Photothermally Triggered Cytosolic Drug Delivery via Endosome Disruption Using a Functionalized Reduced Graphene Oxide

Graphene oxide has unique physiochemical properties, showing great potential in biomedical applications. In the present work, functionalized reduced graphene oxide (PEG-BPEI-rGO) has been developed as a nanotemplate for photothermally triggered cytosolic drug delivery by inducing endosomal disruptio...

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Veröffentlicht in:	ACS nano 2013-08, Vol.7 (8), p.6735-6746
Hauptverfasser:	Kim, Hyunwoo, Lee, Duhwan, Kim, Jinhwan, Kim, Tae-il, Kim, Won Jong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Cell Line, Tumor Cellular Cytosol - metabolism Disruption Doxorubicin - administration & dosage Drug Carriers - chemistry Drug delivery systems Endosomes Endosomes - metabolism Glutathione - chemistry Glutathione - metabolism Graphene Graphite - chemistry HeLa Cells Humans Infrared Rays Irradiation Microscopy, Confocal Nanostructure Nanotechnology - methods Neoplasms - drug therapy Neoplasms - metabolism Oxides Oxides - chemistry Photochemistry - methods Polyethylene Glycols - chemistry Polyethyleneimine - analogs & derivatives Polyethyleneimine - chemistry Spectroscopy, Near-Infrared Sponges Time Factors
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