Effects of group exposure on single injection-induced behavioral sensitization to drugs of abuse in mice
Abstract Background Behavioral sensitization in rodents is hypothesized to reflect neuronal adaptations that are related to drug addiction in humans. We evaluated the effects of group exposure on the acute hyperlocomotion and behavioral sensitization induced by four drugs of abuse in C57BL/6 mice: m...
Gespeichert in:
| Veröffentlicht in: | Drug and alcohol dependence 2011-11, Vol.118 (2), p.349-359 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 359 |
|---|---|
| container_issue | 2 |
| container_start_page | 349 |
| container_title | Drug and alcohol dependence |
| container_volume | 118 |
| creator | Procópio-Souza, Roberta Fukushiro, Daniela F Trombin, Thaís F Wuo-Silva, Raphael Zanlorenci, Lineane H.F Lima, Alexandre J.O Ribeiro, Luciana T.C Corrêa, Jussara M.R.M Marinho, Eduardo A.V Kameda, Sonia R Andersen, Monica L Tufik, Sergio Frussa-Filho, Roberto |
| description | Abstract Background Behavioral sensitization in rodents is hypothesized to reflect neuronal adaptations that are related to drug addiction in humans. We evaluated the effects of group exposure on the acute hyperlocomotion and behavioral sensitization induced by four drugs of abuse in C57BL/6 mice: methylenedioxymethamphetamine (MDMA), d-amphetamine, morphine and ethanol. Methods In the priming session, animals received an ip injection of one of the drugs of abuse and were exposed to an open field either individually or in groups of four. Seven days later, we assessed behavioral sensitization in the challenge session. All animals received an ip injection of the same drug and were exposed to the open field in the same social conditions described for the priming session. Locomotion and social interaction were quantified during each session. Results Acute MDMA, morphine and ethanol, but not d-amphetamine, increased social interaction. However, group exposure only potentiated MDMA-induced hyperlocomotion. After a challenge injection of each drug, there was no sensitization to the facilitating effect of MDMA, morphine or ethanol on social interaction, but locomotion sensitization developed to all drugs of abuse except ethanol. This sensitization was potentiated by group exposure in MDMA-treated animals, attenuated in morphine-treated animals and not modified in d-amphetamine-treated animals. Acute MDMA enhanced body contact and peaceful following, while acute morphine and ethanol increased social sniffing. Conclusions These results provide preclinical evidence showing that while different drugs of abuse affect different components of social interaction, the neuronal adaptations related to drug dependence can be critically and specifically influenced by group exposure. |
| doi_str_mv | 10.1016/j.drugalcdep.2011.04.017 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1761652811</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S037687161100189X</els_id><sourcerecordid>1761652811</sourcerecordid><originalsourceid>FETCH-LOGICAL-c492t-f9c8a0bf4e503f69a274d35dd7394c005fc2d31309ec60f562a01f3fd2c59b803</originalsourceid><addsrcrecordid>eNqNkk2LFDEQhhtR3HH1L0gugpduKx-d7lwEXdYPWPCggreQSSqzGXuSMZleXH-9aWd0wYvmkstTbxX1VNMQCh0FKl9sO5fnjZmsw33HgNIORAd0uNes6DioFkDI-80K-CDbcaDyrHlUyhbqkwoeNmeM9koKxVfN9aX3aA-FJE82Oc17gt_3qcwZSYqkhLiZkIS4rUxIsQ3RzRYdWeO1uQkpm4kUjCUcwg-zAOSQyDLarzyznstSTHbB4uPmgTdTwSen_7z5_Oby08W79urD2_cXr65aKxQ7tF7Z0cDaC-yBe6kMG4TjvXMDV8IC9N4yxykHhVaC7yUzQD33jtlerUfg583zY-4-p28zloPehWJxmkzENBdNB0llz0ZK_43ynrGRgRIVHY-ozamUjF7vc9iZfKsp6EWJ3uo7JXpRokHoqqSWPj11mdc7dH8KfzuowLMTYIo1k88m2lDuOCGZADVW7vWRw7q-m4BZFxswVh0hVz3apfA_07z8K8ROIYba9yveYtmmOceqR1NdmAb9cTmh5YIoBaCj-sJ_Aha9xKw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1352282094</pqid></control><display><type>article</type><title>Effects of group exposure on single injection-induced behavioral sensitization to drugs of abuse in mice</title><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Procópio-Souza, Roberta ; Fukushiro, Daniela F ; Trombin, Thaís F ; Wuo-Silva, Raphael ; Zanlorenci, Lineane H.F ; Lima, Alexandre J.O ; Ribeiro, Luciana T.C ; Corrêa, Jussara M.R.M ; Marinho, Eduardo A.V ; Kameda, Sonia R ; Andersen, Monica L ; Tufik, Sergio ; Frussa-Filho, Roberto</creator><creatorcontrib>Procópio-Souza, Roberta ; Fukushiro, Daniela F ; Trombin, Thaís F ; Wuo-Silva, Raphael ; Zanlorenci, Lineane H.F ; Lima, Alexandre J.O ; Ribeiro, Luciana T.C ; Corrêa, Jussara M.R.M ; Marinho, Eduardo A.V ; Kameda, Sonia R ; Andersen, Monica L ; Tufik, Sergio ; Frussa-Filho, Roberto</creatorcontrib><description>Abstract Background Behavioral sensitization in rodents is hypothesized to reflect neuronal adaptations that are related to drug addiction in humans. We evaluated the effects of group exposure on the acute hyperlocomotion and behavioral sensitization induced by four drugs of abuse in C57BL/6 mice: methylenedioxymethamphetamine (MDMA), d-amphetamine, morphine and ethanol. Methods In the priming session, animals received an ip injection of one of the drugs of abuse and were exposed to an open field either individually or in groups of four. Seven days later, we assessed behavioral sensitization in the challenge session. All animals received an ip injection of the same drug and were exposed to the open field in the same social conditions described for the priming session. Locomotion and social interaction were quantified during each session. Results Acute MDMA, morphine and ethanol, but not d-amphetamine, increased social interaction. However, group exposure only potentiated MDMA-induced hyperlocomotion. After a challenge injection of each drug, there was no sensitization to the facilitating effect of MDMA, morphine or ethanol on social interaction, but locomotion sensitization developed to all drugs of abuse except ethanol. This sensitization was potentiated by group exposure in MDMA-treated animals, attenuated in morphine-treated animals and not modified in d-amphetamine-treated animals. Acute MDMA enhanced body contact and peaceful following, while acute morphine and ethanol increased social sniffing. Conclusions These results provide preclinical evidence showing that while different drugs of abuse affect different components of social interaction, the neuronal adaptations related to drug dependence can be critically and specifically influenced by group exposure.</description><identifier>ISSN: 0376-8716</identifier><identifier>EISSN: 1879-0046</identifier><identifier>DOI: 10.1016/j.drugalcdep.2011.04.017</identifier><identifier>PMID: 21596493</identifier><identifier>CODEN: DADEDV</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Addictive behaviors ; Adult and adolescent clinical studies ; Animals ; Behavior, Animal - drug effects ; Behavioral sensitization ; Biological and medical sciences ; Central Nervous System Sensitization - drug effects ; Central Nervous System Stimulants - pharmacology ; Dextroamphetamine - pharmacology ; Drug addiction ; Drugs of abuse ; Ecstasy drug ; Ethanol - pharmacology ; Ethyl alcohol ; Group exposure ; Hyperkinesis - chemically induced ; Hyperlocomotion ; Injections ; Male ; Medical sciences ; Mice ; Morphine ; Morphine - pharmacology ; Motor Activity - drug effects ; N-Methyl-3,4-methylenedioxyamphetamine - pharmacology ; Narcotics - pharmacology ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Sensitization ; Social Behavior ; Social interaction ; Substance abuse</subject><ispartof>Drug and alcohol dependence, 2011-11, Vol.118 (2), p.349-359</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2011 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-f9c8a0bf4e503f69a274d35dd7394c005fc2d31309ec60f562a01f3fd2c59b803</citedby><cites>FETCH-LOGICAL-c492t-f9c8a0bf4e503f69a274d35dd7394c005fc2d31309ec60f562a01f3fd2c59b803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S037687161100189X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,30977,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24624098$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21596493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Procópio-Souza, Roberta</creatorcontrib><creatorcontrib>Fukushiro, Daniela