How to improve the prevention of chemotherapy-induced nausea and vomiting? The French NAVI study

Purpose Chemotherapy-induced nausea and vomiting (CINV) still remain frequent. The procedure for announcing the diagnosis (PAD) was an emblematic measure of the first French Plan Cancer aiming at providing patients with time to listen, information after cancer diagnosis, and discussion on treatments...

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Veröffentlicht in:Supportive care in cancer 2016-03, Vol.24 (3), p.1131-1138
Hauptverfasser: Vanbockstael, Julie, Coquan, Elodie, Gouerant, Sophie, Allouache, Djelila, Faveyrial, Audrey, Noal, Sabine, Delcambre, Corinne, Galais, Marie-Pierre, Héron, Jean-François, Lefebvre, Anne-Charlotte, Sevin, Emmanuel, Hrab, Ioana, Polycarpe, Florence, André, Michel, Kaluzinski, Laure, Gervais, Radj, Gunzer, Katharina, Vié, Brigitte, Saucier, Gilles, Lemenand, Noëmie, Grellard, Jean-Michel, Clarisse, Bénédicte, Dugué, Audrey Emmanuelle, Joly, Florence
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container_end_page 1138
container_issue 3
container_start_page 1131
container_title Supportive care in cancer
container_volume 24
creator Vanbockstael, Julie
Coquan, Elodie
Gouerant, Sophie
Allouache, Djelila
Faveyrial, Audrey
Noal, Sabine
Delcambre, Corinne
Galais, Marie-Pierre
Héron, Jean-François
Lefebvre, Anne-Charlotte
Sevin, Emmanuel
Hrab, Ioana
Polycarpe, Florence
André, Michel
Kaluzinski, Laure
Gervais, Radj
Gunzer, Katharina
Vié, Brigitte
Saucier, Gilles
Lemenand, Noëmie
Grellard, Jean-Michel
Clarisse, Bénédicte
Dugué, Audrey Emmanuelle
Joly, Florence
description Purpose Chemotherapy-induced nausea and vomiting (CINV) still remain frequent. The procedure for announcing the diagnosis (PAD) was an emblematic measure of the first French Plan Cancer aiming at providing patients with time to listen, information after cancer diagnosis, and discussion on treatments and their side effects. We aimed at assessing the risk factors of CINV, focusing on patients’ satisfaction with the PAD. Methods This prospective multicentre study assessed the frequency and intensity of CINV among chemonaïve patients during the first cycle of treatment. CINV was defined by ≥1 emetic episode or reported nausea intensity ≥3 on a 0–10 scale. Multivariate analysis was used to identify factors related to global CINV onset including satisfaction with the PAD (satisfaction score ≥the median on a 0–10 scale). Results Data from 291 patients (women, 85.2 %; mean age, 57 years) were analyzed. Most patients (69.4 %) received highly emetogenic chemotherapy regimens and 77.7 % received antiemetic drugs consistent with international guidelines. Acute, delayed and overall CINV were experienced by 40.4, 34.8 and 52.4 % of patients, respectively. Sixty-seven per cent of patients were satisfied with the PAD. No relation was noted between PAD satisfaction and CINV onset. The nausea and vomiting dimension of the QLQ-C30 questionnaire before chemotherapy (OR 3.62), motion sickness history (OR 2.73), highly emetogenic CT (OR 2.73), anxiety (OR 1.99) and younger age (OR 1.96) were independent predictive factors. Conclusions Although patients were mostly satisfied with the PAD, half of them experienced CINV. A state of anxiety could be identified during the PAD to be managed.
