Metacognitive therapy in treatment-resistant depression: A platform trial
Patients with treatment-resistant depression received up to 8 sessions of metacognitive therapy (MCT) targeting attentional control, rumination, worry, and metacognitive beliefs. A baseline period was followed by weekly sessions with follow-up assessments at 6 and 12 months post treatment. Large and...
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| Veröffentlicht in: | Behaviour research and therapy 2012-06, Vol.50 (6), p.367-373 |
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| creator | Wells, Adrian Fisher, Peter Myers, Samuel Wheatley, Jon Patel, Trishna Brewin, Chris R. |
| description | Patients with treatment-resistant depression received up to 8 sessions of metacognitive therapy (MCT) targeting attentional control, rumination, worry, and metacognitive beliefs. A baseline period was followed by weekly sessions with follow-up assessments at 6 and 12 months post treatment. Large and statistically significant improvements occurred in all symptom measures at post treatment and were maintained over follow-up. Two out of 3 process measures significantly improved at post treatment and all of these measures were improved at follow-up. Treatment was associated with similar response rates on the BDI and Hamilton rating scale. Using liberal criteria 80% of completers were classified as recovered at post treatment and 70% at follow-up on the BDI. In the intention to treat sample 66.6% were recovered at post treatment and 58.3% at follow-up. More stringent criteria showed 60% recovery rates at post treatment and at 12m. The results suggest that MCT could be a brief and effective treatment and they provide a precedent for more definitive randomized controlled trials.
► Metacognitive therapy was applied in treatment-resistant depression. ► A mean of 6.5 sessions of treatment was associated with significant improvements. ► Formal recovery rates of 60–80 per cent were observed at post treatment. ► Effects were largely maintained at 12 month follow-up. |
| doi_str_mv | 10.1016/j.brat.2012.02.004 |
| format | Article |
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► Metacognitive therapy was applied in treatment-resistant depression. ► A mean of 6.5 sessions of treatment was associated with significant improvements. ► Formal recovery rates of 60–80 per cent were observed at post treatment. ► Effects were largely maintained at 12 month follow-up.</description><identifier>ISSN: 0005-7967</identifier><identifier>EISSN: 1873-622X</identifier><identifier>DOI: 10.1016/j.brat.2012.02.004</identifier><identifier>PMID: 22498310</identifier><identifier>CODEN: BRTHAA</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adult ; Adult and adolescent clinical studies ; Analysis of Variance ; Antidepressive Agents - therapeutic use ; Behavior modification ; Behavior therapy. Cognitive therapy ; Biological and medical sciences ; Cognition Disorders - etiology ; Cognition Disorders - therapy ; Cognitive Therapy - methods ; Depression ; Depression treatment ; Depressive Disorder, Treatment-Resistant - psychology ; Depressive Disorder, Treatment-Resistant - therapy ; Female ; Humans ; Male ; Medical sciences ; Medical treatment ; Mental depression ; Metacognition ; Metacognitive therapy ; Middle Aged ; Mood disorders ; Psychiatric Status Rating Scales ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Randomized controlled trials ; Recovered ; Response rate ; Rumination ; Studies ; Treatment Outcome ; Treatment-resistant cases ; Treatments</subject><ispartof>Behaviour research and therapy, 2012-06, Vol.50 (6), p.367-373</ispartof><rights>2012 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Pergamon Press Inc. Jun 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c579t-d4eb23d13fae7c6edaa3073db4171ca99d3ee8ecd29ec733363b35a19940a6b33</citedby><cites>FETCH-LOGICAL-c579t-d4eb23d13fae7c6edaa3073db4171ca99d3ee8ecd29ec733363b35a19940a6b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0005796712000319$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,30976,30977,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25887744$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22498310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wells, Adrian</creatorcontrib><creatorcontrib>Fisher, Peter</creatorcontrib><creatorcontrib>Myers, Samuel</creatorcontrib><creatorcontrib>Wheatley, Jon</creatorcontrib><creatorcontrib>Patel, Trishna</creatorcontrib><creatorcontrib>Brewin, Chris R.