Post-translational Control of the Temporal Dynamics of Transcription Factor Activity Regulates Neurogenesis

Neurogenesis is initiated by the transient expression of the highly conserved proneural proteins, bHLH transcriptional regulators. Here, we discover a conserved post-translational switch governing the duration of proneural protein activity that is required for proper neuronal development. Phosphoryl...

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Veröffentlicht in:	Cell 2016-01, Vol.164 (3), p.460-475
Hauptverfasser:	Quan, Xiao-Jiang, Yuan, Liqun, Tiberi, Luca, Claeys, Annelies, De Geest, Natalie, Yan, Jiekun, van der Kant, Rob, Xie, Wei R., Klisch, Tiemo J., Shymkowitz, Joost, Rousseau, Frederic, Bollen, Mathieu, Beullens, Monique, Zoghbi, Huda Y., Vanderhaeghen, Pierre, Hassan, Bassem A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Basic Helix-Loop-Helix Transcription Factors - chemistry Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Drosophila Drosophila Proteins Eye - growth & development Eye - ultrastructure Imaginal Discs - metabolism Mice Models, Molecular Molecular Sequence Data Nerve Tissue Proteins - metabolism Neurogenesis Phosphorylation Retina - growth & development Sequence Alignment
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