A double blind randomized trial of unilateral left and bilateral prefrontal cortex transcranial magnetic stimulation in treatment resistant major depression
Abstract Objective A substantive body of research has demonstrated the efficacy of repetitive transcranial magnetic stimulation treatment (rTMS) in patients with depression. However, the parameters needed to optimize therapeutic efficacy remain unclear. The aim of this study was to investigate wheth...
Gespeichert in:
| Veröffentlicht in: | Journal of affective disorders 2012-07, Vol.139 (2), p.193-198 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 198 |
|---|---|
| container_issue | 2 |
| container_start_page | 193 |
| container_title | Journal of affective disorders |
| container_volume | 139 |
| creator | Fitzgerald, Paul B Hoy, Kate E Herring, Sally E McQueen, Susan Peachey, Amy V.J Segrave, Rebecca A Maller, Jerome Hall, Phillip Daskalakis, Z. Jeff |
| description | Abstract Objective A substantive body of research has demonstrated the efficacy of repetitive transcranial magnetic stimulation treatment (rTMS) in patients with depression. However, the parameters needed to optimize therapeutic efficacy remain unclear. The aim of this study was to investigate whether there is an advantage in efficacy of sequential bilateral rTMS compared to standard high-frequency left sided rTMS. Method Sixty seven patients with treatment resistant depression were included in a randomised double-blind sham controlled trial of sequential bilateral rTMS compared to standard high-frequency left sided rTMS and sham rTMS over a three-week period. The study also included a further three week comparison of the two active treatment conditions. The primary outcome variable was scores on the 17-item Hamilton Depression Rating Scale (HAMD). Results In the three-week double-blind phase of the trial there was a greater antidepressant response to unilateral left sided rTMS compared with sham or bilateral rTMS. Across the full six weeks of active rTMS, there was also a consistent pattern of improved response in unilateral left compared to bilateral treatment. Response rates were low in both active groups. Conclusions This study does not support the hypothesis that sequential bilateral rTMS is more effective than unilateral high-frequency left-sided rTMS. |
| doi_str_mv | 10.1016/j.jad.2012.02.017 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1761653815</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165032712001139</els_id><sourcerecordid>1038110416</sourcerecordid><originalsourceid>FETCH-LOGICAL-c603t-f5c1e21452099c81e29f1c3dd21ab2f1a9a2df9de3897237ba1cb8562ec474e93</originalsourceid><addsrcrecordid>eNqNkk2LFDEQhhtR3HX0B3iRXAQvM6bSH-kgCMviFyx4UM8hnVRL2u5kTNLi-lv8sdYw4woeXCEklfC8laTqrarHwHfAoXs-7SbjdoKD2HEaIO9U59DKeitakHerc2LaLa-FPKse5Dxxzjsl-f3qTIhayV7x8-rnBXNxHWZkw-yDY8kEFxf_Ax0ryZuZxZGtwc-mYKLdjGNhhLDh5mifcEwxFAptTAW_k9CEbGk66BfzOWDxluXil5VEPgbmA0FoyoKhsITZ52IoWswUE3NIKXMm7mF1bzRzxkendVN9ev3q4-Xb7dX7N-8uL662tuN12Y6tBRTQtIIrZXuK1Qi2dk6AGcQIRhnhRuWw7pUUtRwM2KFvO4G2kQ2qelM9O-bdp_h1xVz04rPFeTYB45o1yI4qWffQ3o42qqNbVN_cjnLKCLyB7j9QwXnTA71-U8ERtSnmTLXX--QXk64J0gdX6EmTK_TBFZrTAEmaJ6f067Cgu1H8tgEBT0-AydbMI_XO-vyHozLLTgBxL44cUje-eUw6W4_BovMJbdEu-n8-4-Vfakue83ThF7zGPMU1BWqzBp1JoD8c7HtwL9DnAWpV_wKATevg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1020048172</pqid></control><display><type>article</type><title>A double blind randomized trial of unilateral left and bilateral prefrontal cortex transcranial magnetic stimulation in treatment resistant major depression</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><creator>Fitzgerald, Paul B ; Hoy, Kate E ; Herring, Sally E ; McQueen, Susan ; Peachey, Amy V.J ; Segrave, Rebecca A ; Maller, Jerome ; Hall, Phillip ; Daskalakis, Z. Jeff</creator><creatorcontrib>Fitzgerald, Paul B ; Hoy, Kate E ; Herring, Sally E ; McQueen, Susan ; Peachey, Amy V.J ; Segrave, Rebecca A ; Maller, Jerome ; Hall, Phillip ; Daskalakis, Z. Jeff</creatorcontrib><description>Abstract Objective A substantive body of research has demonstrated the efficacy of repetitive transcranial magnetic stimulation treatment (rTMS) in patients with depression. However, the parameters