</creatorcontrib><title>Metacognitive therapy in treatment-resistant depression: A platform trial</title><title>Behaviour research and therapy</title><addtitle>Behav Res Ther</addtitle><description>Patients with treatment-resistant depression received up to 8 sessions of metacognitive therapy (MCT) targeting attentional control, rumination, worry, and metacognitive beliefs. A baseline period was followed by weekly sessions with follow-up assessments at 6 and 12 months post treatment. Large and statistically significant improvements occurred in all symptom measures at post treatment and were maintained over follow-up. Two out of 3 process measures significantly improved at post treatment and all of these measures were improved at follow-up. Treatment was associated with similar response rates on the BDI and Hamilton rating scale. Using liberal criteria 80% of completers were classified as recovered at post treatment and 70% at follow-up on the BDI. In the intention to treat sample 66.6% were recovered at post treatment and 58.3% at follow-up. More stringent criteria showed 60% recovery rates at post treatment and at 12m. The results suggest that MCT could be a brief and effective treatment and they provide a precedent for more definitive randomized controlled trials.
► Metacognitive therapy was applied in treatment-resistant depression. ► A mean of 6.5 sessions of treatment was associated with significant improvements. ► Formal recovery rates of 60–80 per cent were observed at post treatment. ► Effects were largely maintained at 12 month follow-up.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Analysis of Variance</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Behavior modification</subject><subject>Behavior therapy. Cognitive therapy</subject><subject>Biological and medical sciences</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - therapy</subject><subject>Cognitive Therapy - methods</subject><subject>Depression</subject><subject>Depression treatment</subject><subject>Depressive Disorder, Treatment-Resistant - psychology</subject><subject>Depressive Disorder, Treatment-Resistant - therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Mental depression</subject><subject>Metacognition</subject><subject>Metacognitive therapy</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Randomized controlled trials</subject><subject>Recovered</subject><subject>Response rate</subject><subject>Rumination</subject><subject>Studies</subject><subject>Treatment Outcome</subject><subject>Treatment-resistant cases</subject><subject>Treatments</subject><issn>0005-7967</issn><issn>1873-622X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqN0VtrFTEQB_AgFnusfgEfZEEEX_Y0l91cxJdSvBRa-qLg2zKbzGoOu9k1ySn025vlHBV80EIgDPxmSOZPyAtGt4wyeb7b9hHyllPGt7Qc2jwiG6aVqCXnXx-TDaW0rZWR6pQ8TWlXSqE5fUJOOW-MFoxuyNUNZrDzt-Czv8Mqf8cIy33lQ5UjQp4w5Dpi8ilDyJXDpRTJz-FtdVEtI-RhjlOhHsZn5GSAMeHz431Gvnx4__nyU319-_Hq8uK6tq0yuXYN9lw4JgZAZSU6AEGVcH3DFLNgjBOIGq3jBq0SQkjRixaYMQ0F2QtxRt4c5i5x_rHHlLvJJ4vjCAHnfeqYkky2QjH2f1r2wRjVhj6ENppR3vIHUMY5NbptC331F93N-xjKeg5KtVyvP-IHZeOcUsShW6KfIN4XtDrZ7bo16W5NuqPl0KY0vTyO3vcTut8tv6It4PURQLIwDhGC9emPa7VWqlkHvTs4LKHdeYxdsh6DRecj2ty52f_rHT8BeH3E8g</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Wells, Adrian</creator><creator>Fisher, Peter</creator><creator>Myers, Samuel</creator><creator>Wheatley, Jon</creator><creator>Patel, Trishna</creator><creator>Brewin, Chris R.