doi_str_mv 10.1007/s00520-015-2882-7
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The French NAVI study</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Vanbockstael, Julie ; Coquan, Elodie ; Gouerant, Sophie ; Allouache, Djelila ; Faveyrial, Audrey ; Noal, Sabine ; Delcambre, Corinne ; Galais, Marie-Pierre ; Héron, Jean-François ; Lefebvre, Anne-Charlotte ; Sevin, Emmanuel ; Hrab, Ioana ; Polycarpe, Florence ; André, Michel ; Kaluzinski, Laure ; Gervais, Radj ; Gunzer, Katharina ; Vié, Brigitte ; Saucier, Gilles ; Lemenand, Noëmie ; Grellard, Jean-Michel ; Clarisse, Bénédicte ; Dugué, Audrey Emmanuelle ; Joly, Florence</creator><creatorcontrib>Vanbockstael, Julie ; Coquan, Elodie ; Gouerant, Sophie ; Allouache, Djelila ; Faveyrial, Audrey ; Noal, Sabine ; Delcambre, Corinne ; Galais, Marie-Pierre ; Héron, Jean-François ; Lefebvre, Anne-Charlotte ; Sevin, Emmanuel ; Hrab, Ioana ; Polycarpe, Florence ; André, Michel ; Kaluzinski, Laure ; Gervais, Radj ; Gunzer, Katharina ; Vié, Brigitte ; Saucier, Gilles ; Lemenand, Noëmie ; Grellard, Jean-Michel ; Clarisse, Bénédicte ; Dugué, Audrey Emmanuelle ; Joly, Florence</creatorcontrib><description>Purpose Chemotherapy-induced nausea and vomiting (CINV) still remain frequent. The procedure for announcing the diagnosis (PAD) was an emblematic measure of the first French Plan Cancer aiming at providing patients with time to listen, information after cancer diagnosis, and discussion on treatments and their side effects. We aimed at assessing the risk factors of CINV, focusing on patients’ satisfaction with the PAD. Methods This prospective multicentre study assessed the frequency and intensity of CINV among chemonaïve patients during the first cycle of treatment. CINV was defined by ≥1 emetic episode or reported nausea intensity ≥3 on a 0–10 scale. Multivariate analysis was used to identify factors related to global CINV onset including satisfaction with the PAD (satisfaction score ≥the median on a 0–10 scale). Results Data from 291 patients (women, 85.2 %; mean age, 57 years) were analyzed. Most patients (69.4 %) received highly emetogenic chemotherapy regimens and 77.7 % received antiemetic drugs consistent with international guidelines. Acute, delayed and overall CINV were experienced by 40.4, 34.8 and 52.4 % of patients, respectively. Sixty-seven per cent of patients were satisfied with the PAD. No relation was noted between PAD satisfaction and CINV onset. The nausea and vomiting dimension of the QLQ-C30 questionnaire before chemotherapy (OR 3.62), motion sickness history (OR 2.73), highly emetogenic CT (OR 2.73), anxiety (OR 1.99) and younger age (OR 1.96) were independent predictive factors. Conclusions Although patients were mostly satisfied with the PAD, half of them experienced CINV. A state of anxiety could be identified during the PAD to be managed.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-015-2882-7</identifier><identifier>PMID: 26268784</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analysis ; Antiemetics - therapeutic use ; Antineoplastic Agents - adverse effects ; Cancer ; Care and treatment ; Chemotherapy ; Female ; France ; Gastrointestinal agents ; Humans ; Male ; Medicine ; Medicine &amp; Public Health ; Methods ; Middle Aged ; Nausea ; Nausea - chemically induced ; Nausea - prevention &amp; control ; Neoplasms - complications ; Neoplasms - drug therapy ; Nursing ; Nursing Research ; Oncology ; Original Article ; Pain Medicine ; Prevention ; Prospective Studies ; Rehabilitation Medicine ; Studies ; Vomiting ; Vomiting - chemically induced ; Vomiting - prevention &amp; control</subject><ispartof>Supportive care in cancer, 2016-03, Vol.24 (3), p.1131-1138</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><rights>COPYRIGHT 2016 Springer</rights><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c575t-848c0f8094f433bb8575c893c426b4c46805f835c8a85260dfa988ca7cd988353</citedby><cites>FETCH-LOGICAL-c575t-848c0f8094f433bb8575c893c426b4c46805f835c8a85260dfa988ca7cd988353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-015-2882-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-015-2882-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26268784$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vanbockstael, Julie</creatorcontrib><creatorcontrib>Coquan, Elodie</creatorcontrib><creatorcontrib>Gouerant, Sophie</creatorcontrib><creatorcontrib>Allouache, Djelila</creatorcontrib><creatorcontrib>Faveyrial, Audrey</creatorcontrib><creatorcontrib>Noal, Sabine</creatorcontrib><creatorcontrib>Delcambre, Corinne</creatorcontrib><creatorcontrib>Galais, Marie-Pierre</creatorcontrib><creatorcontrib>Héron, Jean-François</creatorcontrib><creatorcontrib>Lefebvre, Anne-Charlotte</creatorcontrib><creatorcontrib>Sevin, Emmanuel</creatorcontrib><creatorcontrib>Hrab, Ioana</creatorcontrib><creatorcontrib>Polycarpe, Florence</creatorcontrib><creatorcontrib>André, Michel</creatorcontrib><creatorcontrib>Kaluzinski, Laure</creatorcontrib><creatorcontrib>Gervais, Radj</creatorcontrib><creatorcontrib>Gunzer, Katharina</creatorcontrib><creatorcontrib>Vié, Brigitte</creatorcontrib><creatorcontrib>Saucier, Gilles</creatorcontrib><creatorcontrib>Lemenand, Noëmie</creatorcontrib><creatorcontrib>Grellard, Jean-Michel</creatorcontrib><creatorcontrib>Clarisse, Bénédicte</creatorcontrib><creatorcontrib>Dugué, Audrey Emmanuelle</creatorcontrib><creatorcontrib>Joly, Florence</creatorcontrib><title>How to improve the prevention of chemotherapy-induced nausea and vomiting? The French NAVI study</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Purpose Chemotherapy-induced nausea and vomiting (CINV) still remain frequent. The procedure for announcing the diagnosis (PAD) was an emblematic measure of the first French Plan Cancer aiming at providing patients with time to listen, information after cancer diagnosis, and discussion on treatments and their side effects. We aimed at assessing the risk factors of CINV, focusing on patients’ satisfaction with the PAD. Methods This prospective multicentre study assessed the frequency and intensity of CINV among chemonaïve patients during the first cycle of treatment. CINV was defined by ≥1 emetic episode or reported nausea intensity ≥3 on a 0–10 scale. Multivariate analysis was used to identify factors related to global CINV onset including satisfaction with the PAD (satisfaction score ≥the median on a 0–10 scale). Results Data from 291 patients (women, 85.2 %; mean age, 57 years) were analyzed. Most patients (69.4 %) received highly emetogenic chemotherapy regimens and 77.7 % received antiemetic drugs consistent with international guidelines. Acute, delayed and overall CINV were experienced by 40.4, 34.8 and 52.4 % of patients, respectively. Sixty-seven per cent of patients were satisfied with the PAD. No relation was noted between PAD satisfaction and CINV onset. The nausea and vomiting dimension of the QLQ-C30 questionnaire before chemotherapy (OR 3.62), motion sickness history (OR 2.73), highly emetogenic CT (OR 2.73), anxiety (OR 1.99) and younger age (OR 1.96) were independent predictive factors. Conclusions Although patients were mostly satisfied with the PAD, half of them experienced CINV. A state of anxiety could be identified during the PAD to be managed.</description><subject>Analysis</subject><subject>Antiemetics - therapeutic use</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Female</subject><subject>France</subject><subject>Gastrointestinal agents</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Nausea</subject><subject>Nausea - chemically induced</subject><subject>Nausea - prevention &amp; control</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - drug therapy</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Prevention</subject><subject>Prospective Studies</subject><subject>Rehabilitation Medicine</subject><subject>Studies</subject><subject>Vomiting</subject><subject>Vomiting - chemically induced</subject><subject>Vomiting - prevention &amp; control</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUtvEzEUhS0EomnhB7BBltiwcfFz7FmhqKK0UgWbwtY4njuJq4wd7JlU-fd4lJaXQF5c6fg796GD0CtGzxml-l2hVHFKKFOEG8OJfoIWTApBtBDtU7SgrWRECqVO0Gkpd5QyrRV_jk54wxujjVygb1fpHo8Jh2GX0x7wuAG8y7CHOIYUceqx38CQqpzd7kBC7CYPHY5uKuCwix3epyGMIa7f49vqvcwQ_QZ_Wn69xmWcusML9Kx32wIvH-oZ-nL54fbiitx8_nh9sbwhXmk1EiONp72pG_f1gNXKVNWbVnjJm5X0sjFU9UZUzRnFG9r1rjXGO-27WoUSZ-jtsW-94_sEZbRDKB62WxchTcUy3TDZyFa0FX3zF3qXphzrdjNFNRdcsF_U2m3BhtinMTs_N7VLKblpKVfz2PN_UPV1MASfIvSh6n8Y2NHgcyolQ293OQwuHyyjdk7VHlO1NVU7p2p19bx-WHhaDdD9dDzGWAF-BEr9imvIv130364_AIghqY0</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Vanbockstael, Julie</creator><creator>Coquan, Elodie</creator><creator>Gouerant, Sophie</creator><creator>Allouache, Djelila</creator><creator>Faveyrial, Audrey</creator><creator>Noal, Sabine</creator><creator>Delcambre, Corinne</creator><creator>Galais, Marie-Pierre</creator><creator>Héron, Jean-François</creator><creator>Lefebvre, Anne-Charlotte</creator><creator>Sevin, Emmanuel</creator><creator>Hrab, Ioana</creator><creator>Polycarpe, Florence</creator><creator>André, Michel</creator><creator>Kaluzinski, Laure</creator><creator>Gervais, Radj</creator><creator>Gunzer, Katharina</creator><creator>Vié, Brigitte</creator><creator>Saucier, Gilles</creator><creator>Lemenand, Noëmie</creator><creator>Grellard, Jean-Michel</creator><creator>Clarisse, Bénédicte</creator><creator>Dugué, Audrey