Performance Assessment of a Newly Developed Rapid Diagnostic Reagent for Human Immunodeficiency Virus
Extremely early diagnosis of human immunodeficiency virus (HIV) infection has been considered highly important for its treatment. We conducted a performance assessment of a newly developed rapid diagnostic reagent for HIV by using a fourth-generation immunochromatographic assay (Alere HIV Combo). We...
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| Veröffentlicht in: | Kansenshogaku Zasshi 2015/11/20, Vol.89(6), pp.733-740 |
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| container_title | Kansenshogaku Zasshi |
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| creator | NAKAGIRI, Itsuhiro WADA, Hideho TOKUNAGA, Hirotoshi FUKUDA, Hirofumi TASAKA, Taizo SUGIHARA, Takashi |
| description | Extremely early diagnosis of human immunodeficiency virus (HIV) infection has been considered highly important for its treatment. We conducted a performance assessment of a newly developed rapid diagnostic reagent for HIV by using a fourth-generation immunochromatographic assay (Alere HIV Combo). We used whole-blood, plasma, and serum samples obtained from 250 Japanese adults who visited the Kawasaki Medical School Hospital and underwent HIV screening tests. We also used 12 types of commercial HIV-1 seroconversion panels and World Health Organization standard antigens. This method, which has a detection sensitivity of 100% and a specificity of 99.3%, was as accurate as the chemiluminescent immunoassay (CLIA) method. In a sensitivity test using seroconversion panels in the early phase of infection, the mean duration until positive conversion was 19.3 days. With this method having a high detection sensitivity for HIV-1p24 antigen, the results from whole-blood samples were the same as those from plasma and serum samples. Therefore, it can be considered as a useful rapid measurement method for general practice. |
| doi_str_mv | 10.11150/kansenshogakuzasshi.89.733 |
| format | Article |
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With this method having a high detection sensitivity for HIV-1p24 antigen, the results from whole-blood samples were the same as those from plasma and serum samples. 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| ispartof | Kansenshogaku Zasshi, 2015/11/20, Vol.89(6), pp.733-740 |
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| language | eng ; jpn |
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| subjects | Adult Chromatography, Affinity - methods HIV Antibodies - immunology HIV Antigens - analysis HIV Infections - diagnosis HIV screening tests HIV-1 - immunology HIV-1 - isolation & purification HIV-1p24 antigen Humans immunochromatographic assay Middle Aged whole-blood sample |
| title | Performance Assessment of a Newly Developed Rapid Diagnostic Reagent for Human Immunodeficiency Virus |
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