F</creatorcontrib><creatorcontrib>Trombin, Thaís F</creatorcontrib><creatorcontrib>Wuo-Silva, Raphael</creatorcontrib><creatorcontrib>Zanlorenci, Lineane H.F</creatorcontrib><creatorcontrib>Lima, Alexandre J.O</creatorcontrib><creatorcontrib>Ribeiro, Luciana T.C</creatorcontrib><creatorcontrib>Corrêa, Jussara M.R.M</creatorcontrib><creatorcontrib>Marinho, Eduardo A.V</creatorcontrib><creatorcontrib>Kameda, Sonia R</creatorcontrib><creatorcontrib>Andersen, Monica L</creatorcontrib><creatorcontrib>Tufik, Sergio</creatorcontrib><creatorcontrib>Frussa-Filho, Roberto</creatorcontrib><title>Effects of group exposure on single injection-induced behavioral sensitization to drugs of abuse in mice</title><title>Drug and alcohol dependence</title><addtitle>Drug Alcohol Depend</addtitle><description>Abstract Background Behavioral sensitization in rodents is hypothesized to reflect neuronal adaptations that are related to drug addiction in humans. We evaluated the effects of group exposure on the acute hyperlocomotion and behavioral sensitization induced by four drugs of abuse in C57BL/6 mice: methylenedioxymethamphetamine (MDMA), d-amphetamine, morphine and ethanol. Methods In the priming session, animals received an ip injection of one of the drugs of abuse and were exposed to an open field either individually or in groups of four. Seven days later, we assessed behavioral sensitization in the challenge session. All animals received an ip injection of the same drug and were exposed to the open field in the same social conditions described for the priming session. Locomotion and social interaction were quantified during each session. Results Acute MDMA, morphine and ethanol, but not d-amphetamine, increased social interaction. However, group exposure only potentiated MDMA-induced hyperlocomotion. After a challenge injection of each drug, there was no sensitization to the facilitating effect of MDMA, morphine or ethanol on social interaction, but locomotion sensitization developed to all drugs of abuse except ethanol. This sensitization was potentiated by group exposure in MDMA-treated animals, attenuated in morphine-treated animals and not modified in d-amphetamine-treated animals. Acute MDMA enhanced body contact and peaceful following, while acute morphine and ethanol increased social sniffing. Conclusions These results provide preclinical evidence showing that while different drugs of abuse affect different components of social interaction, the neuronal adaptations related to drug dependence can be critically and specifically influenced by group exposure.</description><subject>Addictive behaviors</subject><subject>Adult and adolescent clinical studies</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavioral sensitization</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System Sensitization - drug effects</subject><subject>Central Nervous System Stimulants - pharmacology</subject><subject>Dextroamphetamine - pharmacology</subject><subject>Drug addiction</subject><subject>Drugs of abuse</subject><subject>Ecstasy drug</subject><subject>Ethanol - pharmacology</subject><subject>Ethyl alcohol</subject><subject>Group exposure</subject><subject>Hyperkinesis - chemically induced</subject><subject>Hyperlocomotion</subject><subject>Injections</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Morphine</subject><subject>Morphine - pharmacology</subject><subject>Motor Activity - drug effects</subject><subject>N-Methyl-3,4-methylenedioxyamphetamine - pharmacology</subject><subject>Narcotics - pharmacology</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Sensitization</subject><subject>Social Behavior</subject><subject>Social interaction</subject><subject>Substance