needed to optimize therapeutic efficacy remain unclear. The aim of this study was to investigate whether there is an advantage in efficacy of sequential bilateral rTMS compared to standard high-frequency left sided rTMS. Method Sixty seven patients with treatment resistant depression were included in a randomised double-blind sham controlled trial of sequential bilateral rTMS compared to standard high-frequency left sided rTMS and sham rTMS over a three-week period. The study also included a further three week comparison of the two active treatment conditions. The primary outcome variable was scores on the 17-item Hamilton Depression Rating Scale (HAMD). Results In the three-week double-blind phase of the trial there was a greater antidepressant response to unilateral left sided rTMS compared with sham or bilateral rTMS. Across the full six weeks of active rTMS, there was also a consistent pattern of improved response in unilateral left compared to bilateral treatment. Response rates were low in both active groups. Conclusions This study does not support the hypothesis that sequential bilateral rTMS is more effective than unilateral high-frequency left-sided rTMS.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2012.02.017</identifier><identifier>PMID: 22397890</identifier><identifier>CODEN: JADID7</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Adult ; Adult and adolescent clinical studies ; Affective disorders ; Antidepressant ; Antidepressant drugs ; Biological and medical sciences ; Depression ; Depressive Disorder, Major - therapy ; Depressive Disorder, Treatment-Resistant - therapy ; Double blind randomized trials ; Double-Blind Method ; Efficacy ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Mood disorders ; Neuropharmacology ; Pharmacology. Drug treatments ; Prefrontal cortex ; Psychiatry ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychopharmacology ; Refractory depression ; Remission ; Repetitive transcranial magnetic stimulation ; Response ; Response rate ; Transcranial Magnetic Stimulation ; Treatment Outcome</subject><ispartof>Journal of affective disorders, 2012-07, Vol.139 (2), p.193-198</ispartof><rights>Elsevier B.V.</rights><rights>2012 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c603t-f5c1e21452099c81e29f1c3dd21ab2f1a9a2df9de3897237ba1cb8562ec474e93</citedby><cites>FETCH-LOGICAL-c603t-f5c1e21452099c81e29f1c3dd21ab2f1a9a2df9de3897237ba1cb8562ec474e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jad.2012.02.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,30999,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26037621$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22397890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fitzgerald, Paul B</creatorcontrib><creatorcontrib>Hoy, Kate E</creatorcontrib><creatorcontrib>Herring, Sally E</creatorcontrib><creatorcontrib>McQueen, Susan</creatorcontrib><creatorcontrib>Peachey, Amy V.J</creatorcontrib><creatorcontrib>Segrave, Rebecca A</creatorcontrib><creatorcontrib>Maller, Jerome</creatorcontrib><creatorcontrib>Hall, Phillip</creatorcontrib><creatorcontrib>Daskalakis, Z. Jeff</creatorcontrib><title>A double blind randomized trial of unilateral left and bilateral prefrontal cortex transcranial magnetic stimulation in treatment resistant major depression</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>Abstract Objective A substantive body of research has demonstrated the efficacy of repetitive transcranial magnetic stimulation treatment (rTMS) in patients with depression. However, the parameters needed to optimize therapeutic efficacy remain unclear. The aim of this study was to investigate whether there is an advantage in efficacy of sequential bilateral rTMS compared to standard high-frequency left sided rTMS. Method Sixty seven patients with treatment resistant depression were included in a randomised double-blind sham controlled trial of sequential bilateral rTMS compared to standard high-frequency left sided rTMS and sham rTMS over a three-week period. The study also included a further three week comparison of the two active treatment conditions. The primary outcome variable was scores on the 17-item Hamilton Depression Rating Scale (HAMD). Results In the three-week double-blind phase of the trial there was a greater antidepressant response to unilateral left sided rTMS compared with sham or bilateral rTMS. Across the full six weeks of active rTMS, there was also a consistent pattern of improved response in unilateral left compared to bilateral treatment. Response rates were low in both active groups. Conclusions This study does not support the hypothesis that sequential bilateral rTMS is more effective than unilateral high-frequency left-sided rTMS.