Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37

Vitamin D has immunomodulatory properties in the defence against pathogens. Its insufficiency is a widespread feature of cystic fibrosis (CF) patients, which are repeatedly suffering from rhinovirus (RV)-induced pulmonary exacerbations.To investigate whether vitamin D has antiviral activity, primary...

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Veröffentlicht in:	The European respiratory journal 2016-02, Vol.47 (2), p.520-530
Hauptverfasser:	Schögler, Aline, Muster, Ricardo J, Kieninger, Elisabeth, Casaulta, Carmen, Tapparel, Caroline, Jung, Andreas, Moeller, Alexander, Geiser, Thomas, Regamey, Nicolas, Alves, Marco P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antimicrobial Cationic Peptides Bronchi - cytology Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - virology Case-Control Studies Cathelicidins - drug effects Cathelicidins - metabolism Child Child, Preschool Cholecalciferol - pharmacology Cystic Fibrosis - metabolism Cystic Fibrosis - virology Epithelial Cells - drug effects Epithelial Cells - virology Female Humans Infant Male Real-Time Polymerase Chain Reaction Rhinovirus - drug effects Viral Load Virus Replication - drug effects Vitamin D - pharmacology Vitamins - pharmacology
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