Softer Zwitterionic Nanogels for Longer Circulation and Lower Splenic Accumulation

Zwitterionic nanogels of varying stiffness were prepared by tuning their cross-linking densities and reactant contents. In vivo studies of these nanogels show that softer nanogels pass through physiological barriers, especially the splenic filtration, more easily than their stiffer counterparts, con...

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Veröffentlicht in:ACS nano 2012-08, Vol.6 (8), p.6681-6686
Hauptverfasser: Zhang, Lei, Cao, Zhiqiang, Li, Yuting, Ella-Menye, Jean-Rene, Bai, Tao, Jiang, Shaoyi
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Sprache:eng
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