Effects of spironolactone towards rabbit atrial remodeling with rapid pacing
This study aimed to observe the effects of spironolactone towards the rabbit atrial remodeling with rapid atrial pacing (RAP). 30 rabbits were randomly divided into control group, RAP group and spironolactone group, with 10 rabbits in each group. RAP was performed at the speed of 800 beats/min for 8...
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| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2016-01, Vol.29 (1), p.151-156 |
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| creator | Wang, Lian-Fa Gu, Lei Huang, Meng-Xun Zhou, Wen-Bing Li, Hua Zhang, Bang-Zhu |
| description | This study aimed to observe the effects of spironolactone towards the rabbit atrial remodeling with rapid atrial pacing (RAP). 30 rabbits were randomly divided into control group, RAP group and spironolactone group, with 10 rabbits in each group. RAP was performed at the speed of 800 beats/min for 8 h, atrial effective refractory period (AERP) was determined before and at the 1(st), 2(nd), 4(th), 6(th) and 8(th) of the pacing, the expressions of atrial muscular calcium channel α1C subunit and β1 subunit mRNA were performed the RT-PCR detection, and ultrastructural changes of atrial myocytes were observed. AERP of RAP group shortened, with poor frequency adaptability; the expressions of calcium channel α1C subunit and β1 subunit mRNA decreased 22% and 26%, respectively, when compared with the control group; ultrastructure of atrial myocytes changed significantly. AERP of spironotlactone group shortened less that RAP group, and the frequency adaptability was maintained, the decreased expressions of calcium channel α1C subunit and β1 subunit mRNA significantly reduced. RAP could cause atrial remodeling, while spironolactone could inhibit RAP-induced atrial remodeling. |
| format | Article |
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RAP was performed at the speed of 800 beats/min for 8 h, atrial effective refractory period (AERP) was determined before and at the 1(st), 2(nd), 4(th), 6(th) and 8(th) of the pacing, the expressions of atrial muscular calcium channel α1C subunit and β1 subunit mRNA were performed the RT-PCR detection, and ultrastructural changes of atrial myocytes were observed. AERP of RAP group shortened, with poor frequency adaptability; the expressions of calcium channel α1C subunit and β1 subunit mRNA decreased 22% and 26%, respectively, when compared with the control group; ultrastructure of atrial myocytes changed significantly. AERP of spironotlactone group shortened less that RAP group, and the frequency adaptability was maintained, the decreased expressions of calcium channel α1C subunit and β1 subunit mRNA significantly reduced. RAP could cause atrial remodeling, while spironolactone could inhibit RAP-induced atrial remodeling.</description><identifier>ISSN: 1011-601X</identifier><identifier>PMID: 26826809</identifier><language>eng</language><publisher>Pakistan: Pakistan Journal of Pharmaceutical Sciences</publisher><subject>Animals ; Atrial Remodeling - drug effects ; Calcium Channels, L-Type - genetics ; Cardiac Pacing, Artificial ; Female ; Heart atrium ; Male ; Patient outcomes ; Rabbits ; Refractory Period, Electrophysiological - drug effects ; Renin-Angiotensin System - physiology ; Spironolactone ; Spironolactone - pharmacology ; Time Factors</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2016-01, Vol.29 (1), p.151-156</ispartof><rights>COPYRIGHT 2016 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26826809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Lian-Fa</creatorcontrib><creatorcontrib>Gu, Lei</creatorcontrib><creatorcontrib>Huang, Meng-Xun</creatorcontrib><creatorcontrib>Zhou, Wen-Bing</creatorcontrib><creatorcontrib>Li, Hua</creatorcontrib><creatorcontrib>Zhang, Bang-Zhu</creatorcontrib><title>Effects of spironolactone towards rabbit atrial remodeling with rapid pacing</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>This study aimed to observe the effects of spironolactone towards the rabbit atrial remodeling with rapid atrial pacing (RAP). 30 rabbits were randomly divided into control group, RAP group and spironolactone group, with 10 rabbits in each group. RAP was performed at the speed of 800 beats/min for 8 h, atrial effective refractory period (AERP) was determined before and at the 1(st), 2(nd), 4(th), 6(th) and 8(th) of the pacing, the expressions of atrial muscular calcium channel α1C subunit and β1 subunit mRNA were performed the RT-PCR detection, and ultrastructural changes of atrial myocytes were observed. AERP of RAP group shortened, with poor frequency adaptability; the expressions of calcium channel α1C subunit and β1 subunit mRNA decreased 22% and 26%, respectively, when compared with the control group; ultrastructure of atrial myocytes changed significantly. AERP of spironotlactone group shortened less that RAP group, and the frequency adaptability was maintained, the decreased expressions of calcium channel α1C subunit and β1 subunit mRNA significantly reduced. RAP could cause atrial remodeling, while spironolactone could inhibit RAP-induced atrial remodeling.