Significance of single lung transplantation in the current situation of severe donor shortage in Japan
Objective Although bilateral lung transplantation is the procedure of choice internationally, single lung transplantation is preferred in Japan because of the severe donor shortage except in cases of contraindications to single lung transplantation. This study aimed to evaluate the clinical characte...
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| Veröffentlicht in: | General thoracic and cardiovascular surgery 2016-02, Vol.64 (2), p.93-97 |
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| creator | Miyoshi, Ryo Chen-Yoshikawa, Toyofumi F. Hijiya, Kyoko Motoyama, Hideki Aoyama, Akihiro Menju, Toshi Sato, Toshihiko Sonobe, Makoto Date, Hiroshi |
| description | Objective
Although bilateral lung transplantation is the procedure of choice internationally, single lung transplantation is preferred in Japan because of the severe donor shortage except in cases of contraindications to single lung transplantation. This study aimed to evaluate the clinical characteristics of single lung transplant recipients and outcomes of this procedure at one of the largest lung transplant centers in Japan.
Methods
Between April 2002 and May 2015, 57 cadaveric lung transplantations (33 single and 24 bilateral) were performed in Kyoto University Hospital. The clinical characteristics of the lung transplant recipients and outcomes of these procedures, including overall survival and postoperative complications, were investigated.
Results
Overall, the 1-, 3-, and 5-year survival rates were 86, 77, and 72 %, respectively, with a median follow-up period of 1.9 years. There was no significant difference in survival between patients who underwent single lung transplantations and those who underwent bilateral lung transplantations (
p
= 0.92). The median waiting time was significantly shorter for single lung transplant patients than for bilateral lung transplant patients (
p
= 0.02). Native lung complications were seen in 14 out of 33 patients (42 %) who underwent single lung transplantation. There was no significant difference in survival between patients with and without postoperative native lung complications.
Conclusions
Single lung transplantation has been performed with acceptable outcomes in our institution. In the current situation of severe donor shortage in Japan, single lung transplantation can remain the first choice of treatment except in cases of contraindications to single lung transplantation. |
| doi_str_mv | 10.1007/s11748-015-0610-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1761471784</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2918739223</sourcerecordid><originalsourceid>FETCH-LOGICAL-c532t-8ee32f9cc93b98c36361d69c5540a07049faa6443ff604b9e5de944e2e0428cd3</originalsourceid><addsrcrecordid>eNp1kU1LHTEYhUOp1I_2B3QjATfdjOZ7kmURbS0XXGjXITfzZhyZm1yTTMF_7wxjLQhdJXCec_K-OQh9peScEtJeFEpboRtCZUMUJQ3_gI6oVrxRLeUf3-5EHqLjUh4JkUpT-QkdMqUYkVwfoXA39HEIg3fRA04BlyH2I-Bxij2u2cWyH12srg4p4iHi-gDYTzlDrDNap1VYfPAHMuAuxZRxeUi5uh4Wxy-3d_EzOghuLPDl9TxBv6-v7i9_NpvbHzeX3zeNl5zVRgNwFoz3hm-N9lxxRTtlvJSCONISYYJzSggegiJia0B2YIQABkQw7Tt-gr6tufucniYo1e6G4mGcd4A0FUtbRUVLWy1m9Owd-pimHOfpLDNUt9wwxmeKrpTPqZQMwe7zsHP52VJilxLsWoKdS7BLCXbxnL4mT9sddG-Ov78-A2wFyizFHvK_p_-f-gK1XJIa</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2918739223</pqid></control><display><type>article</type><title>Significance of single lung transplantation in the current situation of severe donor shortage in Japan</title><source>MEDLINE</source><source>ProQuest Central (Alumni Edition)</source><source>ProQuest Central UK/Ireland</source><source>SpringerLink Journals - AutoHoldings</source><source>ProQuest Central</source><creator>Miyoshi, Ryo ; Chen-Yoshikawa, Toyofumi F. ; Hijiya, Kyoko ; Motoyama, Hideki ; Aoyama, Akihiro ; Menju, Toshi ; Sato, Toshihiko ; Sonobe, Makoto ; Date, Hiroshi</creator><creatorcontrib>Miyoshi, Ryo ; Chen-Yoshikawa, Toyofumi F. ; Hijiya, Kyoko ; Motoyama, Hideki ; Aoyama, Akihiro ; Menju, Toshi ; Sato, Toshihiko ; Sonobe, Makoto ; Date, Hiroshi</creatorcontrib><description>Objective
Although bilateral lung transplantation is the procedure of choice internationally, single lung transplantation is preferred in Japan because of the severe donor shortage except in cases of contraindications to single lung transplantation. This study aimed to evaluate the clinical characteristics of single lung transplant recipients and outcomes of this procedure at one of the largest lung transplant centers in Japan.
