Using Temperature-Sensitive Smart Polymers to Regulate DNA-Mediated Nanoassembly and Encoded Nanocarrier Drug Release

In this paper we describe the use of a temperature-responsive polymer to regulate DNA interactions in both a DNA-mediated assembly system and a DNA-encoded drug delivery system. A thermoresponsive pNIPAAm-co-pAAm polymer, with a transition temperature (T C) of 51 °C, was synthesized with thiol modif...

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Veröffentlicht in:	ACS nano 2013-08, Vol.7 (8), p.7011-7020
Hauptverfasser:	Hamner, Kristen L, Alexander, Colleen M, Coopersmith, Kaitlin, Reishofer, David, Provenza, Christina, Maye, Mathew M
Format:	Artikel
Sprache:	eng
Schlagworte:	Accessibility Cell Line, Tumor Chemotherapy Deoxyribonucleic acid DNA - chemistry DNA, Single-Stranded - chemistry Doxorubicin Doxorubicin - administration & dosage Drug Carriers - chemistry Drug delivery systems Drugs Gold Gold - chemistry Humans Metal Nanoparticles - chemistry Micelles Nanoparticles - chemistry Nanostructure Nucleic Acid Hybridization Polymers Polymers - chemistry Temperature Time Factors Ultraviolet Rays
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