Structure of Functionally Activated Small Ribosomal Subunit at 3.3 Angstrom Resolution
The small ribosomal subunit performs the decoding of genetic information during translation. The structure of that from Thermus thermophilus shows that the decoding center, which positions mRNA and three tRNAs, is constructed entirely of RNA. The entrance to the mRNA channel will encircle the messag...
Gespeichert in:
| Veröffentlicht in: | Cell 2000-09, Vol.102 (5), p.615-623 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 623 |
|---|---|
| container_issue | 5 |
| container_start_page | 615 |
| container_title | Cell |
| container_volume | 102 |
| creator | Schluenzen, F Tocilj, A Zarivach, R Harms, J Gluehmann, M Janell, D Bashan, A Bartels, H Agmon, I Franceschi, F Yonath, A |
| description | The small ribosomal subunit performs the decoding of genetic information during translation. The structure of that from Thermus thermophilus shows that the decoding center, which positions mRNA and three tRNAs, is constructed entirely of RNA. The entrance to the mRNA channel will encircle the message when a latch-like contact closes and contributes to processivity and fidelity. Extended RNA helical elements that run longitudinally through the body transmit structural changes, correlating events at the particle's far end with the cycle of mRNA translocation at the decoding region. 96% of the nucleotides were traced and the main fold of all proteins was determined. The latter are either peripheral or appear to serve as linkers. Some may assist the directionality of translocation. |
| doi_str_mv | 10.1016/S0092-8674(00)00084-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_17617480</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17617480</sourcerecordid><originalsourceid>FETCH-LOGICAL-p116t-6edab81dca6ded848a12cd45900631e9fff13a12f5773ace9f3212890ea744773</originalsourceid><addsrcrecordid>eNo9zM9LwzAcBfAcFJzTP0HISfTQ-U2TpumxDKfCQFjV60jzQyppM5tE8L83Q_H0Hp8HD6ErAisChN91AE1ZCF6zG4BbABCsKE_Q4p_P0HkIH8ehqqoFeuvinFRMs8He4k2aVBz8JJ37xm2uXzIajbsxA94NvQ8-V9ylPk1DxDJiuqK4nd5DnP2IdyZ4l44HF-jUShfM5V8u0evm_mX9WGyfH57W7bY4EMJjwY2WvSBaSa6NFkxIUirNqgaAU2Iaay2h2WxV11SqDLQkpWjAyJqxbEt0_ft7mP1nMiHuxyEo45ycjE9hT2pOaiaA_gDduFP_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17617480</pqid></control><display><type>article</type><title>Structure of Functionally Activated Small Ribosomal Subunit at 3.3 Angstrom Resolution</title><source>Cell Press Free Archives</source><source>Access via ScienceDirect (Elsevier)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Schluenzen, F ; Tocilj, A ; Zarivach, R ; Harms, J ; Gluehmann, M ; Janell, D ; Bashan, A ; Bartels, H ; Agmon, I ; Franceschi, F ; Yonath, A</creator><creatorcontrib>Schluenzen, F ; Tocilj, A ; Zarivach, R ; Harms, J ; Gluehmann, M ; Janell, D ; Bashan, A ; Bartels, H ; Agmon, I ; Franceschi, F ; Yonath, A</creatorcontrib><description>The small ribosomal subunit performs the decoding of genetic information during translation. The structure of that from Thermus thermophilus shows that the decoding center, which positions mRNA and three tRNAs, is constructed entirely of RNA. The entrance to the mRNA channel will encircle the message when a latch-like contact closes and contributes to processivity and fidelity. Extended RNA helical elements that run longitudinally through the body transmit structural changes, correlating events at the particle's far end with the cycle of mRNA translocation at the decoding region. 96% of the nucleotides were traced and the main fold of all proteins was determined. The latter are either peripheral or appear to serve as linkers. Some may assist the directionality of translocation.</description><identifier>ISSN: 0092-8674</identifier><identifier>DOI: 10.1016/S0092-8674(00)00084-2</identifier><language>eng</language><subject>Thermus thermophilus</subject><ispartof>Cell, 2000-09, Vol.102 (5), p.615-623</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Schluenzen, F</creatorcontrib><creatorcontrib>Tocilj, A</creatorcontrib><creatorcontrib>Zarivach, R</creatorcontrib><creatorcontrib>Harms, J</creatorcontrib><creatorcontrib>Gluehmann, M</creatorcontrib><creatorcontrib>Janell, D</creatorcontrib><creatorcontrib>Bashan, A</creatorcontrib><creatorcontrib>Bartels, H</creatorcontrib><creatorcontrib>Agmon, I</creatorcontrib><creatorcontrib>Franceschi, F</creatorcontrib><creatorcontrib>Yonath, A</creatorcontrib><title>Structure of Functionally Activated Small Ribosomal Subunit at 3.3 Angstrom Resolution</title><title>Cell</title><description>The small ribosomal subunit performs the decoding of genetic information during translation. The structure of that from Thermus thermophilus shows that the decoding center, which positions mRNA and three tRNAs, is constructed entirely of RNA. The entrance to the mRNA channel will encircle the message when a latch-like contact closes and contributes to processivity and fidelity. Extended RNA helical elements that run longitudinally through the body transmit structural changes, correlating events at the particle's far end with the cycle of mRNA translocation at the decoding region. 