Multiple Ejaculations and Chronic Fluoxetine: Effects on Male Rat Copulatory Behavior
WIESELER FRANK, J. L., S. E. HENDRICKS AND C. H. OLSON. Multiple ejaculations and chronic fluoxetine: effects on male rat copulatory behavior. PHARMACOL BIOCHEM BEHAV 66(2) 337–342, 2000.—Male rats were treated with fluoxetine (FLX) or vehicle daily for 14 days and copulatory behavior tested on day...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 2000-06, Vol.66 (2), p.337-342 |
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| creator | Wieseler Frank, Julie L Hendricks, Shelton E Olson, Christian H |
| description | WIESELER FRANK, J. L., S. E. HENDRICKS AND C. H. OLSON.
Multiple ejaculations and chronic fluoxetine: effects on male rat copulatory behavior. PHARMACOL BIOCHEM BEHAV
66(2) 337–342, 2000.—Male rats were treated with fluoxetine (FLX) or vehicle daily for 14 days and copulatory behavior tested on day 15. Rats were either mated to three ejaculations or to sexual exhaustion. Both standard measures and the mount bout analysis were used to evaluate the effects of the chronic FLX on male rat copulatory behavior. Only 56.25% of the animals treated with FLX achieved three ejaculations. FLX inhibited the consumatory aspect of male sexual behavior, especially the ability to achieve three ejaculations, but there was no effect on the propensity of the male to pursue the female. These differences were observed for the first three ejaculations. Analysis of the last three ejaculations in those animals that mated to exhaustion did not reveal an effect of FLX. The behavioral pattern of FLX-treated animals during the first three ejaculations resembled that observed during the last three ejaculatory series in the vehicle-treated animals that mated to exhaustion. The results are discussed in terms of the serotonergic effects on male rat sexual behavior. |
| doi_str_mv | 10.1016/S0091-3057(00)00191-X |
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Multiple ejaculations and chronic fluoxetine: effects on male rat copulatory behavior. PHARMACOL BIOCHEM BEHAV
66(2) 337–342, 2000.—Male rats were treated with fluoxetine (FLX) or vehicle daily for 14 days and copulatory behavior tested on day 15. Rats were either mated to three ejaculations or to sexual exhaustion. Both standard measures and the mount bout analysis were used to evaluate the effects of the chronic FLX on male rat copulatory behavior. Only 56.25% of the animals treated with FLX achieved three ejaculations. FLX inhibited the consumatory aspect of male sexual behavior, especially the ability to achieve three ejaculations, but there was no effect on the propensity of the male to pursue the female. These differences were observed for the first three ejaculations. Analysis of the last three ejaculations in those animals that mated to exhaustion did not reveal an effect of FLX. The behavioral pattern of FLX-treated animals during the first three ejaculations resembled that observed during the last three ejaculatory series in the vehicle-treated animals that mated to exhaustion. The results are discussed in terms of the serotonergic effects on male rat sexual behavior.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/S0091-3057(00)00191-X</identifier><identifier>PMID: 10880687</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Appetitive Behavior - drug effects ; Appetitive Behavior - physiology ; Biological and medical sciences ; Consummatory Behavior - drug effects ; Consummatory Behavior - physiology ; Copulation - drug effects ; Copulation - physiology ; Dopamine - physiology ; Drug toxicity and drugs side effects treatment ; Ejaculation ; Ejaculation - drug effects ; Ejaculation - physiology ; Female ; Fluoxetine ; Fluoxetine - administration & dosage ; Fluoxetine - toxicity ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Rats ; Rats, Sprague-Dawley ; Serotonin ; Serotonin - physiology ; Serotonin Uptake Inhibitors - administration & dosage ; Serotonin Uptake Inhibitors - toxicity ; Sexual behavior ; Sexual Behavior, Animal - drug effects ; Sexual Behavior, Animal - physiology ; Toxicity: urogenital system</subject><ispartof>Pharmacology, biochemistry and behavior, 2000-06, Vol.66 (2), p.337-342</ispartof><rights>2000 Elsevier Science Inc.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-658a5b527ef1298ada52cbcf2f7c86eb00f89f7d375d9f488593a9448a7bae043</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S009130570000191X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1411702$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10880687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wieseler Frank, Julie L</creatorcontrib><creatorcontrib>Hendricks, Shelton E</creatorcontrib><creatorcontrib>Olson, Christian H</creatorcontrib><title>Multiple Ejaculations and Chronic Fluoxetine: Effects on Male Rat Copulatory Behavior</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>WIESELER FRANK, J. L., S. E. HENDRICKS AND C. H. OLSON.
