Different Effects of Tacrolimus on Innate and Adaptive Immune Cells in the Allograft Transplantation

While tacrolimus (FK506) is currently used as immunosuppression therapy in transplant recipient, the immunological mechanism remains unknown. Herein, the immunoregulatory effects of FK506 were investigated in the physiological status and allogeneic skin transplantation. FK506 cannot significantly al...

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Veröffentlicht in:	Scandinavian journal of immunology 2016-02, Vol.83 (2), p.119-127
Hauptverfasser:	Shao, K., Lu, Y., Wang, J., Chen, X., Zhang, Z., Wang, X., Yang, H., Liu, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity - drug effects Allografts - drug effects Allografts - immunology Animals Calcineurin Inhibitors - pharmacology Escherichia coli - immunology Female Graft Rejection - immunology Graft Rejection - prevention & control Graft Survival - drug effects Graft Survival - immunology Immunity, Innate - drug effects Immunosuppressive Agents - pharmacology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - immunology Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Models, Immunological Neutrophils - drug effects Neutrophils - immunology Phagocytosis - drug effects Phagocytosis - immunology Skin Transplantation T-Lymphocytes - drug effects T-Lymphocytes - immunology Tacrolimus - pharmacology Transplantation Tolerance - drug effects Transplantation Tolerance - immunology
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