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Affective disorders</subject><subject>Antidepressant</subject><subject>Antidepressant drugs</subject><subject>Biological and medical sciences</subject><subject>Depression</subject><subject>Depressive Disorder, Major - therapy</subject><subject>Depressive Disorder, Treatment-Resistant - therapy</subject><subject>Double blind randomized trials</subject><subject>Double-Blind Method</subject><subject>Efficacy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Prefrontal cortex</subject><subject>Psychiatry</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Refractory depression</subject><subject>Remission</subject><subject>Repetitive transcranial magnetic stimulation</subject><subject>Response</subject><subject>Response rate</subject><subject>Transcranial Magnetic Stimulation</subject><subject>Treatment Outcome</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkk2LFDEQhhtR3HX0B3iRXAQvM6bSH-kgCMviFyx4UM8hnVRL2u5kTNLi-lv8sdYw4woeXCEklfC8laTqrarHwHfAoXs-7SbjdoKD2HEaIO9U59DKeitakHerc2LaLa-FPKse5Dxxzjsl-f3qTIhayV7x8-rnBXNxHWZkw-yDY8kEFxf_Ax0ryZuZxZGtwc-mYKLdjGNhhLDh5mifcEwxFAptTAW_k9CEbGk66BfzOWDxluXil5VEPgbmA0FoyoKhsITZ52IoWswUE3NIKXMm7mF1bzRzxkendVN9ev3q4-Xb7dX7N-8uL662tuN12Y6tBRTQtIIrZXuK1Qi2dk6AGcQIRhnhRuWw7pUUtRwM2KFvO4G2kQ2qelM9O-bdp_h1xVz04rPFeTYB45o1yI4qWffQ3o42qqNbVN_cjnLKCLyB7j9QwXnTA71-U8ERtSnmTLXX--QXk64J0gdX6EmTK_TBFZrTAEmaJ6f067Cgu1H8tgEBT0-AydbMI_XO-vyHozLLTgBxL44cUje-eUw6W4_BovMJbdEu-n8-4-Vfakue83ThF7zGPMU1BWqzBp1JoD8c7HtwL9DnAWpV_wKATevg</recordid><startdate>20120701</startdate><enddate>20120701</enddate><creator>Fitzgerald, Paul B</creator><creator>Hoy, Kate E</creator><creator>Herring, Sally E</creator><creator>McQueen, Susan</creator><creator>Peachey, Amy V.J</creator><creator>Segrave, Rebecca A</creator><creator>Maller, Jerome</creator><creator>Hall, Phillip</creator><creator>Daskalakis, Z. Jeff</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QJ</scope><scope>7TK</scope></search><sort><creationdate>20120701</creationdate><title>A double blind randomized trial of unilateral left and bilateral prefrontal cortex transcranial magnetic stimulation in treatment resistant major depression</title><author>Fitzgerald, Paul B ; Hoy, Kate E ; Herring, Sally E ; McQueen, Susan ; Peachey, Amy V.J ; Segrave, Rebecca A ; Maller, Jerome ; Hall, Phillip ; Daskalakis, Z. Jeff</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c603t-f5c1e21452099c81e29f1c3dd21ab2f1a9a2df9de3897237ba1cb8562ec474e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Affective disorders</topic><topic>Antidepressant</topic><topic>Antidepressant drugs</topic><topic>Biological and medical sciences</topic><topic>Depression</topic><topic>Depressive Disorder, Major - therapy</topic><topic>Depressive Disorder, Treatment-Resistant - therapy</topic><topic>Double blind randomized trials</topic><topic>Double-Blind Method</topic><topic>Efficacy</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Prefrontal cortex</topic><topic>Psychiatry</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Refractory depression</topic><topic>Remission</topic><topic>Repetitive transcranial magnetic stimulation</topic><topic>Response</topic><topic>Response rate</topic><topic>Transcranial Magnetic Stimulation</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fitzgerald, Paul B</creatorcontrib><creatorcontrib>Hoy, Kate E</creatorcontrib><creatorcontrib>Herring, Sally E</creatorcontrib><creatorcontrib>McQueen, Susan</creatorcontrib><creatorcontrib>Peachey, Amy V.J</creatorcontrib><creatorcontrib>Segrave, Rebecca