Methods
Between April 2002 and May 2015, 57 cadaveric lung transplantations (33 single and 24 bilateral) were performed in Kyoto University Hospital. The clinical characteristics of the lung transplant recipients and outcomes of these procedures, including overall survival and postoperative complications, were investigated.
Results
Overall, the 1-, 3-, and 5-year survival rates were 86, 77, and 72 %, respectively, with a median follow-up period of 1.9 years. There was no significant difference in survival between patients who underwent single lung transplantations and those who underwent bilateral lung transplantations (
p
= 0.92). The median waiting time was significantly shorter for single lung transplant patients than for bilateral lung transplant patients (
p
= 0.02). Native lung complications were seen in 14 out of 33 patients (42 %) who underwent single lung transplantation. There was no significant difference in survival between patients with and without postoperative native lung complications.
Conclusions
Single lung transplantation has been performed with acceptable outcomes in our institution. In the current situation of severe donor shortage in Japan, single lung transplantation can remain the first choice of treatment except in cases of contraindications to single lung transplantation.</description><identifier>ISSN: 1863-6705</identifier><identifier>EISSN: 1863-6713</identifier><identifier>DOI: 10.1007/s11748-015-0610-3</identifier><identifier>PMID: 26620538</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adolescent ; Adult ; Autoimmune diseases ; Blood & organ donations ; Body mass index ; Cardiac Surgery ; Cardiology ; Child ; Chronic obstructive pulmonary disease ; Female ; Females ; Follow-Up Studies ; Humans ; Incidence ; Japan - epidemiology ; Lung diseases ; Lung Transplantation - methods ; Lung transplants ; Male ; Medical prognosis ; Medical treatment ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Patients ; Pneumonia ; Pneumothorax ; Postoperative Complications - epidemiology ; Retrospective Studies ; Stem cell transplantation ; Surgery ; Surgical Oncology ; Survival Rate - trends ; Thoracic Surgery ; Time Factors ; Tissue Donors - supply & distribution ; Tomography ; Waiting Lists - mortality ; Young Adult</subject><ispartof>General thoracic and cardiovascular surgery, 2016-02, Vol.64 (2), p.93-97</ispartof><rights>The Japanese Association for Thoracic Surgery 2015</rights><rights>The Japanese Association for Thoracic Surgery 2015.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-8ee32f9cc93b98c36361d69c5540a07049faa6443ff604b9e5de944e2e0428cd3</citedby><cites>FETCH-LOGICAL-c532t-8ee32f9cc93b98c36361d69c5540a07049faa6443ff604b9e5de944e2e0428cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11748-015-0610-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2918739223?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21388,21389,27924,27925,33530,33531,33744,33745,41488,42557,43659,43805,51319,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26620538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyoshi, Ryo</creatorcontrib><creatorcontrib>Chen-Yoshikawa, Toyofumi F.</creatorcontrib><creatorcontrib>Hijiya, Kyoko</creatorcontrib><creatorcontrib>Motoyama, Hideki</creatorcontrib><creatorcontrib>Aoyama, Akihiro</creatorcontrib><creatorcontrib>Menju, Toshi</creatorcontrib><creatorcontrib>Sato, Toshihiko</creatorcontrib><creatorcontrib>Sonobe, Makoto</creatorcontrib><creatorcontrib>Date, Hiroshi</creatorcontrib><title>Significance of single lung transplantation in the current situation of severe donor shortage in Japan</title><title>General thoracic and cardiovascular surgery</title><addtitle>Gen Thorac Cardiovasc Surg</addtitle><addtitle>Gen Thorac Cardiovasc Surg</addtitle><description>Objective
Although bilateral lung transplantation is the procedure of choice internationally, single lung transplantation is preferred in Japan because of the severe donor shortage except in cases of contraindications to single lung transplantation. This study aimed to evaluate the clinical characteristics of single lung transplant recipients and outcomes of this procedure at one of the largest lung transplant centers in Japan.
