Proteomic identification of salivary biomarkers in 20 patients with Oral Squamous Cell Carcinoma
The aim of this study is to assess the proteomic salivary profile using SELDI-TOF-MS technology in patients with Oral Squamous Cell Carcinoma (OSCC), grouped in relation to the TNM staging and compared with healthy subjects. In this secondary hospital based case-control study, patients with confirme...
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| Veröffentlicht in: | Annali di stomatologia 2014-04, Vol.5 (2), p.12-12 |
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| creator | Termine, N Panzarella, V Lo Muzio, L Campisi, G |
| description | The aim of this study is to assess the proteomic salivary profile using SELDI-TOF-MS technology in patients with Oral Squamous Cell Carcinoma (OSCC), grouped in relation to the TNM staging and compared with healthy subjects. In this secondary hospital based case-control study, patients with confirmed histopathological diagnosis of primary untreated OSCC as "cases" and healthy age- and sex-matched subjects as "controls" were consecutively enrolled, after informed consent. Saliva was collected by spitting directly into a clean 15 mL conical tube, aliquoted and stored at -80 degrees Celsius until use. SELDI-TOF Q10 ProteinChip system was used to screen for differentially expressed proteins in the saliva samples according to the manufacturer's instructions. Univariate statistics and Roc plot were used for data analysis. Twenty cases and 20 controls were included. In cases, seven were early-EsOSCC and 13 were late-LsOSCC. Proteomic analysis showed significant statistical differences in peptide profile in control vs OSCC and in EsOSCC vs LsOSCC samples. |
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In this secondary hospital based case-control study, patients with confirmed histopathological diagnosis of primary untreated OSCC as "cases" and healthy age- and sex-matched subjects as "controls" were consecutively enrolled, after informed consent. Saliva was collected by spitting directly into a clean 15 mL conical tube, aliquoted and stored at -80 degrees Celsius until use. SELDI-TOF Q10 ProteinChip system was used to screen for differentially expressed proteins in the saliva samples according to the manufacturer's instructions. Univariate statistics and Roc plot were used for data analysis. Twenty cases and 20 controls were included. In cases, seven were early-EsOSCC and 13 were late-LsOSCC. 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| language | eng |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Biomarkers Hospitals Medical research Middle age Patients Peptides Proteomics Saliva Samples Statistical analysis Statistical methods Statistics |
| title | Proteomic identification of salivary biomarkers in 20 patients with Oral Squamous Cell Carcinoma |
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