Simvastatin Modulates Cytokine-Mediated Endothelial Cell Adhesion Molecule Induction: Involvement of an Inhibitory G Protein

Endothelial cell adhesion molecules (CAMs) E-selectin, ICAM-1, and VCAM-1 play variably important roles in immune-mediated processes. They are induced by the proinflammatory cytokines IL-1 and TNF-alpha, and NF-kappaB is required for the regulated expression of all three genes. Regulators of this pa...

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Veröffentlicht in:	The Journal of immunology (1950) 2000-09, Vol.165 (5), p.2712-2718
Hauptverfasser:	Sadeghi, Mehran M, Collinge, Mark, Pardi, Ruggero, Bender, Jeffrey R
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion molecules Adjuvants, Immunologic - pharmacology Biological Transport - drug effects Biological Transport - immunology Cell Adhesion Molecules - biosynthesis Cells, Cultured Cholesterol - biosynthesis Cytokines - physiology Drug Synergism E-selectin E-Selectin - biosynthesis E-Selectin - genetics Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Endothelium, Vascular - immunology Endothelium, Vascular - metabolism Gene Expression Regulation - drug effects Gene Expression Regulation - immunology GTP-Binding Protein alpha Subunits, Gi-Go - physiology Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology intercellular adhesion molecule 1 Intercellular Adhesion Molecule-1 - biosynthesis Interleukin-1 - antagonists & inhibitors Interleukin-1 - physiology NF-kappa B - metabolism RNA, Messenger - metabolism Signal Transduction - immunology simvastatin Simvastatin - pharmacology Sodium Fluoride - pharmacology Umbilical Veins vascular cell adhesion molecule 1 Vascular Cell Adhesion Molecule-1 - biosynthesis
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