Methods
Between April 2002 and May 2015, 57 cadaveric lung transplantations (33 single and 24 bilateral) were performed in Kyoto University Hospital. The clinical characteristics of the lung transplant recipients and outcomes of these procedures, including overall survival and postoperative complications, were investigated.
Results
Overall, the 1-, 3-, and 5-year survival rates were 86, 77, and 72 %, respectively, with a median follow-up period of 1.9 years. There was no significant difference in survival between patients who underwent single lung transplantations and those who underwent bilateral lung transplantations (
p
= 0.92). The median waiting time was significantly shorter for single lung transplant patients than for bilateral lung transplant patients (
p
= 0.02). Native lung complications were seen in 14 out of 33 patients (42 %) who underwent single lung transplantation. There was no significant difference in survival between patients with and without postoperative native lung complications.
Conclusions
Single lung transplantation has been performed with acceptable outcomes in our institution. In the current situation of severe donor shortage in Japan, single lung transplantation can remain the first choice of treatment except in cases of contraindications to single lung transplantation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Autoimmune diseases</subject><subject>Blood & organ donations</subject><subject>Body mass index</subject><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Child</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Female</subject><subject>Females</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Incidence</subject><subject>Japan - epidemiology</subject><subject>Lung diseases</subject><subject>Lung Transplantation - methods</subject><subject>Lung transplants</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical treatment</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Patients</subject><subject>Pneumonia</subject><subject>Pneumothorax</subject><subject>Postoperative Complications - epidemiology</subject><subject>Retrospective Studies</subject><subject>Stem cell transplantation</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate - trends</subject><subject>Thoracic Surgery</subject><subject>Time Factors</subject><subject>Tissue Donors - supply & distribution</subject><subject>Tomography</subject><subject>Waiting Lists - mortality</subject><subject>Young Adult</subject><issn>1863-6705</issn><issn>1863-6713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kU1LHTEYhUOp1I_2B3QjATfdjOZ7kmURbS0XXGjXITfzZhyZm1yTTMF_7wxjLQhdJXCec_K-OQh9peScEtJeFEpboRtCZUMUJQ3_gI6oVrxRLeUf3-5EHqLjUh4JkUpT-QkdMqUYkVwfoXA39HEIg3fRA04BlyH2I-Bxij2u2cWyH12srg4p4iHi-gDYTzlDrDNap1VYfPAHMuAuxZRxeUi5uh4Wxy-3d_EzOghuLPDl9TxBv6-v7i9_NpvbHzeX3zeNl5zVRgNwFoz3hm-N9lxxRTtlvJSCONISYYJzSggegiJia0B2YIQABkQw7Tt-gr6tufucniYo1e6G4mGcd4A0FUtbRUVLWy1m9Owd-pimHOfpLDNUt9wwxmeKrpTPqZQMwe7zsHP52VJilxLsWoKdS7BLCXbxnL4mT9sddG-Ov78-A2wFyizFHvK_p_-f-gK1XJIa</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Miyoshi, Ryo</creator><creator>Chen-Yoshikawa, Toyofumi F.</creator><creator>Hijiya, Kyoko</creator><creator>Motoyama, Hideki</creator><creator>Aoyama, Akihiro</creator><creator>Menju, Toshi</creator><creator>Sato, Toshihiko</creator><creator>Sonobe, Makoto</creator><creator>Date, Hiroshi</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20160201</creationdate><title>Significance of single lung transplantation in the current situation of severe donor shortage in Japan</title><author>Miyoshi, Ryo ; Chen-Yoshikawa, Toyofumi F. ; Hijiya, Kyoko ; Motoyama, Hideki ; Aoyama, Akihiro ; Menju, Toshi ; Sato, Toshihiko ; Sonobe, Makoto ; Date, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-8ee32f9cc93b98c36361d69c5540a07049faa6443ff604b9e5de944e2e0428cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Autoimmune diseases</topic><topic>Blood & organ donations</topic><topic>Body mass index</topic><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Child</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Female</topic><topic>Females</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Incidence</topic><topic>Japan - epidemiology</topic><topic>Lung diseases</topic><topic>Lung Transplantation - methods</topic><topic>Lung transplants</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical treatment</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Patients</topic><topic>Pneumonia</topic><topic>Pneumothorax</topic><topic>Postoperative Complications - epidemiology</topic><topic>Retrospective Studies</topic><topic>Stem cell transplantation</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate - trends</topic><topic>Thoracic Surgery</topic><topic>Time Factors</topic><topic>Tissue Donors - supply & distribution</topic><topic>Tomography</topic><topic>Waiting Lists - mortality</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyoshi, Ryo</creatorcontrib><creatorcontrib>Chen-Yoshikawa, Toyofumi F.