Losartan and captopril treatment rescue normal thrombus formation in microfibril associated glycoprotein-1 (MAGP1) deficient mice

Abstract Introduction MAGP1 is a glycoprotein present in the elastic fibers and is a part of the microfibrils components. MAGP1 interacts with von Willebrand factor and the active form of TGF-β and BMP. In mice lacking MAGP1, thrombus formation is delayed, increasing the occlusion time of carotid ar...

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Veröffentlicht in:	Thrombosis research 2016-02, Vol.138, p.7-15
Hauptverfasser:	Vassequi-Silva, Tallita, Pereira, Danielle Sousa, Nery Diez, Ana Cláudia C, Braga, Guilherme G, Godoy, Juliana A, Mendes, Camila B, dos Santos, Leonardo, Krieger, José E, Antunes, Edson, Costa, Fábio T.M, Vicente, Cristina P, Werneck, Claudio C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - therapeutic use Antihypertensive drugs Arterial thrombosis Captopril - therapeutic use Carotid Arteries - drug effects Carotid Arteries - metabolism Carotid Arteries - physiopathology Contractile Proteins - genetics Contractile Proteins - metabolism Extracellular matrix Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Gelatinases - metabolism Gene Deletion Hematology, Oncology and Palliative Medicine Losartan - therapeutic use Male Matrix metalloproteinases Mice Mice, Inbred C57BL Microfibril-associated glycoprotein Platelet Aggregation - drug effects Platelet Function Tests Thrombosis - drug therapy Thrombosis - genetics Thrombosis - metabolism Thrombosis - physiopathology Transforming Growth Factor beta - metabolism Transforming growth factor-β
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