Base-Pairing Energies of Protonated Nucleobase Pairs and Proton Affinities of 1‑Methylated Cytosines: Model Systems for the Effects of the Sugar Moiety on the Stability of DNA i‑Motif Conformations

Expansion of (CCG) n ·(CGG) n trinucleotide repeats leads to hypermethylation of cytosine residues and results in Fragile X syndrome, the most common cause of inherited intellectual disability in humans. The (CCG) n ·(CGG) n repeats adopt i-motif conformations that are preferentially stabilized by b...

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