Emmanuelle</creator><creator>Joly, Florence</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20160301</creationdate><title>How to improve the prevention of chemotherapy-induced nausea and vomiting? The French NAVI study</title><author>Vanbockstael, Julie ; Coquan, Elodie ; Gouerant, Sophie ; Allouache, Djelila ; Faveyrial, Audrey ; Noal, Sabine ; Delcambre, Corinne ; Galais, Marie-Pierre ; Héron, Jean-François ; Lefebvre, Anne-Charlotte ; Sevin, Emmanuel ; Hrab, Ioana ; Polycarpe, Florence ; André, Michel ; Kaluzinski, Laure ; Gervais, Radj ; Gunzer, Katharina ; Vié, Brigitte ; Saucier, Gilles ; Lemenand, Noëmie ; Grellard, Jean-Michel ; Clarisse, Bénédicte ; Dugué, Audrey Emmanuelle ; Joly, Florence</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c575t-848c0f8094f433bb8575c893c426b4c46805f835c8a85260dfa988ca7cd988353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Analysis</topic><topic>Antiemetics - therapeutic use</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Chemotherapy</topic><topic>Female</topic><topic>France</topic><topic>Gastrointestinal agents</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; 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The French NAVI study</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>24</volume><issue>3</issue><spage>1131</spage><epage>1138</epage><pages>1131-1138</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Purpose Chemotherapy-induced nausea and vomiting (CINV) still remain frequent. The procedure for announcing the diagnosis (PAD) was an emblematic measure of the first French Plan Cancer aiming at providing patients with time to listen, information after cancer diagnosis, and discussion on treatments and their side effects. We aimed at assessing the risk factors of CINV, focusing on patients’ satisfaction with the PAD. Methods This prospective multicentre study assessed the frequency and intensity of CINV among chemonaïve patients during the first cycle of treatment. CINV was defined by ≥1 emetic episode or reported nausea intensity ≥3 on a 0–10 scale. Multivariate analysis was used to identify factors related to global CINV onset including satisfaction with the PAD (satisfaction score ≥the median on a 0–10 scale). Results Data from 291 patients (women, 85.2 %; mean age, 57 years) were analyzed. Most patients (69.4 %) received highly emetogenic chemotherapy regimens and 77.7 % received antiemetic drugs consistent with international guidelines. Acute, delayed and overall CINV were experienced by 40.4, 34.8 and 52.4 % of patients, respectively. Sixty-seven per cent of patients were satisfied with the PAD. No relation was noted between PAD satisfaction and CINV onset. The nausea and vomiting dimension of the QLQ-C30 questionnaire before chemotherapy (OR 3.62), motion sickness history (OR 2.73), highly emetogenic CT (OR 2.73), anxiety (OR 1.99) and younger age (OR 1.96) were independent predictive factors. Conclusions Although patients were mostly satisfied with the PAD, half of them experienced CINV. A state of anxiety could be identified during the PAD to be managed.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26268784</pmid><doi>10.1007/s00520-015-2882-7</doi><tpages>8</tpages></addata></record>
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1433-7339
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source MEDLINE; SpringerLink Journals - AutoHoldings
subjects Analysis
Antiemetics - therapeutic use
Antineoplastic Agents - adverse effects
Cancer
Care and treatment
Chemotherapy
Female
France
Gastrointestinal agents
Humans
Male
Medicine
Medicine & Public Health
Methods
Middle Aged
Nausea
Nausea - chemically induced
Nausea - prevention & control
Neoplasms - complications
Neoplasms - drug therapy
Nursing
Nursing Research
Oncology
Original Article
Pain Medicine
Prevention
Prospective Studies
Rehabilitation Medicine
Studies
Vomiting
Vomiting - chemically induced
Vomiting - prevention & control
title How to improve the prevention of chemotherapy-induced nausea and vomiting? The French NAVI study
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