</description><subject>Animals</subject><subject>Atrial Remodeling - drug effects</subject><subject>Calcium Channels, L-Type - genetics</subject><subject>Cardiac Pacing, Artificial</subject><subject>Female</subject><subject>Heart atrium</subject><subject>Male</subject><subject>Patient outcomes</subject><subject>Rabbits</subject><subject>Refractory Period, Electrophysiological - drug effects</subject><subject>Renin-Angiotensin System - physiology</subject><subject>Spironolactone</subject><subject>Spironolactone - pharmacology</subject><subject>Time Factors</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtLAzEUhbNQbK3-BQm4cTOS1ySTZSn1AQU3Cu6GPGtkZjImKcV_75TWhSD3woVzv3u4nDMwxwjjiiP8PgOXOX8ixJmU8gLMCG-mRnIONmvvnSkZRg_zGFIcYqdMiYODJe5VshkmpXUoUJUUVAeT66N1XRi2cB_Kx7Qdg4WjMpNyBc696rK7Ps0FeHtYv66eqs3L4_Nquam2RDSlqjkSwghrFWWMES29003NBULWEiW0Mo2unSHU1N7WqKbaSCqEk5xjLBChC3B39B1T_Nq5XNo-ZOO6Tg0u7nKLBSeISCLohN4e0a3qXBsGH0tS5oC3S8YaxrDAB-r-H2oq6_pgpjB8mPQ_BzenD3a6d7YdU-hV-m5_g6U_zgxyIQ</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Wang, Lian-Fa</creator><creator>Gu, Lei</creator><creator>Huang, Meng-Xun</creator><creator>Zhou, Wen-Bing</creator><creator>Li, Hua</creator><creator>Zhang, Bang-Zhu</creator><general>Pakistan Journal of Pharmaceutical Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201601</creationdate><title>Effects of spironolactone towards rabbit atrial remodeling with rapid pacing</title><author>Wang, Lian-Fa ; Gu, Lei ; Huang, Meng-Xun ; Zhou, Wen-Bing ; Li, Hua ; Zhang, Bang-Zhu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g278t-56077c7dda34442b9feb856700dd2a7bac8b5ec23c5fd5053bc9377e966117023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Atrial Remodeling - drug effects</topic><topic>Calcium Channels, L-Type - genetics</topic><topic>Cardiac Pacing, Artificial</topic><topic>Female</topic><topic>Heart atrium</topic><topic>Male</topic><topic>Patient outcomes</topic><topic>Rabbits</topic><topic>Refractory Period, Electrophysiological - drug effects</topic><topic>Renin-Angiotensin System - physiology</topic><topic>Spironolactone</topic><topic>Spironolactone - pharmacology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Lian-Fa</creatorcontrib><creatorcontrib>Gu, Lei</creatorcontrib><creatorcontrib>Huang, Meng-Xun</creatorcontrib><creatorcontrib>Zhou, Wen-Bing</creatorcontrib><creatorcontrib>Li, Hua</creatorcontrib><creatorcontrib>Zhang, Bang-Zhu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Lian-Fa</au><au>Gu, Lei</au><au>Huang, Meng-Xun</au><au>Zhou, Wen-Bing</au><au>Li, Hua</au><au>Zhang, Bang-Zhu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of spironolactone towards rabbit atrial remodeling with rapid pacing</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2016-01</date><risdate>2016</risdate><volume>29</volume><issue>1</issue><spage>151</spage><epage>156</epage><pages>151-156</pages><issn>1011-601X</issn><abstract>This study aimed to observe the effects of spironolactone towards the rabbit atrial remodeling with rapid atrial pacing (RAP). 30 rabbits were randomly divided into control group, RAP group and spironolactone group, with 10 rabbits in each group. RAP was performed at the speed of 800 beats/min for 8 h, atrial effective refractory period (AERP) was determined before and at the 1(st), 2(nd), 4(th), 6(th) and 8(th) of the pacing, the expressions of atrial muscular calcium channel α1C subunit and β1 subunit mRNA were performed the RT-PCR detection, and ultrastructural changes of atrial myocytes were observed. AERP of RAP group shortened, with poor frequency adaptability; the expressions of calcium channel α1C subunit and β1 subunit mRNA decreased 22% and 26%, respectively, when compared with the control group; ultrastructure of atrial myocytes changed significantly. AERP of spironotlactone group shortened less that RAP group, and the frequency adaptability was maintained, the decreased expressions of calcium channel α1C subunit and β1 subunit mRNA significantly reduced. RAP could cause atrial remodeling, while spironolactone could inhibit RAP-induced atrial remodeling.</abstract><cop>Pakistan</cop><pub>Pakistan Journal of Pharmaceutical Sciences</pub><pmid>26826809</pmid><tpages>6</tpages></addata></record> |
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| subjects | Animals Atrial Remodeling - drug effects Calcium Channels, L-Type - genetics Cardiac Pacing, Artificial Female Heart atrium Male Patient outcomes Rabbits Refractory Period, Electrophysiological - drug effects Renin-Angiotensin System - physiology Spironolactone Spironolactone - pharmacology Time Factors |
| title | Effects of spironolactone towards rabbit atrial remodeling with rapid pacing |
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