Multiple ejaculations and chronic fluoxetine: effects on male rat copulatory behavior. PHARMACOL BIOCHEM BEHAV
66(2) 337–342, 2000.—Male rats were treated with fluoxetine (FLX) or vehicle daily for 14 days and copulatory behavior tested on day 15. Rats were either mated to three ejaculations or to sexual exhaustion. Both standard measures and the mount bout analysis were used to evaluate the effects of the chronic FLX on male rat copulatory behavior. Only 56.25% of the animals treated with FLX achieved three ejaculations. FLX inhibited the consumatory aspect of male sexual behavior, especially the ability to achieve three ejaculations, but there was no effect on the propensity of the male to pursue the female. These differences were observed for the first three ejaculations. Analysis of the last three ejaculations in those animals that mated to exhaustion did not reveal an effect of FLX. The behavioral pattern of FLX-treated animals during the first three ejaculations resembled that observed during the last three ejaculatory series in the vehicle-treated animals that mated to exhaustion. The results are discussed in terms of the serotonergic effects on male rat sexual behavior.</description><subject>Animals</subject><subject>Appetitive Behavior - drug effects</subject><subject>Appetitive Behavior - physiology</subject><subject>Biological and medical sciences</subject><subject>Consummatory Behavior - drug effects</subject><subject>Consummatory Behavior - physiology</subject><subject>Copulation - drug effects</subject><subject>Copulation - physiology</subject><subject>Dopamine - physiology</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Ejaculation</subject><subject>Ejaculation - drug effects</subject><subject>Ejaculation - physiology</subject><subject>Female</subject><subject>Fluoxetine</subject><subject>Fluoxetine - administration & dosage</subject><subject>Fluoxetine - toxicity</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Serotonin</subject><subject>Serotonin - physiology</subject><subject>Serotonin Uptake Inhibitors - administration & dosage</subject><subject>Serotonin Uptake Inhibitors - toxicity</subject><subject>Sexual behavior</subject><subject>Sexual Behavior, Animal - drug effects</subject><subject>Sexual Behavior, Animal - physiology</subject><subject>Toxicity: urogenital system</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0V1LHDEUBuAgFV2tP6ElF0X0YtqT-UrGG2mX9QOUQqvgXTiTOcHI7GRNZpb6783qtr0KB55zIO_L2CcBXwWI-ttvgEZkBVTyBOAUQKTpYYfNhJJFVgkpP7DZP7LPDmJ8AoAyr-Ue2xegFNRKztj97dSPbtUTXzyhmXocnR8ix6Hj88fgB2f4RT_5PzS6gc74wloyY-R-4LeYln7hyOd-tdnz4YX_oEdcOx8-sl2LfaSj7XvI7i8Wd_Or7Obn5fX8-01mClmNWV0prNoql2RF3ijssMpNa2xupVE1tQBWNVZ2CXeNLZWqmgKbslQoWyQoi0N2_H53FfzzRHHUSxcN9T0O5KeohaxFkecqwc9bOLVL6vQquCWGF_03iAS-bAFGg70NOBgX_7tSCAl5YufvjNKv1o6CjsbRYKhzIQWjO-_STb1pSL81pDfxawD91pB-KF4BUS-BpA</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>Wieseler Frank, Julie L</creator><creator>Hendricks, Shelton E</creator><creator>Olson, Christian H</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QG</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20000601</creationdate><title>Multiple Ejaculations and Chronic Fluoxetine: Effects on Male Rat Copulatory Behavior</title><author>Wieseler Frank, Julie L ; Hendricks, Shelton E ; Olson, Christian H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-658a5b527ef1298ada52cbcf2f7c86eb00f89f7d375d9f488593a9448a7bae043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Appetitive Behavior - drug effects</topic><topic>Appetitive Behavior - physiology</topic><topic>Biological and medical sciences</topic><topic>Consummatory Behavior - drug effects</topic><topic>Consummatory Behavior - physiology</topic><topic>Copulation - drug