EBV-Positive and EBV-Negative Posttransplant Diffuse Large B Cell Lymphomas Have Distinct Genomic and Transcriptomic Features

The molecular pathogenesis of posttransplant diffuse large B cell lymphoma (PT-DLBCL) is largely unknown. We have recently shown that Epstein-Barr virus–positive (EBV+) and –negative (EBV−) PT-DLBCL have distinct gene expression profiles, and the transcriptomic profile of EBV− PT-DLBCL is similar to...

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Veröffentlicht in:	American journal of transplantation 2016-02, Vol.16 (2), p.414-425
Hauptverfasser:	Finalet Ferreiro, J., Morscio, J., Dierickx, D., Vandenberghe, P., Gheysens, O., Verhoef, G., Zamani, M., Tousseyn, T., Wlodarska, I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over B-cell lymphoma Biomarkers, Tumor - genetics Case-Control Studies Child Child, Preschool Comparative Genomic Hybridization Epstein-Barr virus Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - genetics Epstein-Barr Virus Infections - virology Female Follow-Up Studies Foxp1 protein Gene expression Gene Expression Profiling Genomics Genomics - methods Graft Rejection Graft Survival Herpesvirus 4, Human Humans Hybridization Immunoenzyme Techniques In Situ Hybridization Lymphoma Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - surgery Lymphoma, Large B-Cell, Diffuse - virology Male Middle Aged Pathogenesis Postoperative Complications - genetics Prognosis Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Transcriptomics Transplants & implants Tumor suppressor genes Young Adult
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