96% of the nucleotides were traced and the main fold of all proteins was determined. The latter are either peripheral or appear to serve as linkers. Some may assist the directionality of translocation.</description><subject>Thermus thermophilus</subject><issn>0092-8674</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNo9zM9LwzAcBfAcFJzTP0HISfTQ-U2TpumxDKfCQFjV60jzQyppM5tE8L83Q_H0Hp8HD6ErAisChN91AE1ZCF6zG4BbABCsKE_Q4p_P0HkIH8ehqqoFeuvinFRMs8He4k2aVBz8JJ37xm2uXzIajbsxA94NvQ8-V9ylPk1DxDJiuqK4nd5DnP2IdyZ4l44HF-jUShfM5V8u0evm_mX9WGyfH57W7bY4EMJjwY2WvSBaSa6NFkxIUirNqgaAU2Iaay2h2WxV11SqDLQkpWjAyJqxbEt0_ft7mP1nMiHuxyEo45ycjE9hT2pOaiaA_gDduFP_</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>Schluenzen, F</creator><creator>Tocilj, A</creator><creator>Zarivach, R</creator><creator>Harms, J</creator><creator>Gluehmann, M</creator><creator>Janell, D</creator><creator>Bashan, A</creator><creator>Bartels, H</creator><creator>Agmon, I</creator><creator>Franceschi, F</creator><creator>Yonath, A</creator><scope>7QL</scope><scope>7TM</scope><scope>C1K</scope></search><sort><creationdate>20000901</creationdate><title>Structure of Functionally Activated Small Ribosomal Subunit at 3.3 Angstrom Resolution</title><author>Schluenzen, F ; Tocilj, A ; Zarivach, R ; Harms, J ; Gluehmann, M ; Janell, D ; Bashan, A ; Bartels, H ; Agmon, I ; Franceschi, F ; Yonath, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p116t-6edab81dca6ded848a12cd45900631e9fff13a12f5773ace9f3212890ea744773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Thermus thermophilus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schluenzen, F</creatorcontrib><creatorcontrib>Tocilj, A</creatorcontrib><creatorcontrib>Zarivach, R</creatorcontrib><creatorcontrib>Harms, J</creatorcontrib><creatorcontrib>Gluehmann, M</creatorcontrib><creatorcontrib>Janell, D</creatorcontrib><creatorcontrib>Bashan, A</creatorcontrib><creatorcontrib>Bartels, H</creatorcontrib><creatorcontrib>Agmon, I</creatorcontrib><creatorcontrib>Franceschi, F</creatorcontrib><creatorcontrib>Yonath, A</creatorcontrib><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nucleic Acids Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schluenzen, F</au><au>Tocilj, A</au><au>Zarivach, R</au><au>Harms, J</au><au>Gluehmann, M</au><au>Janell, D</au><au>Bashan, A</au><au>Bartels, H</au><au>Agmon, I</au><au>Franceschi, F</au><au>Yonath, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structure of Functionally Activated Small Ribosomal Subunit at 3.3 Angstrom Resolution</atitle><jtitle>Cell</jtitle><date>2000-09-01</date><risdate>2000</risdate><volume>102</volume><issue>5</issue><spage>615</spage><epage>623</epage><pages>615-623</pages><issn>0092-8674</issn><abstract>The small ribosomal subunit performs the decoding of genetic information during translation. The structure of that from Thermus thermophilus shows that the decoding center, which positions mRNA and three tRNAs, is constructed entirely of RNA. The entrance to the mRNA channel will encircle the message when a latch-like contact closes and contributes to processivity and fidelity. Extended RNA helical elements that run longitudinally through the body transmit structural changes, correlating events at the particle's far end with the cycle of mRNA translocation at the decoding region. 96% of the nucleotides were traced and the main fold of all proteins was determined. The latter are either peripheral or appear to serve as linkers. Some may assist the directionality of translocation.</abstract><doi>10.1016/S0092-8674(00)00084-2</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0092-8674 |
| ispartof | Cell, 2000-09, Vol.102 (5), p.615-623 |
| issn | 0092-8674 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17617480 |
| source | Cell Press Free Archives; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Thermus thermophilus |
| title | Structure of Functionally Activated Small Ribosomal Subunit at 3.3 Angstrom Resolution |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T02%3A53%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Structure%20of%20Functionally%20Activated%20Small%20Ribosomal%20Subunit%20at%203.3%20Angstrom%20Resolution&rft.jtitle=Cell&rft.au=Schluenzen,%20F&rft.date=2000-09-01&rft.volume=102&rft.issue=5&rft.spage=615&rft.epage=623&rft.pages=615-623&rft.issn=0092-8674&rft_id=info:doi/10.1016/S0092-8674(00)00084-2&rft_dat=%3Cproquest%3E17617480%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17617480&rft_id=info:pmid/&rfr_iscdi=true |