Anti-ulcer activity of the aqueous extract of Melastoma malabathricum L. leaf in rats

Melastoma malabathricum L. Smith (Melastomaceae) has been used in the Malay traditional culture to treat ulcer-based ailments.The objective of the present study was to investigate the potential anti-ulcer effect of aqueous extract of M. malabathricum leaves (AEMM) using ethanol- and indomethacin-ind...

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Veröffentlicht in:	Pakistan journal of pharmaceutical sciences 2016-01, Vol.29 (1), p.35-38
Hauptverfasser:	Wan Zainulddin, Wan-Noraziemah, Zabidi, Zalina, Kamisan, Farah Hidayah, Yahya, Farhana, Ismail, Noor Aisyah, Nor Shamsahal Din, Nor Shafawati, Mamat, Siti Syariah, Hassan, Hadijah, Mohtarrudin, Norhafizah, Zakaria, Zainul Amiruddin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Ulcer Agents - pharmacology Care and treatment Health aspects Male Materia medica, Vegetable Melastomataceae Peptic ulcer Plant extracts Plant Extracts - pharmacology Plant Leaves Rats Rats, Sprague-Dawley Rosidae
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Zusammenfassung:	Melastoma malabathricum L. Smith (Melastomaceae) has been used in the Malay traditional culture to treat ulcer-based ailments.The objective of the present study was to investigate the potential anti-ulcer effect of aqueous extract of M. malabathricum leaves (AEMM) using ethanol- and indomethacin-induced gastric ulcer models in rats. Rats were divided into ten groups (n=6) and received DMSO (10%; negative group), ranitidine (100mg/kg; positive group) or AEMM (50, 250 and 500mg/kg) orally for 7 days and on the 8(th) day subjected to the respective gastric ulcer models. The stomachs were collected and subjected to macroscopic and microscopic analysis. At all groups tested, the AEMM exerted significant (p
ISSN:	1011-601X