</creatorcontrib><creatorcontrib>Hijiya, Kyoko</creatorcontrib><creatorcontrib>Motoyama, Hideki</creatorcontrib><creatorcontrib>Aoyama, Akihiro</creatorcontrib><creatorcontrib>Menju, Toshi</creatorcontrib><creatorcontrib>Sato, Toshihiko</creatorcontrib><creatorcontrib>Sonobe, Makoto</creatorcontrib><creatorcontrib>Date, Hiroshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>General thoracic and cardiovascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyoshi, Ryo</au><au>Chen-Yoshikawa, Toyofumi F.</au><au>Hijiya, Kyoko</au><au>Motoyama, Hideki</au><au>Aoyama, Akihiro</au><au>Menju, Toshi</au><au>Sato, Toshihiko</au><au>Sonobe, Makoto</au><au>Date, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of single lung transplantation in the current situation of severe donor shortage in Japan</atitle><jtitle>General thoracic and cardiovascular surgery</jtitle><stitle>Gen Thorac Cardiovasc Surg</stitle><addtitle>Gen Thorac Cardiovasc Surg</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>64</volume><issue>2</issue><spage>93</spage><epage>97</epage><pages>93-97</pages><issn>1863-6705</issn><eissn>1863-6713</eissn><abstract>Objective
Although bilateral lung transplantation is the procedure of choice internationally, single lung transplantation is preferred in Japan because of the severe donor shortage except in cases of contraindications to single lung transplantation. This study aimed to evaluate the clinical characteristics of single lung transplant recipients and outcomes of this procedure at one of the largest lung transplant centers in Japan.
Methods
Between April 2002 and May 2015, 57 cadaveric lung transplantations (33 single and 24 bilateral) were performed in Kyoto University Hospital. The clinical characteristics of the lung transplant recipients and outcomes of these procedures, including overall survival and postoperative complications, were investigated.
Results
Overall, the 1-, 3-, and 5-year survival rates were 86, 77, and 72 %, respectively, with a median follow-up period of 1.9 years. There was no significant difference in survival between patients who underwent single lung transplantations and those who underwent bilateral lung transplantations (
p
= 0.92). The median waiting time was significantly shorter for single lung transplant patients than for bilateral lung transplant patients (
p
= 0.02). Native lung complications were seen in 14 out of 33 patients (42 %) who underwent single lung transplantation. There was no significant difference in survival between patients with and without postoperative native lung complications.
Conclusions
Single lung transplantation has been performed with acceptable outcomes in our institution. In the current situation of severe donor shortage in Japan, single lung transplantation can remain the first choice of treatment except in cases of contraindications to single lung transplantation.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>26620538</pmid><doi>10.1007/s11748-015-0610-3</doi><tpages>5</tpages></addata></record> |
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| ispartof | General thoracic and cardiovascular surgery, 2016-02, Vol.64 (2), p.93-97 |
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| source | MEDLINE; ProQuest Central (Alumni Edition); ProQuest Central UK/Ireland; SpringerLink Journals - AutoHoldings; ProQuest Central |
| subjects | Adolescent Adult Autoimmune diseases Blood & organ donations Body mass index Cardiac Surgery Cardiology Child Chronic obstructive pulmonary disease Female Females Follow-Up Studies Humans Incidence Japan - epidemiology Lung diseases Lung Transplantation - methods Lung transplants Male Medical prognosis Medical treatment Medicine Medicine & Public Health Middle Aged Original Article Patients Pneumonia Pneumothorax Postoperative Complications - epidemiology Retrospective Studies Stem cell transplantation Surgery Surgical Oncology Survival Rate - trends Thoracic Surgery Time Factors Tissue Donors - supply & distribution Tomography Waiting Lists - mortality Young Adult |
| title | Significance of single lung transplantation in the current situation of severe donor shortage in Japan |
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