Silencing overexpression of FXYD3 protein in breast cancer cells amplifies effects of doxorubicin and γ-radiation on Na+/K+-ATPase and cell survival

FXYD3, also known as mammary tumor protein 8, is overexpressed in several common cancers, including in many breast cancers. We examined if such overexpression might protect Na + /K + -ATPase and cancer cells against the high levels of oxidative stress characteristic of many tumors and often induced...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Breast cancer research and treatment 2016-01, Vol.155 (2), p.203-213
Hauptverfasser:	Liu, Chia-Chi, Teh, Rachel, Mozar, Christine A., Baxter, Robert C., Rasmussen, Helge H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Apoptosis - radiation effects Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - radiotherapy Cell Line, Tumor Cell Survival - drug effects Cell Survival - genetics Cell Survival - radiation effects Doxorubicin - pharmacology Female Gamma Rays - therapeutic use Gene Expression - drug effects Gene Expression - radiation effects Gene Silencing - drug effects Humans MCF-7 Cells Medicine Medicine & Public Health Membrane Proteins - genetics Neoplasm Proteins - genetics Oncology Preclinical Study Sodium-Potassium-Exchanging ATPase - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!