Cell-Imprinted Substrates Direct the Fate of Stem Cells

Smart nanoenvironments were obtained by cell-imprinted substrates based on mature and dedifferentiated chondrocytes as templates. Rabbit adipose derived mesenchymal stem cells (ADSCs) seeded on these cell-imprinted substrates were driven to adopt the specific shape (as determined in terms of cell mo...

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Veröffentlicht in:	ACS nano 2013-10, Vol.7 (10), p.8379-8384
Hauptverfasser:	Mahmoudi, Morteza, Bonakdar, Shahin, Shokrgozar, Mohammad A, Aghaverdi, Haniyeh, Hartmann, Raimo, Pick, André, Witte, Gregor, Parak, Wolfgang J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - cytology Animals Cell Differentiation Cell Lineage Cellular Differentiation Fragments Gene expression Gene Expression Profiling Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Morphology Nanostructure Rabbits Stem cells Topography
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creator	Mahmoudi, Morteza Bonakdar, Shahin Shokrgozar, Mohammad A Aghaverdi, Haniyeh Hartmann, Raimo Pick, André Witte, Gregor Parak, Wolfgang J
description	Smart nanoenvironments were obtained by cell-imprinted substrates based on mature and dedifferentiated chondrocytes as templates. Rabbit adipose derived mesenchymal stem cells (ADSCs) seeded on these cell-imprinted substrates were driven to adopt the specific shape (as determined in terms of cell morphology) and molecular characteristics (as determined in terms of gene expression) of the cell types which had been used as template for the cell-imprinting. This method might pave the way for a reliable, efficient, and cheap way of controlling stem cell differentiation. Data also suggest that besides residual cellular fragments, which are presented on the template surface, the imprinted topography of the templates plays a role in the differentiation of the stem cells.
doi_str_mv	10.1021/nn403844q
format	Article
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subjects	Adipose Tissue - cytology Animals Cell Differentiation Cell Lineage Cellular Differentiation Fragments Gene expression Gene Expression Profiling Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Morphology Nanostructure Rabbits Stem cells Topography
title	Cell-Imprinted Substrates Direct the Fate of Stem Cells
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