Structure and Biomedical Applications of Amyloid Oligomer Nanoparticles

Amyloid oligomers are nonfibrillar polypeptide aggregates linked to diseases, such as Alzheimer’s and Parkinson’s. Here we show that these aggregates possess a compact, quasi-crystalline architecture that presents significant nanoscale regularity. The amyloid oligomers are dynamic assemblies and are...

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Veröffentlicht in:	ACS nano 2014-11, Vol.8 (11), p.11042-11052
Hauptverfasser:	Kumar, Senthil T, Meinhardt, Jessica, Fuchs, Ann-Kathrin, Aumüller, Tobias, Leppert, Jörg, Büchele, Berthold, Knüpfer, Uwe, Ramachandran, Ramadurai, Yadav, Jay Kant, Prell, Erik, Morgado, Isabel, Ohlenschläger, Oliver, Horn, Uwe, Simmet, Thomas, Görlach, Matthias, Fändrich, Marcus
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Amyloid - chemistry Assemblies Biopolymers - chemistry Delivery systems Diseases Drug delivery systems Microscopy, Electron, Transmission Nanoparticles Nanostructure Nuclear Magnetic Resonance, Biomolecular Oligomers Protein Conformation
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