</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Science Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20120601</creationdate><title>Metacognitive therapy in treatment-resistant depression: A platform trial</title><author>Wells, Adrian ; Fisher, Peter ; Myers, Samuel ; Wheatley, Jon ; Patel, Trishna ; Brewin, Chris R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c579t-d4eb23d13fae7c6edaa3073db4171ca99d3ee8ecd29ec733363b35a19940a6b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Analysis of Variance</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Behavior modification</topic><topic>Behavior therapy. Cognitive therapy</topic><topic>Biological and medical sciences</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - therapy</topic><topic>Cognitive Therapy - methods</topic><topic>Depression</topic><topic>Depression treatment</topic><topic>Depressive Disorder, Treatment-Resistant - psychology</topic><topic>Depressive Disorder, Treatment-Resistant - therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Mental depression</topic><topic>Metacognition</topic><topic>Metacognitive therapy</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Randomized controlled trials</topic><topic>Recovered</topic><topic>Response rate</topic><topic>Rumination</topic><topic>Studies</topic><topic>Treatment Outcome</topic><topic>Treatment-resistant cases</topic><topic>Treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wells, Adrian</creatorcontrib><creatorcontrib>Fisher, Peter</creatorcontrib><creatorcontrib>Myers, Samuel</creatorcontrib><creatorcontrib>Wheatley, Jon</creatorcontrib><creatorcontrib>Patel, Trishna</creatorcontrib><creatorcontrib>Brewin, Chris R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behaviour research and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wells, Adrian</au><au>Fisher, Peter</au><au>Myers, Samuel</au><au>Wheatley, Jon</au><au>Patel, Trishna</au><au>Brewin, Chris R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metacognitive therapy in treatment-resistant depression: A platform trial</atitle><jtitle>Behaviour research and therapy</jtitle><addtitle>Behav Res Ther</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>50</volume><issue>6</issue><spage>367</spage><epage>373</epage><pages>367-373</pages><issn>0005-7967</issn><eissn>1873-622X</eissn><coden>BRTHAA</coden><abstract>Patients with treatment-resistant depression received up to 8 sessions of metacognitive therapy (MCT) targeting attentional control, rumination, worry, and metacognitive beliefs. A baseline period was followed by weekly sessions with follow-up assessments at 6 and 12 months post treatment. Large and statistically significant improvements occurred in all symptom measures at post treatment and were maintained over follow-up. Two out of 3 process measures significantly improved at post treatment and all of these measures were improved at follow-up. Treatment was associated with similar response rates on the BDI and Hamilton rating scale. Using liberal criteria 80% of completers were classified as recovered at post treatment and 70% at follow-up on the BDI. In the intention to treat sample 66.6% were recovered at post treatment and 58.3% at follow-up. More stringent criteria showed 60% recovery rates at post treatment and at 12m. The results suggest that MCT could be a brief and effective treatment and they provide a precedent for more definitive randomized controlled trials.
► Metacognitive therapy was applied in treatment-resistant depression. ► A mean of 6.5 sessions of treatment was associated with significant improvements. ► Formal recovery rates of 60–80 per cent were observed at post treatment. ► Effects were largely maintained at 12 month follow-up.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>22498310</pmid><doi>10.1016/j.brat.2012.02.004</doi><tpages>7</tpages></addata></record> |
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| ispartof | Behaviour research and therapy, 2012-06, Vol.50 (6), p.367-373 |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Adult and adolescent clinical studies Analysis of Variance Antidepressive Agents - therapeutic use Behavior modification Behavior therapy. Cognitive therapy Biological and medical sciences Cognition Disorders - etiology Cognition Disorders - therapy Cognitive Therapy - methods Depression Depression treatment Depressive Disorder, Treatment-Resistant - psychology Depressive Disorder, Treatment-Resistant - therapy Female Humans Male Medical sciences Medical treatment Mental depression Metacognition Metacognitive therapy Middle Aged Mood disorders Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Randomized controlled trials Recovered Response rate Rumination Studies Treatment Outcome Treatment-resistant cases Treatments |
| title | Metacognitive therapy in treatment-resistant depression: A platform trial |
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