A</creatorcontrib><creatorcontrib>Maller, Jerome</creatorcontrib><creatorcontrib>Hall, Phillip</creatorcontrib><creatorcontrib>Daskalakis, Z. Jeff</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fitzgerald, Paul B</au><au>Hoy, Kate E</au><au>Herring, Sally E</au><au>McQueen, Susan</au><au>Peachey, Amy V.J</au><au>Segrave, Rebecca A</au><au>Maller, Jerome</au><au>Hall, Phillip</au><au>Daskalakis, Z. Jeff</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A double blind randomized trial of unilateral left and bilateral prefrontal cortex transcranial magnetic stimulation in treatment resistant major depression</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>2012-07-01</date><risdate>2012</risdate><volume>139</volume><issue>2</issue><spage>193</spage><epage>198</epage><pages>193-198</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><coden>JADID7</coden><abstract>Abstract Objective A substantive body of research has demonstrated the efficacy of repetitive transcranial magnetic stimulation treatment (rTMS) in patients with depression. However, the parameters needed to optimize therapeutic efficacy remain unclear. The aim of this study was to investigate whether there is an advantage in efficacy of sequential bilateral rTMS compared to standard high-frequency left sided rTMS. Method Sixty seven patients with treatment resistant depression were included in a randomised double-blind sham controlled trial of sequential bilateral rTMS compared to standard high-frequency left sided rTMS and sham rTMS over a three-week period. The study also included a further three week comparison of the two active treatment conditions. The primary outcome variable was scores on the 17-item Hamilton Depression Rating Scale (HAMD). Results In the three-week double-blind phase of the trial there was a greater antidepressant response to unilateral left sided rTMS compared with sham or bilateral rTMS. Across the full six weeks of active rTMS, there was also a consistent pattern of improved response in unilateral left compared to bilateral treatment. Response rates were low in both active groups. Conclusions This study does not support the hypothesis that sequential bilateral rTMS is more effective than unilateral high-frequency left-sided rTMS.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>22397890</pmid><doi>10.1016/j.jad.2012.02.017</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-0327 |
| ispartof | Journal of affective disorders, 2012-07, Vol.139 (2), p.193-198 |
| issn | 0165-0327 1573-2517 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1761653815 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE; Applied Social Sciences Index & Abstracts (ASSIA) |
| subjects | Adult Adult and adolescent clinical studies Affective disorders Antidepressant Antidepressant drugs Biological and medical sciences Depression Depressive Disorder, Major - therapy Depressive Disorder, Treatment-Resistant - therapy Double blind randomized trials Double-Blind Method Efficacy Female Humans Male Medical sciences Middle Aged Mood disorders Neuropharmacology Pharmacology. Drug treatments Prefrontal cortex Psychiatry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Refractory depression Remission Repetitive transcranial magnetic stimulation Response Response rate Transcranial Magnetic Stimulation Treatment Outcome |
| title | A double blind randomized trial of unilateral left and bilateral prefrontal cortex transcranial magnetic stimulation in treatment resistant major depression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T10%3A07%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20double%20blind%20randomized%20trial%20of%20unilateral%20left%20and%20bilateral%20prefrontal%20cortex%20transcranial%20magnetic%20stimulation%20in%20treatment%20resistant%20major%20depression&rft.jtitle=Journal%20of%20affective%20disorders&rft.au=Fitzgerald,%20Paul%20B&rft.date=2012-07-01&rft.volume=139&rft.issue=2&rft.spage=193&rft.epage=198&rft.pages=193-198&rft.issn=0165-0327&rft.eissn=1573-2517&rft.coden=JADID7&rft_id=info:doi/10.1016/j.jad.2012.02.017&rft_dat=%3Cproquest_cross%3E1038110416%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1020048172&rft_id=info:pmid/22397890&rft_els_id=S0165032712001139&rfr_iscdi=true |