Complement-fixing antibodies against denatured HLA and MICA antigens are associated with antibody mediated rejection

We have found antibodies against denatured HLA class I antigens in the serum of allograft recipients which were not significantly associated with graft failure. It is unknown whether transplant recipients also have denatured HLA class II and MICA antibodies. The effects of denatured HLA class I, cla...

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Veröffentlicht in:	Experimental and molecular pathology 2016-02, Vol.100 (1), p.45-50
Hauptverfasser:	Cai, Junchao, Terasaki, Paul I., Zhu, Dong, Lachmann, Nils, Schönemann, Constanze, Everly, Matthew J., Qing, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibodies - immunology Antibody epitope Antibody-mediated rejection c1q-fixing antibody Complement C1q - immunology Denatured antigen Female Graft Rejection - immunology Graft Survival - immunology Histocompatibility Antigens Class I - immunology HLA antibody HLA Antigens - immunology Humans Kidney Transplantation Male MICA antibody Middle Aged Renal transplant Retrospective Studies Transplantation, Homologous - methods
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