abuse</subject><issn>0376-8716</issn><issn>1879-0046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkk2LFDEQhhtR3HH1L0gugpduKx-d7lwEXdYPWPCggreQSSqzGXuSMZleXH-9aWd0wYvmkstTbxX1VNMQCh0FKl9sO5fnjZmsw33HgNIORAd0uNes6DioFkDI-80K-CDbcaDyrHlUyhbqkwoeNmeM9koKxVfN9aX3aA-FJE82Oc17gt_3qcwZSYqkhLiZkIS4rUxIsQ3RzRYdWeO1uQkpm4kUjCUcwg-zAOSQyDLarzyznstSTHbB4uPmgTdTwSen_7z5_Oby08W79urD2_cXr65aKxQ7tF7Z0cDaC-yBe6kMG4TjvXMDV8IC9N4yxykHhVaC7yUzQD33jtlerUfg583zY-4-p28zloPehWJxmkzENBdNB0llz0ZK_43ynrGRgRIVHY-ozamUjF7vc9iZfKsp6EWJ3uo7JXpRokHoqqSWPj11mdc7dH8KfzuowLMTYIo1k88m2lDuOCGZADVW7vWRw7q-m4BZFxswVh0hVz3apfA_07z8K8ROIYba9yveYtmmOceqR1NdmAb9cTmh5YIoBaCj-sJ_Aha9xKw</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Procópio-Souza, Roberta</creator><creator>Fukushiro, Daniela F</creator><creator>Trombin, Thaís F</creator><creator>Wuo-Silva, Raphael</creator><creator>Zanlorenci, Lineane H.F</creator><creator>Lima, Alexandre J.O</creator><creator>Ribeiro, Luciana T.C</creator><creator>Corrêa, Jussara M.R.M</creator><creator>Marinho, Eduardo A.V</creator><creator>Kameda, Sonia R</creator><creator>Andersen, Monica L</creator><creator>Tufik, Sergio</creator><creator>Frussa-Filho, Roberto</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7QJ</scope></search><sort><creationdate>20111101</creationdate><title>Effects of group exposure on single injection-induced behavioral sensitization to drugs of abuse in mice</title><author>Procópio-Souza, Roberta ; Fukushiro, Daniela F ; Trombin, Thaís F ; Wuo-Silva, Raphael ; Zanlorenci, Lineane H.F ; Lima, Alexandre J.O ; Ribeiro, Luciana T.C ; Corrêa, Jussara M.R.M ; Marinho, Eduardo A.V ; Kameda, Sonia R ; Andersen, Monica L ; Tufik, Sergio ; Frussa-Filho, Roberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-f9c8a0bf4e503f69a274d35dd7394c005fc2d31309ec60f562a01f3fd2c59b803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Addictive behaviors</topic><topic>Adult and adolescent clinical studies</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavioral sensitization</topic><topic>Biological and medical sciences</topic><topic>Central Nervous System Sensitization - drug effects</topic><topic>Central Nervous System Stimulants - pharmacology</topic><topic>Dextroamphetamine - pharmacology</topic><topic>Drug addiction</topic><topic>Drugs of abuse</topic><topic>Ecstasy drug</topic><topic>Ethanol - pharmacology</topic><topic>Ethyl alcohol</topic><topic>Group exposure</topic><topic>Hyperkinesis - chemically induced</topic><topic>Hyperlocomotion</topic><topic>Injections</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Morphine</topic><topic>Morphine - pharmacology</topic><topic>Motor Activity - drug effects</topic><topic>N-Methyl-3,4-methylenedioxyamphetamine - pharmacology</topic><topic>Narcotics - pharmacology</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Sensitization</topic><topic>Social Behavior</topic><topic>Social interaction</topic><topic>Substance abuse</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Procópio-Souza, Roberta</creatorcontrib><creatorcontrib>Fukushiro, Daniela F</creatorcontrib><creatorcontrib>Trombin, Thaís F</creatorcontrib><creatorcontrib>Wuo-Silva, Raphael</creatorcontrib><creatorcontrib>Zanlorenci, Lineane H.F</creatorcontrib><creatorcontrib>Lima, Alexandre J.O</creatorcontrib><creatorcontrib>Ribeiro, Luciana T.C</creatorcontrib><creatorcontrib>Corrêa, Jussara M.R.M</creatorcontrib><creatorcontrib>Marinho, Eduardo A.V</creatorcontrib><creatorcontrib>Kameda, Sonia R</creatorcontrib><creatorcontrib>Andersen, Monica L</creatorcontrib><creatorcontrib>Tufik, Sergio</creatorcontrib><creatorcontrib>Frussa-Filho, Roberto</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>Drug and alcohol dependence</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Procópio-Souza, Roberta</au><au>Fukushiro, Daniela F</au><au>Trombin, Thaís F</au><au>Wuo-Silva, Raphael</au><au>Zanlorenci, Lineane H.F</au><au>Lima, Alexandre J.O</au><au>Ribeiro, Luciana T.C</au><au>Corrêa, Jussara M.R.M</au><au>Marinho, Eduardo A.V</au><au>Kameda, Sonia R</au><au>Andersen, Monica L</au><au>Tufik, Sergio</au><au>Frussa-Filho, Roberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of group exposure on single injection-induced behavioral sensitization