cpc1YKFJooFWycUI6krIiKSq1NDt0oEk2VIIwQpCslpWAnTRNpSoyWjdtSUjynL07-t7H4ftEabS9T466rg40TMmiVgKWKIT6D1RoZbREndG3_6B3wxRDfshMIWpACZnCI5V_LKVIrb2Pvq_j3iLYOVh7DNbmYO0crJ0v8ebRedr11Pzp-J1kBsQRSPkofKP41-gnXX8B-yKueg</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Botelho, R. G.</creator><creator>Monteiro, S. H.</creator><creator>Christofoletti, C. A.</creator><creator>Moura-Andrade, G. C. R.</creator><creator>Tornisielo, V. 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G. ; Monteiro, S. H. ; Christofoletti, C. A. ; Moura-Andrade, G. C. R. ; Tornisielo, V. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c578t-6e6180f63dc23ce335e325698b1c07e3de402822e359520b38d565e877df4e1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Abnormalities</topic><topic>Analysis</topic><topic>Animals</topic><topic>Aquatic animals</topic><topic>Atrazine</topic><topic>Atrazine - analysis</topic><topic>Atrazine - toxicity</topic><topic>Biota</topic><topic>Brazil</topic><topic>Cellulose acetate</topic><topic>Chemical contaminants</topic><topic>Chromatography</topic><topic>Chromosomes</topic><topic>Danio rerio</topic><topic>DNA Damage</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Environmental Monitoring</topic><topic>Erythrocytes</topic><topic>Erythrocytes - drug effects</topic><topic>Fish</topic><topic>Formations</topic><topic>Freshwater</topic><topic>Herbicides</topic><topic>Herbicides - analysis</topic><topic>Herbicides - toxicity</topic><topic>Liquid chromatography</topic><topic>Mass spectrometry</topic><topic>Micronuclei, Chromosome-Defective</topic><topic>Minerals - analysis</topic><topic>Minerals - toxicity</topic><topic>Monitoring/Environmental Analysis</topic><topic>Mutagens - toxicity</topic><topic>Pollution</topic><topic>Rivers</topic><topic>Scientific imaging</topic><topic>Soil Science & Conservation</topic><topic>Studies</topic><topic>Sugarcane</topic><topic>Surface water</topic><topic>Test methods</topic><topic>Water analysis</topic><topic>Water Pollutants, Chemical - analysis</topic><topic>Water Pollutants, Chemical - toxicity</topic><topic>Water pollution</topic><topic>Water sampling</topic><topic>Zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Botelho, R. 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G.</au><au>Monteiro, S. H.</au><au>Christofoletti, C. A.</au><au>Moura-Andrade, G. C. R.</au><au>Tornisielo, V. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmentally Relevant Concentrations of Atrazine and Ametrine Induce Micronuclei Formation and Nuclear Abnormalities in Erythrocytes of Fish</atitle><jtitle>Archives of environmental contamination and toxicology</jtitle><stitle>Arch Environ Contam Toxicol</stitle><addtitle>Arch Environ Contam Toxicol</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>69</volume><issue>4</issue><spage>577</spage><epage>585</epage><pages>577-585</pages><issn>0090-4341</issn><eissn>1432-0703</eissn><abstract>A rapid and sensitive method using liquid chromatography coupled with mass spectrometry triple quadrupole direct aqueous injection for analysis of atrazine and ametrine herbicides in surface waters was developed. According to the validation method, water samples from six different locations in the Piracicaba River were collected monthly from February 2011 to January 2012 and injected into a liquid chromatographer/dual mass spectrometer without the need for sample extraction. The method was validated and shown to be precise and accurate; limits of detection and quantification were 0.07 and 0.10 µg L
−1
for atrazine and 0.09 and 0.14 µg L
−1
for ametrine. During the sampling period, concentrations of atrazine ranged from 0.11 to 1.92 µg L
−1
and ametrine from 0.25 to 1.44 µg L
−1
. After analysis of the herbicides,
Danio rerio
were exposed a range of concentrations found in the river water to check the induction of micronuclei and nuclear abnormalities (NAs) in erythrocytes. Concentrations of atrazine and ametrine >1.0 and 1.5 µg L
−1
, respectively, induced MN formation in
D. rerio
. Ametrine was shown to be more genotoxic to
D. rerio
because a greater incidence of NAs was observed compared with atrazine. Therefore, environmentally relevant concentrations of atrazine and ametrine found in the Piracicaba River are dangerous to the aquatic biota.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26081367</pmid><doi>10.1007/s00244-015-0171-6</doi><tpages>9</tpages></addata></record> |
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| ispartof | Archives of environmental contamination and toxicology, 2015-11, Vol.69 (4), p.577-585 |
| issn | 0090-4341 1432-0703 |
| language | eng |
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| source | MEDLINE; Springer Online Journals Complete |
| subjects | Abnormalities Analysis Animals Aquatic animals Atrazine Atrazine - analysis Atrazine - toxicity Biota Brazil Cellulose acetate Chemical contaminants Chromatography Chromosomes Danio rerio DNA Damage Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental Monitoring Erythrocytes Erythrocytes - drug effects Fish Formations Freshwater Herbicides Herbicides - analysis Herbicides - toxicity Liquid chromatography Mass spectrometry Micronuclei, Chromosome-Defective Minerals - analysis Minerals - toxicity Monitoring/Environmental Analysis Mutagens - toxicity Pollution Rivers Scientific imaging Soil Science & Conservation Studies Sugarcane Surface water Test methods Water analysis Water Pollutants, Chemical - analysis Water Pollutants, Chemical - toxicity Water pollution Water sampling Zebrafish |
| title | Environmentally Relevant Concentrations of Atrazine and Ametrine Induce Micronuclei Formation and Nuclear Abnormalities in Erythrocytes of Fish |
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