The role of miRNA in endometrial cancer in the context of miRNA 205

MiRNAs are small, non-coding molecules of ribonucleic acids of approximately 22 bp length, which serve as regulators of gene expression and protein translation due to interference with messenger RNA (mRNA). MiRNAs, which take part in the regulation of cell cycle and apoptosis, may be associated with...

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Veröffentlicht in:	Ginekologia polska 2015-11, Vol.86 (11), p.856-861
Hauptverfasser:	Wilczyński, Miłosz, Danielska, Justyna, Dzieniecka, Monika, Malinowski, Andrzej
Format:	Artikel
Sprache:	pol
Schlagworte:	Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cell Transformation, Neoplastic - genetics Endometrial Neoplasms - diagnosis Endometrial Neoplasms - genetics Endometrial Neoplasms - metabolism Female Gene Expression Regulation, Neoplastic Humans MicroRNAs - genetics Prognosis RNA, Messenger - genetics
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Beschreibung
Zusammenfassung:	MiRNAs are small, non-coding molecules of ribonucleic acids of approximately 22 bp length, which serve as regulators of gene expression and protein translation due to interference with messenger RNA (mRNA). MiRNAs, which take part in the regulation of cell cycle and apoptosis, may be associated with carcinogenesis. Aberrant expression of miRNAs in endometrial cancer might contribute to the endometrial cancer initiation or progression, as well as metastasis formation, and may influence cancer invasiveness. Specific-miRNAs expressed in endometrial cancer tissues may serve as diagnostic markers of the disease, prognostic biomarkers, or play an important part in oncological therapy We aimed to describe the role of miRNAs in endometrial cancer with special consideration of miRNA 205.
ISSN:	0017-0011