to drugs of abuse in mice</atitle><jtitle>Drug and alcohol dependence</jtitle><addtitle>Drug Alcohol Depend</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>118</volume><issue>2</issue><spage>349</spage><epage>359</epage><pages>349-359</pages><issn>0376-8716</issn><eissn>1879-0046</eissn><coden>DADEDV</coden><abstract>Abstract Background Behavioral sensitization in rodents is hypothesized to reflect neuronal adaptations that are related to drug addiction in humans. We evaluated the effects of group exposure on the acute hyperlocomotion and behavioral sensitization induced by four drugs of abuse in C57BL/6 mice: methylenedioxymethamphetamine (MDMA), d-amphetamine, morphine and ethanol. Methods In the priming session, animals received an ip injection of one of the drugs of abuse and were exposed to an open field either individually or in groups of four. Seven days later, we assessed behavioral sensitization in the challenge session. All animals received an ip injection of the same drug and were exposed to the open field in the same social conditions described for the priming session. Locomotion and social interaction were quantified during each session. Results Acute MDMA, morphine and ethanol, but not d-amphetamine, increased social interaction. However, group exposure only potentiated MDMA-induced hyperlocomotion. After a challenge injection of each drug, there was no sensitization to the facilitating effect of MDMA, morphine or ethanol on social interaction, but locomotion sensitization developed to all drugs of abuse except ethanol. This sensitization was potentiated by group exposure in MDMA-treated animals, attenuated in morphine-treated animals and not modified in d-amphetamine-treated animals. Acute MDMA enhanced body contact and peaceful following, while acute morphine and ethanol increased social sniffing. Conclusions These results provide preclinical evidence showing that while different drugs of abuse affect different components of social interaction, the neuronal adaptations related to drug dependence can be critically and specifically influenced by group exposure.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>21596493</pmid><doi>10.1016/j.drugalcdep.2011.04.017</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0376-8716 |
| ispartof | Drug and alcohol dependence, 2011-11, Vol.118 (2), p.349-359 |
| issn | 0376-8716 1879-0046 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1761652811 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Addictive behaviors Adult and adolescent clinical studies Animals Behavior, Animal - drug effects Behavioral sensitization Biological and medical sciences Central Nervous System Sensitization - drug effects Central Nervous System Stimulants - pharmacology Dextroamphetamine - pharmacology Drug addiction Drugs of abuse Ecstasy drug Ethanol - pharmacology Ethyl alcohol Group exposure Hyperkinesis - chemically induced Hyperlocomotion Injections Male Medical sciences Mice Morphine Morphine - pharmacology Motor Activity - drug effects N-Methyl-3,4-methylenedioxyamphetamine - pharmacology Narcotics - pharmacology Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Sensitization Social Behavior Social interaction Substance abuse |
| title | Effects of group exposure on single injection-induced behavioral sensitization to drugs of abuse in mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T23%3A00%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20group%20exposure%20on%20single%20injection-induced%20behavioral%20sensitization%20to%20drugs%20of%20abuse%20in%20mice&rft.jtitle=Drug%20and%20alcohol%20dependence&rft.au=Proc%C3%B3pio-Souza,%20Roberta&rft.date=2011-11-01&rft.volume=118&rft.issue=2&rft.spage=349&rft.epage=359&rft.pages=349-359&rft.issn=0376-8716&rft.eissn=1879-0046&rft.coden=DADEDV&rft_id=info:doi/10.1016/j.drugalcdep.2011.04.017&rft_dat=%3Cproquest_cross%3E1761652811%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1352282094&rft_id=info:pmid/21596493&rft_els_id=S037687161100189X&rfr_iscdi=true |