effects</topic><topic>Copulation - physiology</topic><topic>Dopamine - physiology</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Ejaculation</topic><topic>Ejaculation - drug effects</topic><topic>Ejaculation - physiology</topic><topic>Female</topic><topic>Fluoxetine</topic><topic>Fluoxetine - administration & dosage</topic><topic>Fluoxetine - toxicity</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Serotonin</topic><topic>Serotonin - physiology</topic><topic>Serotonin Uptake Inhibitors - administration & dosage</topic><topic>Serotonin Uptake Inhibitors - toxicity</topic><topic>Sexual behavior</topic><topic>Sexual Behavior, Animal - drug effects</topic><topic>Sexual Behavior, Animal - physiology</topic><topic>Toxicity: urogenital system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wieseler Frank, Julie L</creatorcontrib><creatorcontrib>Hendricks, Shelton E</creatorcontrib><creatorcontrib>Olson, Christian H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Animal Behavior Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wieseler Frank, Julie L</au><au>Hendricks, Shelton E</au><au>Olson, Christian H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple Ejaculations and Chronic Fluoxetine: Effects on Male Rat Copulatory Behavior</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>66</volume><issue>2</issue><spage>337</spage><epage>342</epage><pages>337-342</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>WIESELER FRANK, J. L., S. E. HENDRICKS AND C. H. OLSON.
Multiple ejaculations and chronic fluoxetine: effects on male rat copulatory behavior. PHARMACOL BIOCHEM BEHAV
66(2) 337–342, 2000.—Male rats were treated with fluoxetine (FLX) or vehicle daily for 14 days and copulatory behavior tested on day 15. Rats were either mated to three ejaculations or to sexual exhaustion. Both standard measures and the mount bout analysis were used to evaluate the effects of the chronic FLX on male rat copulatory behavior. Only 56.25% of the animals treated with FLX achieved three ejaculations. FLX inhibited the consumatory aspect of male sexual behavior, especially the ability to achieve three ejaculations, but there was no effect on the propensity of the male to pursue the female. These differences were observed for the first three ejaculations. Analysis of the last three ejaculations in those animals that mated to exhaustion did not reveal an effect of FLX. The behavioral pattern of FLX-treated animals during the first three ejaculations resembled that observed during the last three ejaculatory series in the vehicle-treated animals that mated to exhaustion. The results are discussed in terms of the serotonergic effects on male rat sexual behavior.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10880687</pmid><doi>10.1016/S0091-3057(00)00191-X</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Appetitive Behavior - drug effects Appetitive Behavior - physiology Biological and medical sciences Consummatory Behavior - drug effects Consummatory Behavior - physiology Copulation - drug effects Copulation - physiology Dopamine - physiology Drug toxicity and drugs side effects treatment Ejaculation Ejaculation - drug effects Ejaculation - physiology Female Fluoxetine Fluoxetine - administration & dosage Fluoxetine - toxicity Male Medical sciences Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Serotonin Serotonin - physiology Serotonin Uptake Inhibitors - administration & dosage Serotonin Uptake Inhibitors - toxicity Sexual behavior Sexual Behavior, Animal - drug effects Sexual Behavior, Animal - physiology Toxicity: urogenital system |
| title | Multiple Ejaculations and Chronic Fluoxetine: Effects on Male Rat Copulatory Behavior |
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