Pharmacological profiles of selective non-peptidic δ opioid receptor ligands

Several non-peptidic opioids have been synthesized recently as part of a program to develop selective δ receptor agonists. In this study, the affinities of a set of compounds for cloned δ and μ opioid receptors expressed in HEK 293 cell lines were determined by competition analysis of [ 3H]bremazoci...

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Veröffentlicht in:	Brain research. Molecular brain research. 2000-09, Vol.80 (2), p.166-176
Hauptverfasser:	Chaturvedi, Kirti, Jiang, Xiuju, Christoffers, Keith H, Chinen, Norihiro, Bandari, Persis, Raveglia, Luca F, Ronzoni, Silvano, Dondio, Giulio, Howells, Richard D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analgesics - metabolism Analgesics - pharmacology Analgesics, Opioid - metabolism Analgesics, Opioid - pharmacology Benzomorphans - metabolism Benzomorphans - pharmacology Binding, Competitive Biological and medical sciences Cell receptors Cell structures and functions Cells, Cultured Cloning, Molecular Delta opioid receptor Down-Regulation - drug effects Down-Regulation - physiology Enkephalin, Leucine-2-Alanine - pharmacology Fundamental and applied biological sciences. Psychology G protein-coupled receptor GTP-Binding Proteins - metabolism Heterocyclic Compounds, 4 or More Rings - chemistry Heterocyclic Compounds, 4 or More Rings - pharmacology Humans Indoles - chemistry Indoles - pharmacology Isoquinolines - chemistry Isoquinolines - pharmacology Kidney - cytology Ligands MAP kinase Mitogen-Activated Protein Kinases - metabolism Molecular and cellular biology Molecular Sequence Data Morphine Morphine - metabolism Morphine - pharmacology Mutagenesis, Site-Directed Naloxone - pharmacology Narcotic Antagonists - pharmacology Neuropeptide receptors Opioid peptide Quinolines - chemistry Quinolines - metabolism Quinolines - pharmacology Radioligand Assay Receptor down regulation Receptors, Opioid, delta - agonists Receptors, Opioid, delta - antagonists & inhibitors Receptors, Opioid, delta - genetics Receptors, Opioid, mu - agonists Receptors, Opioid, mu - antagonists & inhibitors Receptors, Opioid, mu - genetics Tritium
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